{"id":"https://openalex.org/W2037300482","doi":"https://doi.org/10.1007/bf01968098","title":"Direct inhibition of cyclooxygenase pathway in platelets by tixocortol 21-pivalate: comparison with related structures, steroidal and non steroidal anti-inflammatory drugs","display_name":"Direct inhibition of cyclooxygenase pathway in platelets by tixocortol 21-pivalate: comparison with related structures, steroidal and non steroidal anti-inflammatory drugs","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2037300482","doi":"https://doi.org/10.1007/bf01968098","mag":"2037300482","pmid":"https://pubmed.ncbi.nlm.nih.gov/3136624"},"language":"en","primary_location":{"id":"doi:10.1007/bf01968098","doi":"https://doi.org/10.1007/bf01968098","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01968098","pdf_url":null,"source":{"id":"https://openalex.org/S55943811","display_name":"Inflammation Research","issn_l":"1023-3830","issn":["1023-3830","1420-908X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agents and Actions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"V. Lelievre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Lelievre","raw_affiliation_strings":["Jouveinal Laboratoires, Fresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jouveinal Laboratoires, Fresnes, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Martin","raw_affiliation_strings":["Jouveinal Laboratoires, F-94263, Fresnes, France","Jouveinal Laboratoires, Fresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jouveinal Laboratoires, F-94263, Fresnes, France","institution_ids":[]},{"raw_affiliation_string":"Jouveinal Laboratoires, Fresnes, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035188850","display_name":"Jacques Bure","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Bure","raw_affiliation_strings":["Jouveinal Laboratoires, F-94263, Fresnes, France","Jouveinal Laboratoires, Fresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jouveinal Laboratoires, F-94263, Fresnes, France","institution_ids":[]},{"raw_affiliation_string":"Jouveinal Laboratoires, Fresnes, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045325079","display_name":"Jean\u2010Louis Junien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Junien","raw_affiliation_strings":["Jouveinal Laboratoires, F-94263, Fresnes, France","Jouveinal Laboratoires, Fresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jouveinal Laboratoires, F-94263, Fresnes, France","institution_ids":[]},{"raw_affiliation_string":"Jouveinal Laboratoires, Fresnes, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.8309,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70261879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1-2","first_page":"179","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9649999737739563},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.8389999866485596},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8100000023841858},{"id":"https://openalex.org/keywords/anti-inflammatory-steroids","display_name":"anti-inflammatory steroids","score":0.7049999833106995},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":1.0},{"id":"https://openalex.org/keywords/12-lipoxygenase","display_name":"12-lipoxygenase","score":0.890999972820282},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8169999718666077},{"id":"https://openalex.org/keywords/s-methylation","display_name":"S-methylation","score":0.628000020980835},{"id":"https://openalex.org/keywords/s-oxidation","display_name":"S-oxidation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8141679763793945},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.771051287651062},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5372229814529419},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4970732033252716},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.4738495945930481},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4619174003601074},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.45685747265815735},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4339088499546051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41026079654693604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2905671000480652},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19981634616851807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14488539099693298},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019377","descriptor_name":"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01968098","doi":"https://doi.org/10.1007/bf01968098","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01968098","pdf_url":null,"source":{"id":"https://openalex.org/S55943811","display_name":"Inflammation Research","issn_l":"1023-3830","issn":["1023-3830","1420-908X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agents and Actions","raw_type":"journal-article"},{"id":"pmid:3136624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3136624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agents and actions","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1499516889","https://openalex.org/W1585808802","https://openalex.org/W1972070463","https://openalex.org/W1972728887","https://openalex.org/W1974488004","https://openalex.org/W1980563273","https://openalex.org/W1982751982","https://openalex.org/W2004855226","https://openalex.org/W2008574207","https://openalex.org/W2018068140","https://openalex.org/W2018666601","https://openalex.org/W2026144498","https://openalex.org/W2026747332","https://openalex.org/W2038933163","https://openalex.org/W2054813534","https://openalex.org/W2058994566","https://openalex.org/W2067893981","https://openalex.org/W2069267604","https://openalex.org/W2075751764","https://openalex.org/W2088465805","https://openalex.org/W2091678501","https://openalex.org/W2098211926","https://openalex.org/W2119076610","https://openalex.org/W2130700424","https://openalex.org/W2298403442","https://openalex.org/W2413648130","https://openalex.org/W2417225132","https://openalex.org/W2470086205","https://openalex.org/W2506121317","https://openalex.org/W4240857734"],"related_works":["https://openalex.org/W1972728887","https://openalex.org/W2019589125","https://openalex.org/W1997805804","https://openalex.org/W2109870057","https://openalex.org/W2952783681","https://openalex.org/W2064762853","https://openalex.org/W2047120625","https://openalex.org/W1994402788","https://openalex.org/W2030764366","https://openalex.org/W1976365391"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}