{"id":"https://openalex.org/W2037418873","doi":"https://doi.org/10.1113/jphysiol.1985.sp015707","title":"Modulation of slow response excitability by calcium in rabbit atrial trabeculae.","display_name":"Modulation of slow response excitability by calcium in rabbit atrial trabeculae.","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2037418873","doi":"https://doi.org/10.1113/jphysiol.1985.sp015707","mag":"2037418873","pmid":"https://pubmed.ncbi.nlm.nih.gov/4020700","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1192926"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1985.sp015707","doi":"https://doi.org/10.1113/jphysiol.1985.sp015707","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1985.sp015707","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1192926","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088989450","display_name":"Samuel Cukierman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Cukierman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088989450"],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.13769614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"363","issue":"1","first_page":"237","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slow-response","display_name":"slow response","score":0.906000018119812},{"id":"https://openalex.org/keywords/atrial-trabeculae","display_name":"atrial trabeculae","score":0.6940000057220459},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.49300000071525574},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.5429999828338623},{"id":"https://openalex.org/keywords/d600","display_name":"D600","score":0.7599999904632568},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/subthreshold-responses","display_name":"subthreshold responses","score":0.6349999904632568},{"id":"https://openalex.org/keywords/left-atrium","display_name":"left atrium","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7170552015304565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.693457305431366},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6653012037277222},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6269663572311401},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.556052565574646},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5441840291023254},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5266786813735962},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.5189287662506104},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5054216384887695},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.48038655519485474},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.4736396372318268},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.45404353737831116},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42052987217903137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4041789770126343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3849085569381714},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.24030959606170654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13026952743530273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1289241909980774},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12247389554977417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11185282468795776},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005711","descriptor_name":"Gallopamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013324","descriptor_name":"Strontium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1985.sp015707","doi":"https://doi.org/10.1113/jphysiol.1985.sp015707","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1985.sp015707","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1192926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1192926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:4020700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4020700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1192926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1192926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1970311357","https://openalex.org/W1972769530","https://openalex.org/W1974153471","https://openalex.org/W1978819017","https://openalex.org/W1982311430","https://openalex.org/W1985940938","https://openalex.org/W1987894568","https://openalex.org/W1990660486","https://openalex.org/W1998025248","https://openalex.org/W2002523635","https://openalex.org/W2003552383","https://openalex.org/W2004079359","https://openalex.org/W2004582891","https://openalex.org/W2013271540","https://openalex.org/W2024391578","https://openalex.org/W2029333932","https://openalex.org/W2039411714","https://openalex.org/W2042152248","https://openalex.org/W2047255322","https://openalex.org/W2053838901","https://openalex.org/W2066520340","https://openalex.org/W2070955119","https://openalex.org/W2090486528","https://openalex.org/W2095691742","https://openalex.org/W2101966660","https://openalex.org/W2111822563","https://openalex.org/W2120003464","https://openalex.org/W2129595564","https://openalex.org/W2138151365","https://openalex.org/W2166286431","https://openalex.org/W2166932524","https://openalex.org/W2246105844","https://openalex.org/W2331595741","https://openalex.org/W2403995716","https://openalex.org/W2444000850"],"related_works":["https://openalex.org/W2412024772","https://openalex.org/W2071155301","https://openalex.org/W2066520340","https://openalex.org/W7100168774","https://openalex.org/W1975888341","https://openalex.org/W7099151826","https://openalex.org/W2183546829","https://openalex.org/W136321148","https://openalex.org/W2145134591","https://openalex.org/W2414578004"],"abstract_inverted_index":{"Slow":[0],"responses":[1,116],"were":[2,24],"induced":[3],"in":[4,10,78,181,199,207,222,253,285],"rabbit":[5],"isolated":[6],"left":[7],"atrial":[8],"trabeculae":[9],"a":[11,59,76,259],"modified":[12],"Tyrode":[13],"solution":[14],"containing":[15],"15":[16],"mM-KCl":[17],"and":[18,28,135,266],"1":[19],"mM-BaCl2.":[20],"Conventional":[21],"electrophysiological":[22],"techniques":[23],"employed":[25],"for":[26,58,282,311],"stimulating":[27],"recording":[29],"membrane":[30],"potentials.":[31],"Under":[32],"these":[33],"conditions,":[34],"the":[35,38,43,48,51,64,67,88,122,132,150,153,167,178,195,209,216,229,232,238,241,248,277,283,293,301,304],"excitability":[36,65,112,145,214,288,302],"of":[37,47,62,66,91,108,124,141,152,186,197,211,218,231,240,258,303],"slow":[39,68,84,110,115,133,143,154,212,233,242,268,286,297,305],"response":[40,69,85,111,134,144,155,213,243,261,269,279,287,298],"depends":[41],"on":[42,215],"past":[44],"excitatory":[45],"history":[46],"preparation.":[49],"As":[50],"stimulation":[52],"frequency":[53,217],"increases":[54],"(range:":[55],"0.08-1":[56],"Hz)":[57],"conditioning":[60,89],"period":[61,90],"stimulation,":[63],"increases.":[70],"This":[71],"can":[72,117],"be":[73,119,205],"demonstrated":[74],"by":[75,158,165,273],"decrease":[77],"stimulus":[79],"requirement":[80],"necessary":[81],"to":[82,103,126,149,169,173,204],"maintain":[83],"excitation":[86,230,239,270],"following":[87],"stimulation.":[92,219],"It":[93],"is":[94,101,146,271,280,290],"shown":[95],"that":[96,106,193,264,292],"when":[97],"extracellular":[98,223],"Ca2+":[99,163,198,224,294],"concentration":[100,164],"reduced":[102],"0.5":[104],"mM,":[105],"phenomenon":[107],"frequency-dependent":[109,137,142],"disappears":[113],"but":[114],"still":[118],"elicited.":[120],"Also,":[121],"addition":[123,185],"D-600":[125],"2.7":[127],"mM-Ca2+":[128],"solutions":[129,171,201],"depresses":[130],"both":[131],"its":[136],"excitability.":[138],"The":[139,184,220,256],"absence":[140],"not":[147,176],"related":[148],"depression":[151],"upstroke":[156],"caused":[157],"low-Ca2+":[159,182,200],"solutions.":[160,183],"Increasing":[161],"intracellular":[162],"exposing":[166],"preparation":[168,249],"low-Na+":[170],"or":[172,190],"ouabain":[174],"did":[175],"revert":[177],"observed":[179],"effects":[180],"substances":[187],"(5":[188],"mM-caffeine":[189],"0.35":[191],"microM-adrenaline)":[192],"potentiate":[194],"influx":[196],"was":[202,244],"found":[203],"effective":[206],"restoring":[208],"dependence":[210],"increase":[221],"above":[225],"4":[226],"mM":[227],"depressed":[228],"response.":[234,306],"Above":[235],"5.4":[236],"mM-Ca2+,":[237],"completely":[245],"inhibited":[246],"while":[247],"displayed":[250],"continuous":[251],"oscillations":[252],"transmembrane":[254],"potential.":[255],"presence":[257],"subthreshold":[260],"(subliminal":[262],"response)":[263],"precedes":[265],"triggers":[267],"accompanied":[272],"tension":[274],"development.":[275],"Since":[276],"subliminal":[278],"responsible":[281],"changes":[284],"it":[289],"proposed":[291],"inflow":[295],"during":[296],"electrogenesis":[299],"modulates":[300],"Two":[307],"possible":[308],"physiological":[309],"implications":[310],"this":[312],"finding":[313],"are":[314],"discussed.":[315]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
