{"id":"https://openalex.org/W2037101357","doi":"https://doi.org/10.1371/journal.pone.0111025","title":"Endothelium Trans Differentiated from Wharton's Jelly Mesenchymal Cells Promote Tissue Regeneration: Potential Role of Soluble Pro-Angiogenic Factors","display_name":"Endothelium Trans Differentiated from Wharton's Jelly Mesenchymal Cells Promote Tissue Regeneration: Potential Role of Soluble Pro-Angiogenic Factors","publication_year":2014,"publication_date":"2014-11-20","ids":{"openalex":"https://openalex.org/W2037101357","doi":"https://doi.org/10.1371/journal.pone.0111025","mag":"2037101357","pmid":"https://pubmed.ncbi.nlm.nih.gov/25412260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239028"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0111025","doi":"https://doi.org/10.1371/journal.pone.0111025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0111025","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0111025&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0111025&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039111815","display_name":"Valeria Aguilera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Valeria Aguilera","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023624490","display_name":"Luis Brice\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Luis Brice\u00f1o","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101429844","display_name":"H\u00e9ctor Contreras","orcid":"https://orcid.org/0000-0002-1818-9433","observed_orcids":["https://orcid.org/0000-0002-1818-9433"]},"institutions":[{"id":"https://openalex.org/I38685851","display_name":"Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n","ror":"https://ror.org/03y6k2j68","country_code":"CL","type":"education","lineage":["https://openalex.org/I38685851"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Hector Contreras","raw_affiliation_strings":["Faculty of Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I38685851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048911724","display_name":"Liliana Lamperti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Liliana Lamperti","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737642","display_name":"Esperanza Sep\u00falveda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Esperanza Sep\u00falveda","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057072176","display_name":"Francisca D\u00edaz-P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Francisca D\u00edaz-Perez","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078562643","display_name":"Marcelo Le\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Marcelo Le\u00f3n","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034585672","display_name":"Carlos Veas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carlos Veas","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058371190","display_name":"Rafael Maura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Rafael Maura","raw_affiliation_strings":["Department of Physiopathology, Faculty of Biological Sciences, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiopathology, Faculty of Biological Sciences, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034924392","display_name":"Jorge Roberto Toledo","orcid":"https://orcid.org/0000-0002-9879-7710","observed_orcids":["https://orcid.org/0000-0002-9879-7710"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jorge Roberto Toledo","raw_affiliation_strings":["Department of Physiopathology, Faculty of Biological Sciences, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiopathology, Faculty of Biological Sciences, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103431675","display_name":"Paulina Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]},{"id":"https://openalex.org/I3124150290","display_name":"Universidad San Sebasti\u00e1n","ror":"https://ror.org/04jrwm652","country_code":"CL","type":"education","lineage":["https://openalex.org/I3124150290"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Paulina Fern\u00e1ndez","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile; Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile","Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile; Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465","https://openalex.org/I3124150290"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]},{"raw_affiliation_string":"Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I3124150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041212822","display_name":"Ambart E. Covarrubias","orcid":"https://orcid.org/0000-0001-6460-9980","observed_orcids":["https://orcid.org/0000-0001-6460-9980"]},"institutions":[{"id":"https://openalex.org/I3124150290","display_name":"Universidad San Sebasti\u00e1n","ror":"https://ror.org/04jrwm652","country_code":"CL","type":"education","lineage":["https://openalex.org/I3124150290"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ambart Covarrubias","raw_affiliation_strings":["Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad Ciencias de la Salud, Escuela de Tecnolog\u00eda M\u00e9dica, Universidad San Sebasti\u00e1n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I3124150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051750761","display_name":"Felipe Andr\u00e9s Zu\u00f1iga","orcid":"https://orcid.org/0000-0003-0286-565X","observed_orcids":["https://orcid.org/0000-0003-0286-565X"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Felipe Andr\u00e9s Zu\u00f1iga","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008191558","display_name":"Claudia