{"id":"https://openalex.org/W203737162","doi":null,"title":"Effects of oxygen on the newborn.","display_name":"Effects of oxygen on the newborn.","publication_year":1985,"publication_date":"1985-04-01","ids":{"openalex":"https://openalex.org/W203737162","mag":"203737162","pmid":"https://pubmed.ncbi.nlm.nih.gov/3884388"},"language":"en","primary_location":{"id":"pmid:3884388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112308970","display_name":"L. Frank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Frank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112308970"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8523,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.94532964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"44","issue":"7","first_page":"2328","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/free-radical-theory","display_name":"free radical theory","score":0.7200000286102295},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.75},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pharmacological-prophylaxis","display_name":"pharmacological prophylaxis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neonatal-lung","display_name":"neonatal lung","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.8915503025054932},{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.7899616956710815},{"id":"https://openalex.org/C2777590204","wikidata":"https://www.wikidata.org/wiki/Q125223","display_name":"Oxygen toxicity","level":3,"score":0.7706359624862671},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7068492770195007},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6921961307525635},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6524083614349365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4961126744747162},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4630143344402313},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4261270761489868},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4159150719642639},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3792230188846588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3606117367744446},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.330314040184021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2943837642669678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14156129956245422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10552191734313965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3884388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},{"id":"mag:203737162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2056678512","https://openalex.org/W2414827707","https://openalex.org/W2394789833","https://openalex.org/W1973593141","https://openalex.org/W2086383563","https://openalex.org/W2489621361","https://openalex.org/W2007213736","https://openalex.org/W2116200135","https://openalex.org/W2069177787","https://openalex.org/W2025058949"],"abstract_inverted_index":{"The":[0,130],"free":[1],"radical":[2],"theory":[3],"of":[4,11,14,31,34,38,56,67,72,79,97,132,149,165,193],"O2":[5,52,73,102,125],"toxicity":[6],"provides":[7,27],"a":[8,19],"testable":[9],"explanation":[10],"the":[12,32,39,64,76,80,88,133,160,166,172,184,190],"mechanism":[13],"O2's":[15],"toxic":[16],"effects":[17,66],"on":[18],"biochemical":[20],"and":[21,41,118],"cellular":[22],"level.":[23],"In":[24],"addition,":[25],"it":[26],"for":[28,140],"an":[29,42],"understanding":[30],"array":[33],"normal":[35,95],"antioxidant":[36,99,151,162],"defenses":[37],"cell":[40],"insight":[43],"to":[44,47,63,69,92,147,158,180],"rational":[45],"approaches":[46],"pharmacologic":[48,155],"prophylaxis":[49],"against":[50,143],"clinical":[51,191],"toxicity.":[53],"Neonatal":[54],"animals":[55,78],"many":[57],"species":[58],"are":[59,75],"much":[60],"more":[61],"resistant":[62],"lethal":[65],"exposure":[68,145],"high":[70],"concentrations":[71],"than":[74],"adult":[77],"species;":[81],"this":[82],"increased":[83],"tolerance":[84],"is":[85],"associated":[86,188],"with":[87,123,189],"newborn":[89],"lungs'":[90],"ability":[91],"increase":[93],"its":[94,150],"complement":[96],"protective":[98],"enzymes":[100],"during":[101],"exposure.":[103],"Premature":[104],"infants":[105],"who":[106],"require":[107],"vigorous":[108],"hyperoxic":[109,144],"respiratory":[110],"support":[111],"early":[112],"in":[113,171],"life":[114],"frequently":[115],"develop":[116],"acute":[117],"chronic":[119],"lung":[120,131,167,186],"changes":[121],"compatible":[122],"pulmonary":[124],"toxicity,":[126],"so-called":[127],"bronchopulmonary":[128],"dysplasia.":[129],"prematurely":[134],"born":[135],"may":[136,168],"be":[137],"quite":[138],"ill-adapted":[139],"protecting":[141],"itself":[142],"owing":[146],"immaturity":[148],"defensive":[152,163],"systems.":[153],"Clinical":[154],"stratagems":[156],"designed":[157],"augment":[159],"intracellular":[161],"capacity":[164],"become":[169],"available":[170],"near":[173],"future,":[174],"which":[175],"would":[176],"provide":[177],"some":[178],"means":[179],"prevent":[181],"or":[182],"ameliorate":[183],"serious":[185],"damage":[187],"use":[192],"life-giving":[194],"O2.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}