{"id":"https://openalex.org/W2037413610","doi":"https://doi.org/10.1074/jbc.m111.281394","title":"EPI64 Protein Functions as a Physiological GTPase-activating Protein for Rab27 Protein and Regulates Amylase Release in Rat Parotid Acinar Cells","display_name":"EPI64 Protein Functions as a Physiological GTPase-activating Protein for Rab27 Protein and Regulates Amylase Release in Rat Parotid Acinar Cells","publication_year":2011,"publication_date":"2011-08-06","ids":{"openalex":"https://openalex.org/W2037413610","doi":"https://doi.org/10.1074/jbc.m111.281394","mag":"2037413610","pmid":"https://pubmed.ncbi.nlm.nih.gov/21832089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3190813"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.281394","doi":"https://doi.org/10.1074/jbc.m111.281394","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.281394","pdf_url":"http://www.jbc.org/article/S0021925820739323/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820739323/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015359287","display_name":"Akane Imai","orcid":"https://orcid.org/0000-0001-9780-4870","observed_orcids":["https://orcid.org/0000-0001-9780-4870"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akane Imai","raw_affiliation_strings":["Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan. imaiak@ngt.ndu.ac.jp","Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan. imaiak@ngt.ndu.ac.jp","institution_ids":["https://openalex.org/I35552710"]},{"raw_affiliation_string":"Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063108303","display_name":"Sumio Yoshie","orcid":"https://orcid.org/0000-0002-5767-2508","observed_orcids":["https://orcid.org/0000-0002-5767-2508"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumio Yoshie","raw_affiliation_strings":["Department of Histology, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081539048","display_name":"Koutaro Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koutaro Ishibashi","raw_affiliation_strings":["Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044788345","display_name":"Maiko Haga\u2010Tsujimura","orcid":"https://orcid.org/0000-0001-8985-3015","observed_orcids":["https://orcid.org/0000-0001-8985-3015"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maiko Haga-Tsujimura","raw_affiliation_strings":["Department of Histology, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028111961","display_name":"Tomoko Nashida","orcid":"https://orcid.org/0000-0002-5629-762X","observed_orcids":["https://orcid.org/0000-0002-5629-762X"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Nashida","raw_affiliation_strings":["Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022013480","display_name":"Hiromi Shimomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Shimomura","raw_affiliation_strings":["Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006129467","display_name":"Mitsunori Fukuda","orcid":"https://orcid.org/0000-0002-8620-5853","observed_orcids":["https://orcid.org/0000-0002-8620-5853"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsunori Fukuda","raw_affiliation_strings":["Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006129467","https://openalex.org/A5015359287"],"corresponding_institution_ids":["https://openalex.org/I201537933","https://openalex.org/I35552710"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.831,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.66137156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"286","issue":"39","first_page":"33854","last_page":"33862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab27","display_name":"Rab27","score":0.968999981880188},{"id":"https://openalex.org/keywords/rab27a","display_name":"Rab27a","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tbc-domain","display_name":"TBC domain","score":0.8939999938011169},{"id":"https://openalex.org/keywords/parotid-acinar-cells","display_name":"parotid acinar cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/amylase-secretion","display_name":"amylase secretion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/isoproterenol-stimulation","display_name":"isoproterenol stimulation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/small-gtpase-regulation","display_name":"small GTPase regulation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/apical-membrane","display_name":"apical membrane","score":0.777999997138977},{"id":"https://openalex.org/keywords/exocrine-secretion","display_name":"exocrine secretion","score":0.49000000953674316},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.767005443572998},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.7129570245742798},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.5805190205574036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48575761914253235},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.47261834144592285},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.38233286142349243},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.336290180683136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2471712827682495}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.281394","doi":"https://doi.org/10.1074/jbc.m111.281394","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.281394","pdf_url":"http://www.jbc.org/article/S0021925820739323/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2451838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3190813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21832089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21832089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3190813","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3190813/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.281394","doi":"https://doi.org/10.1074/jbc.m111.281394","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.281394","pdf_url":"http://www.jbc.org/article/S0021925820739323/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080081606","display_name":"Investigation on the molecular mechanism of aquaporin 5 distribution in salivary glands of Sjogren's syndrome model mice","funder_award_id":"23592781","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037413610.pdf","grobid_xml":"https://content.openalex.org/works/W2037413610.