Radojkovic","orcid":"https://orcid.org/0000-0002-1383-8422","observed_orcids":["https://orcid.org/0000-0002-1383-8422"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Claudia Radojkovic","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045840372","display_name":"Carlos Escudero","orcid":"https://orcid.org/0000-0001-7688-4621","observed_orcids":["https://orcid.org/0000-0001-7688-4621"]},"institutions":[{"id":"https://openalex.org/I221450849","display_name":"University of B\u00edo-B\u00edo","ror":"https://ror.org/04dndfk38","country_code":"CL","type":"education","lineage":["https://openalex.org/I221450849"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carlos Escudero","raw_affiliation_strings":["Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","institution_ids":["https://openalex.org/I221450849"]},{"raw_affiliation_string":"Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","institution_ids":["https://openalex.org/I221450849"]},{"raw_affiliation_string":"Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","institution_ids":["https://openalex.org/I221450849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062757789","display_name":"Claudio R. Aguayo","orcid":"https://orcid.org/0000-0003-4565-9602","observed_orcids":["https://orcid.org/0000-0003-4565-9602"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]},{"id":"https://openalex.org/I221450849","display_name":"University of B\u00edo-B\u00edo","ror":"https://ror.org/04dndfk38","country_code":"CL","type":"education","lineage":["https://openalex.org/I221450849"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Claudio Aguayo","raw_affiliation_strings":["Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","institution_ids":["https://openalex.org/I172787465","https://openalex.org/I221450849"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]},{"raw_affiliation_string":"Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n, Chile","institution_ids":["https://openalex.org/I221450849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062757789"],"corresponding_institution_ids":["https://openalex.org/I172787465","https://openalex.org/I221450849"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.0057,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91455614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"11","first_page":"e111025","last_page":"e111025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wharton-s-jelly","display_name":"Wharton's jelly","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6259999871253967},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9700000286102295},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7609999775886536},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.5450000166893005},{"id":"https://openalex.org/keywords/skin-damage","display_name":"skin damage","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C119577978","wikidata":"https://www.wikidata.org/wiki/Q913900","display_name":"Wharton's jelly","level":3,"score":0.9611345529556274},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8976230621337891},{"id":"https://openalex.org/C116716535","wikidata":"https://www.wikidata.org/wiki/Q5009851","display_name":"CD90","level":4,"score":0.6872730255126953},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5824798941612244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5641998052597046},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.506442666053772},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4781559407711029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4443521499633789},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4359048008918762},{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.4192018508911133},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36795535683631897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.355654239654541},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.3359912037849426},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1496340036392212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09103506803512573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0111025","doi":"https://doi.org/10.1371/journal.pone.0111025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0111025","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0111025&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4239028","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25412260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25412260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.5431","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.5431","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/41/f5/pone.0111025.PMC4239028.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3230696","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3230696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7a590b3e6b064202808dd53bc2394cfb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7a590b3e6b064202808dd53bc2394cfb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 11, p e111025 (2014)","raw_type":"article"},{"id":"pmh:oai:localhost:10533/138586","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/138586","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0111025","doi":"https://doi.org/10.1371/journal.pone.0111025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0111025","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0111025&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309575","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48"},{"id":"https://openalex.org/F4320311278","display_name":"Corporaci\u00f3n de Fomento de la Producci\u00f3n","ror":"https://ror.org/00as45r68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037101357.pdf","grobid_xml":"https://content.openalex.org/works/W2037101357.