{"id":"https://openalex.org/W2037017107","doi":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","title":"Rat embryos cultured under copper\u2010deficient conditions develop abnormally and are characterized by an impaired oxidant defense system","display_name":"Rat embryos cultured under copper\u2010deficient conditions develop abnormally and are characterized by an impaired oxidant defense system","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2037017107","doi":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","mag":"2037017107","pmid":"https://pubmed.ncbi.nlm.nih.gov/9664639"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","doi":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","pdf_url":null,"source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113539050","display_name":"Susan Nicole Hawk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan N. Hawk","raw_affiliation_strings":["Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111850491","display_name":"Janet Y. Uriu\u2010Hare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Y. Uriu\u2010Hare","raw_affiliation_strings":["Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110002800","display_name":"George P. Daston","orcid":"https://orcid.org/0009-0008-5627-2327","observed_orcids":["https://orcid.org/0009-0008-5627-2327"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George P. Daston","raw_affiliation_strings":["The Procter &amp; Gamble Company, Cincinanti, Ohio 45202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Procter &amp; Gamble Company, Cincinanti, Ohio 45202","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108637107","display_name":"Margaret A. Jankowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Jankowski","raw_affiliation_strings":["Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067204793","display_name":"Catherine L. Kwik-Uribe","orcid":"https://orcid.org/0000-0001-5684-039X","observed_orcids":["https://orcid.org/0000-0001-5684-039X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Kwik\u2010Uribe","raw_affiliation_strings":["Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015043500","display_name":"Robert B. Rucker","orcid":"https://orcid.org/0000-0002-7804-0278","observed_orcids":["https://orcid.org/0000-0002-7804-0278"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Rucker","raw_affiliation_strings":["Department of Internal Medicine, University of California, Davis, Davis, California 95616\u20108669","Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043985150","display_name":"Carl L. Keen","orcid":"https://orcid.org/0000-0001-6602-4417","observed_orcids":["https://orcid.org/0000-0001-6602-4417"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl L. Keen","raw_affiliation_strings":["Department of Internal Medicine, University of California, Davis, Davis, California 95616\u20108669","Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, Davis, California 95616\u20108669","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043985150"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":1.4077,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80803571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"57","issue":"6","first_page":"310","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-deficiency","display_name":"copper deficiency","score":0.9940000176429749},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7990000247955322},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cardiac-defects","display_name":"cardiac defects","score":0.5230000019073486},{"id":"https://openalex.org/keywords/hindbrain-malformation","display_name":"hindbrain malformation","score":0.625},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/dietary-copper","display_name":"dietary copper","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.8064086437225342},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6643123626708984},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6057400703430176},{"id":"https://openalex.org/C2777106986","wikidata":"https://www.wikidata.org/wiki/Q1495005","display_name":"Copper deficiency","level":3,"score":0.5571178197860718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46198588609695435},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.46071726083755493},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45713815093040466},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.449300616979599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4340461492538452},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.42761728167533875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3704965114593506},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3356538414955139},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.3331484794616699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2792847454547882},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19505584239959717},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.19430479407310486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14241674542427063},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.13209229707717896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07467472553253174},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","doi":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.0.co;2-#","pdf_url":null,"source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.3.co;2-k","doi":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.3.