{"id":"https://openalex.org/W2037211353","doi":"https://doi.org/10.1016/s0895-7061(99)00249-6","title":"Localization and function of angiotensin AT1 receptors","display_name":"Localization and function of angiotensin AT1 receptors","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2037211353","doi":"https://doi.org/10.1016/s0895-7061(99)00249-6","mag":"2037211353","pmid":"https://pubmed.ncbi.nlm.nih.gov/10678286"},"language":"en","primary_location":{"id":"doi:10.1016/s0895-7061(99)00249-6","doi":"https://doi.org/10.1016/s0895-7061(99)00249-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0895-7061(99)00249-6","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018735152","display_name":"Andrew Mark Allen","orcid":"https://orcid.org/0000-0002-2183-5360","observed_orcids":["https://orcid.org/0000-0002-2183-5360"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"A ALLEN","raw_affiliation_strings":["Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia","Howard Florey Institute of Experimental Physiology & Medicine, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"raw_affiliation_string":"Howard Florey Institute of Experimental Physiology & Medicine, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161508755","display_name":"J Zhuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Zhuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161692187","display_name":"F A Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F A Mendelsohn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018735152"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":2.2096,"has_fulltext":true,"cited_by_count":288,"citation_normalized_percentile":{"value":0.89252336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"S31","last_page":"S38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/receptor-distribution","display_name":"receptor distribution","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cardiac-conduction-system","display_name":"cardiac conduction system","score":0.7310000061988831},{"id":"https://openalex.org/keywords/vagal-ganglia","display_name":"vagal ganglia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/circumventricular-organs","display_name":"circumventricular organs","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.6269999742507935},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.5070000290870667},{"id":"https://openalex.org/keywords/fluid-reabsorption","display_name":"fluid reabsorption","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6510000228881836},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.8117347955703735},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7660708427429199},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6985573768615723},{"id":"https://openalex.org/C2777619780","wikidata":"https://www.wikidata.org/wiki/Q205925","display_name":"Circumventricular organs","level":3,"score":0.6973897814750671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6776946187019348},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6669263243675232},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.6029758453369141},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5331881046295166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4845951795578003},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.42239296436309814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3429911136627197},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.21036970615386963}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011945","descriptor_name":"Receptors, Angiotensin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0895-7061(99)00249-6","doi":"https://doi.org/10.1016/s0895-7061(99)00249-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0895-7061(99)00249-6","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:10678286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10678286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1263659","https://openalex.org/W46078365","https://openalex.org/W90696980","https://openalex.org/W1527240164","https://openalex.org/W1591510379","https://openalex.org/W1761989175","https://openalex.org/W1821554906","https://openalex.org/W1840798497","https://openalex.org/W1844072728","https://openalex.org/W1955102539","https://openalex.org/W1965570459","https://openalex.org/W1967561584","https://openalex.org/W1968874083","https://openalex.org/W1971275688","https://openalex.org/W1975304753","https://openalex.org/W1976758127","https://openalex.org/W1976765944","https://openalex.org/W1981045101","https://openalex.org/W1989204474","https://openalex.org/W1990257506","https://openalex.org/W1993197471","https://openalex.org/W1997084645","https://openalex.org/W1997932090","https://openalex.org/W1998976251","https://openalex.org/W1999422984","https://openalex