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W345833723","https://openalex.org/W1578357314","https://openalex.org/W1964654600","https://openalex.org/W1969644104","https://openalex.org/W1982108697","https://openalex.org/W1982426523","https://openalex.org/W1989126478","https://openalex.org/W1990419136","https://openalex.org/W1996789930","https://openalex.org/W2000960050","https://openalex.org/W2003325734","https://openalex.org/W2004886833","https://openalex.org/W2005943573","https://openalex.org/W2006052369","https://openalex.org/W2008737522","https://openalex.org/W2015623756","https://openalex.org/W2019586013","https://openalex.org/W2025371271","https://openalex.org/W2027540026","https://openalex.org/W2028953197","https://openalex.org/W2029497643","https://openalex.org/W2033288777","https://openalex.org/W2035176325","https://openalex.org/W2035342267","https://openalex.org/W2035582618","https://openalex.org/W2036966078","https://openalex.org/W2054095354","https://openalex.org/W2054166149","https://openalex.org/W2061954405","https://openalex.org/W2063697232","https://openalex.org/W2064523371","https://openalex.org/W2067909031","https://openalex.org/W2073027756","https://openalex.org/W2076229475","https://openalex.org/W2084136724","https://openalex.org/W2092054789","https://openalex.org/W2092885226","https://openalex.org/W2093006514","https://openalex.org/W2095132685","https://openalex.org/W2104225093","https://openalex.org/W2104421682","https://openalex.org/W2106193879","https://openalex.org/W2109738220","https://openalex.org/W2115499481","https://openalex.org/W2127644172","https://openalex.org/W2127734192","https://openalex.org/W2132028114","https://openalex.org/W2135067231","https://openalex.org/W2139779507","https://openalex.org/W2156364581","https://openalex.org/W2157520030","https://openalex.org/W2158177754","https://openalex.org/W2159999899","https://openalex.org/W2163993250","https://openalex.org/W2171630160","https://openalex.org/W4249994679","https://openalex.org/W4297935661"],"related_works":["https://openalex.org/W2033288777","https://openalex.org/W1990419136","https://openalex.org/W2073027756","https://openalex.org/W2598283765","https://openalex.org/W2083948684","https://openalex.org/W1979228443","https://openalex.org/W2550817521","https://openalex.org/W2055600964","https://openalex.org/W2127240946","https://openalex.org/W2583278299"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mesenchymal":[1,75],"stem":[2,30,61,76,233],"cells":[3,31,43,57,62,77,149,234],"have":[4],"a":[5,25,45,191],"high":[6,151,169],"capacity":[7],"for":[8,48,94],"trans-differentiation":[9,91,118],"toward":[10],"many":[11],"adult":[12],"cell":[13],"types,":[14],"including":[15],"endothelial":[16,56,111,125,145,162,172,247],"cells.":[17,146,248],"Feto-placental":[18],"tissue,":[19],"such":[20],"as":[21],"Wharton's":[22,65,82,237],"jelly":[23,66,83,238],"is":[24],"potential":[26,46],"source":[27,40],"of":[28,41,55,124,153,161,171,179,188,194,262],"mesenchymal":[29,60,106,232],"with":[32,44,86,202,205,210],"low":[33,159],"immunogenic":[34],"capacity;":[35],"make":[36],"them":[37],"an":[38],"excellent":[39],"progenitor":[42],"use":[47],"tissue":[49,70,255],"repair.":[50],"We":[51],"evaluated":[52],"whether":[53],"administration":[54],"derived":[58],"from":[59,64,80,224,236],"isolated":[63,79,235],"(hWMSCs)":[67],"can":[68,137,184,239],"accelerate":[69],"repair":[71,256],"in":[72,190,218,242,257],"vivo.":[73],"METHODS:":[74],"were":[78,215],"human":[81],"by":[84,121],"digestion":[85],"collagenase":[87],"type":[88],"I.":[89],"Endothelial":[90,117],"was":[92,103,119],"induced":[93],"14":[95,175],"(hWMSC-End14d)":[96],"and":[97,110,127,144,156,176,181,244,254],"30":[98,177],"(hWMSC-End30d)":[99],"days.":[100],"Cell":[101],"phenotyping":[102],"performed":[104],"using":[105],"(CD90,":[107],"CD73,":[108,154],"CD105)":[109],"(Tie-2,":[112],"KDR,":[113],"eNOS,":[114],"ICAM-1)":[115],"markers.":[116],"demonstrated":[120],"the":[122,260],"expression":[123,152,160],"markers":[126,163,173],"their":[128],"ability":[129],"to":[130,165],"synthesize":[131,185],"nitric":[132],"oxide":[133],"(NO).":[134],"RESULTS:":[135],"hWMSCs":[136],"be":[138,240],"differentiated":[139],"into":[140,246],"adipocytes,":[141],"osteocytes,":[142],"chondrocytes":[143],"Moreover,":[147],"these":[148],"show":[150],"CD90":[155],"CD105":[157],"but":[158],"prior":[164],"differentiation.":[166],"hWMSCs-End":[167],"express":[168],"levels":[170],"at":[174],"days":[178],"culture,":[180],"also":[182,216],"they":[183],"NO.":[186],"Injection":[187],"hWMSC-End30d":[189,225],"mouse":[192],"model":[193],"skin":[195],"injury":[196],"significantly":[197],"accelerated":[198],"wound":[199],"healing":[200],"compared":[201],"animals":[203,219],"injected":[204,209],"undifferentiated":[206],"hWMSC":[207],"or":[208],"vehicle":[211],"alone.":[212],"These":[213,228],"effects":[214],"observed":[217],"that":[220,231],"received":[221],"conditioned":[222],"media":[223],"cultures.":[226],"CONCLUSION:":[227],"results":[229],"demonstrate":[230],"cultured":[241],"vitro":[243],"trans-differentiated":[245],"Differentiated":[249],"hWMSC-End":[250],"may":[251],"promote":[252],"neovascularization":[253],"vivo":[258],"through":[259],"secretion":[261],"soluble":[263],"pro-angiogenic":[264],"factors.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