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9926(199806)57:6<310::aid-tera4>3.3.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},{"id":"pmid:9664639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9664639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1184801511","display_name":"Pre &Postdoctoral Training in Nutrition","funder_award_id":"T32DK007355","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8765784686","display_name":"COPPER NUTRITION AND DEVELOPMENT","funder_award_id":"R01HD026777","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G935309894","display_name":"CLINICAL NUTRITION RESEARCH UNIT","funder_award_id":"P30DK035747","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W90432907","https://openalex.org/W121642688","https://openalex.org/W188283553","https://openalex.org/W962061814","https://openalex.org/W1484563081","https://openalex.org/W1499452235","https://openalex.org/W1554089382","https://openalex.org/W1556607526","https://openalex.org/W1561528529","https://openalex.org/W1592080522","https://openalex.org/W1788982145","https://openalex.org/W1847518188","https://openalex.org/W1855112763","https://openalex.org/W1873078527","https://openalex.org/W1892584697","https://openalex.org/W1926541489","https://openalex.org/W1977477377","https://openalex.org/W1985975597","https://openalex.org/W1987438923","https://openalex.org/W2001486727","https://openalex.org/W2001552497","https://openalex.org/W2005924555","https://openalex.org/W2012453142","https://openalex.org/W2017215416","https://openalex.org/W2027651810","https://openalex.org/W2029932272","https://openalex.org/W2032946737","https://openalex.org/W2032982569","https://openalex.org/W2036226628","https://openalex.org/W2044556913","https://openalex.org/W2045495757","https://openalex.org/W2054153004","https://openalex.org/W2061288729","https://openalex.org/W2067588722","https://openalex.org/W2086319830","https://openalex.org/W2091327880","https://openalex.org/W2091343707","https://openalex.org/W2093319519","https://openalex.org/W2095584746","https://openalex.org/W2112260651","https://openalex.org/W2114989981","https://openalex.org/W2127435036","https://openalex.org/W2129905922","https://openalex.org/W2138936818","https://openalex.org/W2151624907","https://openalex.org/W2169647820","https://openalex.org/W2169864122","https://openalex.org/W2318340336","https://openalex.org/W2390235908","https://openalex.org/W4297573539","https://openalex.org/W4385272083"],"related_works":["https://openalex.org/W2142993751","https://openalex.org/W2048226531","https://openalex.org/W2088950940","https://openalex.org/W2037946071","https://openalex.org/W2390235908","https://openalex.org/W2735786132","https://openalex.org/W2315305441","https://openalex.org/W2145265813","https://openalex.org/W1873078527","https://openalex.org/W2163991416"],"abstract_inverted_index":{"Rat":[0],"embryos":[1,41,72,79,98,148,191],"(gestation":[2],"days":[3],"9.0":[4],"and":[5,68,77],"10.0)":[6],"obtained":[7],"from":[8,50],"dams":[9,52],"that":[10,94,107,174],"were":[11,25,46,111],"fed":[12],"a":[13,90,128],"Cu-adequate":[14,31],"(8":[15],"micrograms":[16,22],"Cu/g)":[17],"or":[18,34,162],"Cu-deficient":[19,35,51,58,75,78,97,101,151,155,190],"(<":[20],"0.5":[21],"Cu/g":[23],"diet":[24],"cultured":[26,42,56,73,80,99,141,149],"for":[27],"48":[28],"hr":[29],"in":[30,43,57,74,81,100,113,139,147,150],"(16.2":[32],"microM)":[33,37],"(1.0":[36],"rat":[38],"serum.":[39,102,152],"Control":[40,71],"control":[44,82,201],"serum":[45,76,83,156],"morphologically":[47],"normal.":[48],"Embryos":[49],"developed":[53],"abnormally":[54],"when":[55],"serum;":[59],"the":[60,96,105,108,140,154,172,182,189],"abnormalities":[61,110],"included":[62],"distended":[63],"hindbrains,":[64],"blisters,":[65],"blood":[66],"pooling,":[67],"cardiac":[69],"defects.":[70],"also":[84,192],"showed":[85],"abnormal":[86],"development,":[87],"but":[88],"to":[89,115,122,133,181,200,208],"lesser":[91],"degree":[92],"than":[93],"of":[95],"To":[103],"test":[104],"idea":[106,173],"above":[109],"due":[112],"part":[114],"free":[116],"radical":[117],"induced":[118],"damage":[119],"occurring":[120],"secondary":[121],"an":[123,175],"impaired":[124,176],"oxidant":[125,177],"defense":[126,178],"system,":[127],"chemiluminescence":[129],"assay":[130],"was":[131,145,157,167],"used":[132],"detect":[134],"superoxide":[135],"dismutase":[136],"(SOD)":[137],"activity":[138,144,198],"embryos.":[142],"SOD":[143],"lowest":[146],"When":[153],"supplemented":[158],"with":[159,185],"antioxidants":[160],"(CuZnSOD":[161],"glutathione":[163],"peroxidase),":[164],"its":[165],"teratogenicity":[166],"reduced.":[168],"These":[169],"data":[170],"support":[171],"system":[179],"contributes":[180],"dysmorphology":[183],"associated":[184],"Cu":[186,209],"deficiency.":[187],"However,":[188],"had":[193],"low":[194],"cytochrome":[195],"c":[196],"oxidase":[197],"compared":[199],"embryos--thus,":[202],"multiple":[203],"factors":[204],"are":[205],"likely":[206],"contributing":[207],"deficiency-induced":[210],"abnormalities.":[211]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}