{"id":"https://openalex.org/W2037536659","doi":"https://doi.org/10.1074/jbc.m211249200","title":"Solution 1H NMR Investigation of the Active Site Molecular and Electronic Structures of Substrate-bound, Cyanide-inhibited HmuO, a Bacterial Heme Oxygenase fromCorynebacterium diphtheriae","display_name":"Solution 1H NMR Investigation of the Active Site Molecular and Electronic Structures of Substrate-bound, Cyanide-inhibited HmuO, a Bacterial Heme Oxygenase fromCorynebacterium diphtheriae","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2037536659","doi":"https://doi.org/10.1074/jbc.m211249200","mag":"2037536659","pmid":"https://pubmed.ncbi.nlm.nih.gov/12480929"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m211249200","doi":"https://doi.org/10.1074/jbc.m211249200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m211249200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m211249200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yiming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiming Li","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, California 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032525793","display_name":"Ray T. Syvitski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray T. Syvitski","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023780336","display_name":"Grace C. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace C. Chu","raw_affiliation_strings":["Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021983843","display_name":"Masao Ikeda\u2010Saito","orcid":"https://orcid.org/0000-0002-0562-3616","observed_orcids":["https://orcid.org/0000-0002-0562-3616"]},"institutions":[{"id":"https://openalex.org/I4405286139","display_name":"Institute of Multidisciplinary Research for Advanced Materials, Tohoku University","ror":"https://ror.org/017qp9z94","country_code":"JP","type":"facility","lineage":["https://openalex.org/I201537933","https://openalex.org/I4405286139"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masao Ikeda-Saito","raw_affiliation_strings":["Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970","Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahura, Aoba-ku, Sendai 980-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahura, Aoba-ku, Sendai 980-8577, Japan","institution_ids":["https://openalex.org/I4405286139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113449542","display_name":"Gerd N. La Mar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerd N. La Mar","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113449542"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7728,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83010997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"278","issue":"9","first_page":"6651","last_page":"6663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/corynebacterium-diphtheriae","display_name":"Corynebacterium diphtheriae","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyanide-inhibition","display_name":"cyanide inhibition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ordered-water-molecules","display_name":"ordered water molecules","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.7766026258468628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7344996333122253},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.7238345742225647},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.6296616196632385},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5819770097732544},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5588515996932983},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5205205678939819},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5063420534133911},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4809417128562927},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.47759413719177246},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.43165531754493713},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.20244824886322021},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10800275206565857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10056668519973755},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07674837112426758},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07627519965171814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0721951425075531},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003353","descriptor_name":"Corynebacterium diphtheriae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003353","descriptor_name":"Corynebacterium diphtheriae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m211249200","doi":"https://doi.org/10.1074/jbc.m211249200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m211249200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12480929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12480929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m211249200","doi":"https://doi.org/10.1074/jbc.m211249200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m211249200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6221311519","display_name":null,"funder_award_id":"GM 