.org/W2000938726","https://openalex.org/W2008087295","https://openalex.org/W2010031713","https://openalex.org/W2011129367","https://openalex.org/W2011965024","https://openalex.org/W2012444504","https://openalex.org/W2013205933","https://openalex.org/W2020103404","https://openalex.org/W2023849708","https://openalex.org/W2026971452","https://openalex.org/W2031988153","https://openalex.org/W2033459863","https://openalex.org/W2041994812","https://openalex.org/W2042525524","https://openalex.org/W2044518616","https://openalex.org/W2048770882","https://openalex.org/W2051332153","https://openalex.org/W2058713776","https://openalex.org/W2059129712","https://openalex.org/W2061498814","https://openalex.org/W2061898251","https://openalex.org/W2063349406","https://openalex.org/W2071482392","https://openalex.org/W2082110280","https://openalex.org/W2082542825","https://openalex.org/W2083077388","https://openalex.org/W2084339368","https://openalex.org/W2086389958","https://openalex.org/W2089025918","https://openalex.org/W2089547639","https://openalex.org/W2091631803","https://openalex.org/W2096682768","https://openalex.org/W2098568217","https://openalex.org/W2102186417","https://openalex.org/W2131033837","https://openalex.org/W2138443098","https://openalex.org/W2141986088","https://openalex.org/W2145879452","https://openalex.org/W2148601507","https://openalex.org/W2151592841","https://openalex.org/W2168964746","https://openalex.org/W2180153357","https://openalex.org/W2287336533","https://openalex.org/W2313654315","https://openalex.org/W2412866325","https://openalex.org/W2413432722","https://openalex.org/W2438057456","https://openalex.org/W3154155560","https://openalex.org/W4317524290"],"related_works":["https://openalex.org/W1629865234","https://openalex.org/W1582423989","https://openalex.org/W2000579941","https://openalex.org/W2044518616","https://openalex.org/W2026185220","https://openalex.org/W2403799431","https://openalex.org/W2996186063","https://openalex.org/W2131438048","https://openalex.org/W2127571106","https://openalex.org/W2067946831"],"abstract_inverted_index":{"The":[0,85,193,208,226],"distributions":[1],"of":[2,18,41,66,87,115,139,153,196,200,228,253,265],"angiotensin":[3,189,197],"AT1":[4,28,74,121,154,172,254],"and":[5,48,52,56,59,98,123,163,224,242,255],"AT2":[6,209,256],"receptors":[7,29,75,111,122,155],"have":[8,68],"been":[9,69],"mapped":[10],"by":[11],"in":[12,31,77,80,118,125,157,176,198,216,231,245],"vitro":[13],"autoradiography":[14],"throughout":[15],"most":[16],"tissues":[17,218],"many":[19,63,177,199,259],"mammals,":[20],"including":[21,219],"humans.":[22],"In":[23,71,147,166],"addition":[24,119],"to":[25,34,103,120,205,239,243],"confirming":[26],"that":[27],"occur":[30,76,156,175],"sites":[32,65,203],"known":[33],"be":[35,104,134,206],"targets":[36],"for":[37,112,136,186],"the":[38,45,72,92,96,99,137,148,150,160,167,180,220,251],"physiologic":[39,194,263],"actions":[40],"angiotensin,":[42],"such":[43],"as":[44,190],"adrenal":[46,221],"cortex":[47],"medulla,":[49],"renal":[50,81,143],"glomeruli":[51],"proximal":[53],"tubules,":[54],"vascular":[55],"cardiac":[57],"muscle":[58],"brain":[60,202],"circumventricular":[61],"organs,":[62],"new":[64],"action":[67],"demonstrated.":[70],"kidney,":[73],"high":[78,171],"density":[79],"medullary":[82,107,144],"interstitial":[83,93,108],"cells.":[84],"function":[86],"these":[88,201],"cells,":[89],"which":[90],"span":[91],"space":[94],"between":[95],"tubules":[97],"vasa":[100],"rectae,":[101],"remains":[102,204],"determined.":[105,207],"Renal":[106],"cells":[109],"possess":[110],"a":[113,184,191,213],"number":[114],"vasoactive":[116],"hormones":[117],"this,":[124],"concert":[126],"with":[127,159],"their":[128],"anatomic":[129],"location,":[130],"suggests":[131],"they":[132],"may":[133],"important":[135],"regulation":[138],"fluid":[140],"reabsorption":[141],"or":[142],"blood":[145],"flow.":[146],"heart,":[149,223],"highest":[151],"densities":[152,174],"association":[158],"conduction":[161],"system":[162],"vagal":[164],"ganglia.":[165],"central":[168],"nervous":[169],"system,":[170],"receptor":[173,210,230],"regions":[178],"behind":[179],"blood-brain":[181],"barrier,":[182],"supporting":[183],"role":[185,195,227],"neurally":[187],"derived":[188],"neuromodulator.":[192],"also":[211],"has":[212],"characteristic":[214],"distribution":[215,252],"several":[217],"gland,":[222],"brain.":[225],"this":[229],"physiology":[232],"is":[233],"being":[234],"elucidated,":[235],"but":[236],"it":[237],"appears":[238],"inhibit":[240],"proliferation":[241],"participate":[244],"development.":[246],"Thus,":[247],"receptor-binding":[248],"studies,":[249],"localizing":[250],"receptors,":[257],"provide":[258],"insights":[260],"into":[261],"novel":[262],"roles":[264],"angiotensin.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