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1595083713","https://openalex.org/W1937789354","https://openalex.org/W1967585280","https://openalex.org/W1973200579","https://openalex.org/W1973577506","https://openalex.org/W1975230069","https://openalex.org/W1976543990","https://openalex.org/W1979751563","https://openalex.org/W1984121795","https://openalex.org/W1984978236","https://openalex.org/W1988178943","https://openalex.org/W1994668150","https://openalex.org/W1995281032","https://openalex.org/W1998981152","https://openalex.org/W2000686839","https://openalex.org/W2004003705","https://openalex.org/W2005114787","https://openalex.org/W2007171704","https://openalex.org/W2008370397","https://openalex.org/W2011045082","https://openalex.org/W2016852261","https://openalex.org/W2027199606","https://openalex.org/W2032508216","https://openalex.org/W2036915037","https://openalex.org/W2039369869","https://openalex.org/W2043019778","https://openalex.org/W2049616876","https://openalex.org/W2054176091","https://openalex.org/W2059346525","https://openalex.org/W2064880862","https://openalex.org/W2066444607","https://openalex.org/W2067247420","https://openalex.org/W2070101581","https://openalex.org/W2071651950","https://openalex.org/W2077215675","https://openalex.org/W2080020860","https://openalex.org/W2089778398","https://openalex.org/W2089913733","https://openalex.org/W2092956427","https://openalex.org/W2117138208","https://openalex.org/W2120272671","https://openalex.org/W2120920292","https://openalex.org/W2126660909","https://openalex.org/W2131097779","https://openalex.org/W2134492570","https://openalex.org/W2143111492","https://openalex.org/W2146072506","https://openalex.org/W2157049512","https://openalex.org/W2164319030","https://openalex.org/W2166595775","https://openalex.org/W2190894417","https://openalex.org/W2208451345","https://openalex.org/W2265269529"],"related_works":["https://openalex.org/W2129191639","https://openalex.org/W2043899069","https://openalex.org/W2043019778","https://openalex.org/W2134492570","https://openalex.org/W2092956427","https://openalex.org/W2016571973","https://openalex.org/W2546723844","https://openalex.org/W2160534582","https://openalex.org/W2091769576","https://openalex.org/W2164319030"],"abstract_inverted_index":{"Rab27,":[0],"a":[1,22,69,172,220],"small":[2],"GTPase,":[3],"is":[4,238],"generally":[5],"recognized":[6],"as":[7,219],"an":[8,145],"important":[9],"regulator":[10],"of":[11,25,39,42,67,109,138,151,158,181,203,210,227],"secretion":[12],"that":[13,65,129,144,178,192,216,223,235],"interacts":[14],"with":[15,194],"Rab27-specific":[16],"effectors":[17],"to":[18,231],"regulate":[19],"events":[20],"in":[21,59,73,95,113,156,162,171,229],"wide":[23],"variety":[24],"cells,":[26],"including":[27],"endocrine":[28],"and":[29,48,82,125,167,184,191,207,234],"exocrine":[30],"cells.":[31,61,122,141],"However,":[32],"the":[33,36,92,107,134,148,154,159,179,201,208],"mechanisms":[34],"governing":[35],"spatio-temporal":[37],"regulation":[38],"GTPase":[40,225],"activity":[41,226,237],"Rab27":[43,55,112,228],"are":[44],"not":[45],"firmly":[46],"established,":[47],"no":[49],"GTPase-activating":[50],"protein":[51,186,206],"(GAP)":[52],"specific":[53],"for":[54,240],"has":[56,98],"been":[57,100],"identified":[58],"secretory":[60,96],"We":[62,142,175],"previously":[63],"showed":[64],"expression":[66],"EPI64,":[68],"Tre-2/Bub2/Cdc16":[70],"(TBC)-domain-containing":[71],"protein,":[72],"melanocytes":[74],"inactivates":[75],"endogenous":[76,160],"Rab27A":[77],"on":[78,111,133],"melanosomes":[79],"(Itoh,":[80],"T.,":[81],"Fukuda,":[83],"M.":[84],"(2006)":[85],"J.":[86],"Biol.":[87],"Chem.":[88],"281,":[89],"31823-31831),":[90],"but":[91],"EPI64":[93,110,130,152,182,185,204,217],"role":[94],"cells":[97,166],"never":[99],"investigated.":[101],"In":[102],"this":[103,236],"study,":[104],"we":[105],"investigated":[106],"effect":[108],"isoproterenol":[114],"(IPR)-stimulated":[115],"amylase":[116,169,211,242],"release":[117,170],"from":[118],"rat":[119],"parotid":[120,139,164],"acinar":[121,140,165],"Subcellular":[123],"fractionation":[124],"immunohistochemical":[126],"analyses":[127],"indicated":[128,215],"was":[131],"enriched":[132],"apical":[135],"plasma":[136],"membrane":[137],"found":[143,177],"antibody":[146],"against":[147],"TBC/Rab-GAP":[149],"domain":[150],"inhibited":[153],"reduction":[155],"levels":[157,180],"GTP-Rab27":[161],"streptolysin-O-permeabilized":[163],"suppressed":[168,200],"dose-dependent":[173],"manner.":[174],"also":[176],"mRNA":[183],"increased":[187],"after":[188],"IPR":[189,232],"stimulation,":[190,233],"treatment":[193],"actinomycin":[195],"D":[196],"or":[197],"antisense-EPI64":[198],"oligonucleotides":[199],"increase":[202],"mRNA/EPI64":[205],"amount":[209],"released.":[212],"Our":[213],"findings":[214],"acted":[218],"physiological":[221],"Rab27-GAP":[222],"enhanced":[224],"response":[230],"required":[239],"IPR-induced":[241],"release.":[243]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