62380","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8163071938","display_name":"CATALYTIC MECHANISMS OF HEME ENZYMES","funder_award_id":"R01GM057272","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W91760036","https://openalex.org/W562908385","https://openalex.org/W622652757","https://openalex.org/W625272620","https://openalex.org/W1483386503","https://openalex.org/W1491642680","https://openalex.org/W1572334445","https://openalex.org/W1586487499","https://openalex.org/W1871163165","https://openalex.org/W1964747891","https://openalex.org/W1966431834","https://openalex.org/W1969737762","https://openalex.org/W1970675158","https://openalex.org/W1972459558","https://openalex.org/W1977916819","https://openalex.org/W1982963160","https://openalex.org/W1987469536","https://openalex.org/W1990748283","https://openalex.org/W1990918364","https://openalex.org/W1992456814","https://openalex.org/W1997624484","https://openalex.org/W2010262048","https://openalex.org/W2017380395","https://openalex.org/W2021706740","https://openalex.org/W2022693510","https://openalex.org/W2030777478","https://openalex.org/W2030901966","https://openalex.org/W2031732123","https://openalex.org/W2034329041","https://openalex.org/W2038554626","https://openalex.org/W2045950270","https://openalex.org/W2048413031","https://openalex.org/W2054501531","https://openalex.org/W2062972508","https://openalex.org/W2065112654","https://openalex.org/W2067127132","https://openalex.org/W2072256632","https://openalex.org/W2074770586","https://openalex.org/W2097600127","https://openalex.org/W2103314026","https://openalex.org/W2109261480","https://openalex.org/W2144674829","https://openalex.org/W2145530136","https://openalex.org/W2145550766","https://openalex.org/W2949250147","https://openalex.org/W2951380517","https://openalex.org/W4213234002"],"related_works":["https://openalex.org/W2083864143","https://openalex.org/W2027588444","https://openalex.org/W1990748283","https://openalex.org/W2092724028","https://openalex.org/W2168427863","https://openalex.org/W2101897226","https://openalex.org/W2331879621","https://openalex.org/W1987413081","https://openalex.org/W1990918364","https://openalex.org/W1987469536"],"abstract_inverted_index":{"The":[0,85,160,176,202],"molecular":[1],"structure":[2,171],"and":[3,51,54,67,99,118,149,217],"dynamic":[4,203],"properties":[5],"of":[6,11,69,73,92,95,102,172,205],"the":[7,18,31,46,57,65,70,74,81,103,167,173,185,190,199,221],"active":[8],"site":[9],"environment":[10],"HmuO,":[12],"a":[13,37],"heme":[14],"oxygenase":[15],"(HO)":[16],"from":[17],"pathogenic":[19],"bacterium":[20],"Corynebacterium":[21],"diphtheriae,":[22],"have":[23],"been":[24],"investigated":[25],"by":[26],"(1)H":[27],"NMR":[28,161],"spectroscopy":[29],"using":[30],"human":[32],"HO":[33,83,227],"(hHO)":[34],"complex":[35],"as":[36],"homology":[38],"model.":[39],"It":[40],"is":[41,122,127,211],"demonstrated":[42],"that":[43,60,88,112,126,130,197],"not":[44],"only":[45],"spatial":[47],"contacts":[48],"among":[49],"residues":[50,53],"between":[52],"heme,":[55],"but":[56],"magnetic":[58],"axes":[59],"can":[61],"be":[62],"related":[63],"to":[64,129,183],"direction":[66],"magnitude":[68],"steric":[71,93,100],"tilt":[72,101],"FeCN":[75],"unit":[76],"are":[77,106,163,181],"strongly":[78],"conserved":[79],"in":[80,124,133,195,209,215,225],"two":[82],"complexes.":[84],"results":[86,162],"indicate":[87],"very":[89,115,168],"similar":[90],"contributions":[91],"blockage":[94],"several":[96],"meso":[97],"positions":[98],"attacking":[104],"ligand":[105],"operative.":[107],"A":[108],"distal":[109,186],"H-bond":[110,177,207],"network":[111,208],"involves":[113],"numerous":[114],"strong":[116],"H-bonds":[117],"immobilized":[119],"water":[120,179,187],"molecules":[121,180],"identified":[123,132],"HmuO":[125,210],"analogous":[128],"previously":[131],"hHO":[134,216],"(Li,":[135],"Y.,":[136],"Syvitski,":[137],"R.":[138],"T.,":[139],"Auclair,":[140],"K.,":[141],"Wilks,":[142],"A.,":[143],"Ortiz":[144],"de":[145],"Montellano,":[146],"P.":[147],"R.,":[148],"La":[150],"Mar,":[151],"G.":[152],"N.":[153],"(2002)":[154],"J.":[155],"Biol.":[156],"Chem.":[157],"277,":[158],"33018-33031).":[159],"completely":[164],"consistent":[165],"with":[166,229],"recent":[169],"crystal":[170],"HmuO.substrate":[174],"complex.":[175],"network/ordered":[178],"proposed":[182],"orient":[184],"molecule":[188],"near":[189],"catalytically":[191],"key":[192],"Asp(136)":[193],"(Asp(140)":[194],"hHO)":[196],"stabilizes":[198],"hydroperoxy":[200],"intermediate.":[201],"stability":[204],"this":[206],"significantly":[212],"greater":[213],"than":[214],"may":[218],"account":[219],"for":[220],"slower":[222],"catalytic":[223],"rate":[224],"bacterial":[226],"compared":[228],"mammalian":[230],"HO.":[231]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}