{"id":"https://openalex.org/W2036635716","doi":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","title":"Modeling Cortical Cataractogenesis: IX Activity of Vitamin E and Esters in Preventing Cataracts and \u03b3\u2010Crystallin Leakage from Lenses in Diabetic Rats","display_name":"Modeling Cortical Cataractogenesis: IX Activity of Vitamin E and Esters in Preventing Cataracts and \u03b3\u2010Crystallin Leakage from Lenses in Diabetic Rats","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2036635716","doi":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","mag":"2036635716","pmid":"https://pubmed.ncbi.nlm.nih.gov/2629605"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1989.tb14935.x","doi":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110381737","display_name":"John R. Trevithick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. R. TREVITHICK","raw_affiliation_strings":["Department of Biochemistry, University of Western Ontario, London, Canada","*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088444481","display_name":"H.A. Linklater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"H. A. LINKLATER","raw_affiliation_strings":["*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018487950","display_name":"Kenneth Patrick Mitton","orcid":"https://orcid.org/0000-0002-4751-7440","observed_orcids":["https://orcid.org/0000-0002-4751-7440"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. P. MITTON","raw_affiliation_strings":["*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113772352","display_name":"Thomasz Dzialoszynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T. DZIALOSZYNSKI","raw_affiliation_strings":["*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113478976","display_name":"S. E. Sanford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. E. SANFORD","raw_affiliation_strings":["a Veterinary Services Laboratory Ontario Ministry of Agriculture and Food Huron Park, Ontario, Canada, N0M 1Y0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Veterinary Services Laboratory Ontario Ministry of Agriculture and Food Huron Park, Ontario, Canada, N0M 1Y0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.4995,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.61105815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"570","issue":"1","first_page":"358","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cataract-formation","display_name":"cataract formation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tocopherols","display_name":"tocopherols","score":0.7990000247955322},{"id":"https://openalex.org/keywords/vitamin-e-succinate","display_name":"vitamin E succinate","score":0.7609999775886536},{"id":"https://openalex.org/keywords/alpha-tocopheryl-acetate","display_name":"alpha-tocopherol acetate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gamma-crystallin","display_name":"gamma-crystallin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/diabetic-cataract","display_name":"diabetic cataract","score":0.7739999890327454},{"id":"https://openalex.org/keywords/lens-weight","display_name":"lens weight","score":0.48399999737739563},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.5809999704360962},{"id":"https://openalex.org/keywords/body-condition","display_name":"body condition","score":0.4869999885559082},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C521751864","wikidata":"https://www.wikidata.org/wiki/Q1729207","display_name":"Christian ministry","level":2,"score":0.7230339646339417},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.46852487325668335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4049842357635498},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3451305031776428},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.20358318090438843},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.09679228067398071},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024502","descriptor_name":"alpha-Tocopherol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D024505","descriptor_name":"Tocopherols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1989.tb14935.x","doi":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1989.tb14935.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:2629605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2629605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W232403896","https://openalex.org/W1506909279","https://openalex.org/W1837235869","https://openalex.org/W1965256102","https://openalex.org/W1971174807","https://openalex.org/W1971391254","https://openalex.org/W1978398238","https://openalex.org/W1982070786","https://openalex.org/W1983303750","https://openalex.org/W1987702784","https://openalex.org/W1988540419","https://openalex.org/W2000799431","https://openalex.org/W2003325615","https://openalex.org/W2007163905","https://openalex.org/W2011492430","https://openalex.org/W2013411223","https://openalex.org/W2013887768","https://openalex.org/W2016439933","https://openalex.org/W2019625816","https://openalex.org/W2025080271","https://openalex.org/W2029239541","https://openalex.org/W2029421339","https://openalex.org/W2031326213","https://openalex.org/W2040022608","https://openalex.org/W2044013342","https://openalex.org/W2045678878","https://openalex.org/W2046100838","https://openalex.org/W2046306858","https://openalex.org/W2059489515","https://openalex.org/W2070773991","https://openalex.org/W2072776757","https://openalex.org/W2073533590","https://openalex.org/W2075552513","https://openalex.org/W2076947927","https://openalex.org/W2087184652","https://openalex.org/W2087433889","https://openalex.org/W2089190984","https://openalex.org/W2093359174","https://openalex.org/W2132607488","https://openalex.org/W2227709048","https://openalex.org/W2333527673","https://openalex.org/W2342939245","https://openalex.org/W2397667877","https://openalex.org/W2411394781","https://openalex.org/W2420306198","https://openalex.org/W2423417130","https://openalex.org/W2460627117","https://openalex.org/W2588651157","https://openalex.org/W4205203157","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2463967346","https://openalex.org/W2063262433","https://openalex.org/W1992027491","https://openalex.org/W2423417130","https://openalex.org/W831192027","https://openalex.org/W2045678878","https://openalex.org/W2046306858","https://openalex.org/W2155343712","https://openalex.org/W4248761211","https://openalex.org/W2054342726"],"abstract_inverted_index":{"Normal":[0],"and":[1,42,54,61,88,110,131,141,163],"streptozotocin":[2],"diabetic":[3],"female":[4],"Wistar":[5],"rats":[6,31],"were":[7,32,57],"given":[8],"vitamin":[9,139,142,147,191],"E":[10,140,143,148,192],"in":[11,59,71,85,95,104,106,120,133,154,166,193],"the":[12,15,25,30,92,96,108,151,160,175,179,194,199,202],"diet":[13,152,195],"as":[14],"tocopherol,":[16],"acetate,":[17,149],"or":[18,37,183],"succinate":[19],"form":[20],"(2,850":[21],"IU/kg":[22],"food).":[23],"At":[24,44],"end":[26],"of":[27,51,125,129,138,156,201],"6":[28],"weeks,":[29],"examined":[33],"for":[34,49,76,174],"weight":[35,200],"gain":[36],"loss,":[38],"general":[39,121,180],"body":[40,122,126,167,181],"condition,":[41,123,182],"cataracts.":[43],"sacrifice,":[45],"blood":[46],"was":[47,69,83,170],"collected":[48],"measurement":[50],"serum":[52],"glucose,":[53],"gamma-crystallin":[55,82,105,157],"levels":[56],"measured":[58],"aqueous":[60,87,109],"vitreous":[62,89,97,111,161],"humors":[63,162],"using":[64],"a":[65,101,117],"radioimmunoassay.":[66],"One":[67],"lens":[68,134,176],"homogenized":[70],"8":[72],"M":[73],"guanidinium":[74],"chloride":[75],"ATP":[77,135,177],"analysis.":[78],"In":[79],"normal":[80],"rats,":[81],"detected":[84],"both":[86,107],"humors,":[90],"with":[91],"higher":[93],"concentration":[94],"humor.":[98],"Diabetes":[99,113],"caused":[100],"sixfold":[102],"increase":[103,165],"humors.":[112],"also":[114],"led":[115],"to":[116,150,197],"significant":[118],"worsening":[119],"loss":[124],"weight,":[127],"formation":[128],"cataracts,":[130],"decrease":[132],"levels.":[136],"Addition":[137],"succinate,":[144],"but":[145],"not":[146],"resulted":[153],"reduction":[155],"leakage":[158],"into":[159],"an":[164],"weight.":[168],"There":[169],"no":[171],"improvement":[172],"noted":[173],"levels,":[178],"visual":[184],"cataract":[185],"score.":[186],"Neither":[187],"streptozotocin-induced":[188],"diabetes":[189],"nor":[190],"appeared":[196],"affect":[198],"lenses.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
