{"id":"https://openalex.org/W2036627211","doi":"https://doi.org/10.1136/archdischild-2014-307384.707","title":"PO-0030 Case Report: Heparin-induced Thrombocytopenia (hit) In Two Children After Fontan Procedure","display_name":"PO-0030 Case Report: Heparin-induced Thrombocytopenia (hit) In Two Children After Fontan Procedure","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2036627211","doi":"https://doi.org/10.1136/archdischild-2014-307384.707","mag":"2036627211"},"language":"en","primary_location":{"id":"doi:10.1136/archdischild-2014-307384.707","doi":"https://doi.org/10.1136/archdischild-2014-307384.707","is_oa":false,"landing_page_url":"https://doi.org/10.1136/archdischild-2014-307384.707","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology and Cardiac Surgery","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062811950","display_name":"Anna Hofer","orcid":"https://orcid.org/0000-0002-0340-5471","observed_orcids":["https://orcid.org/0000-0002-0340-5471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hofer","raw_affiliation_strings":["Anesthesiology and Intensive Care, Gerneral Hospital Linz, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Intensive Care, Gerneral Hospital Linz, Linz, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011653947","display_name":"Martina Heschl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Heschl","raw_affiliation_strings":["Anesthesiology and Intensive Care, Gerneral Hospital Linz, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Intensive Care, Gerneral Hospital Linz, Linz, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A260.2","last_page":"A260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-induced-thrombocytopenia","display_name":"heparin-induced thrombocytopenia","score":1.0},{"id":"https://openalex.org/keywords/fontan-procedure","display_name":"Fontan procedure","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pediatric-cardiac-surgery","display_name":"pediatric cardiac surgery","score":0.7319999933242798},{"id":"https://openalex.org/keywords/argatroban","display_name":"argatroban","score":0.8569999933242798},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.7720000147819519},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.962759256362915},{"id":"https://openalex.org/C2779612170","wikidata":"https://www.wikidata.org/wiki/Q474880","display_name":"Argatroban","level":4,"score":0.9414807558059692},{"id":"https://openalex.org/C2776472838","wikidata":"https://www.wikidata.org/wiki/Q1598365","display_name":"Heparin-induced thrombocytopenia","level":3,"score":0.7626081705093384},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5879384875297546},{"id":"https://openalex.org/C2776704044","wikidata":"https://www.wikidata.org/wiki/Q2852541","display_name":"Vitamin K antagonist","level":4,"score":0.5507088303565979},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5345124006271362},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5013432502746582},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49794816970825195},{"id":"https://openalex.org/C2777987278","wikidata":"https://www.wikidata.org/wiki/Q4677454","display_name":"Activated clotting time","level":3,"score":0.49063077569007874},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4362153112888336},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.42347386479377747},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3573077619075775},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3264828324317932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3202279210090637},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.13707473874092102},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.08822256326675415},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/archdischild-2014-307384.707","doi":"https://doi.org/10.1136/archdischild-2014-307384.707","is_oa":false,"landing_page_url":"https://doi.org/10.1136/archdischild-2014-307384.707","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology and Cardiac Surgery","raw_type":"proceedings-article"},{"id":"pmh:oai:open-archive.highwire.org:archdischild:99/Suppl_2/A260-b","doi":null,"is_oa":false,"landing_page_url":"http://adc.bmj.com/cgi/content/short/99/Suppl_2/A260-b","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2507803798","https://openalex.org/W264714493","https://openalex.org/W2107695488","https://openalex.org/W2017441930","https://openalex.org/W2162071577","https://openalex.org/W2768399284","https://openalex.org/W2553841153","https://openalex.org/W2560563836","https://openalex.org/W2020340555","https://openalex.org/W4240254760"],"abstract_inverted_index":{"Background":[0],"and":[1,20,39,67,72,83,109,122,155,161],"aims":[2],"Incidence":[3],"of":[4,14,56],"HIT":[5],"in":[6,11,37,41,96],"childhood":[7],"is":[8],"lower":[9,15],"than":[10],"adults":[12],"because":[13,129],"platelet":[16,142],"factor":[17],"4":[18],"levels":[19],"immature":[21],"immune":[22],"system.":[23],"After":[24],"frist":[25],"time":[26],"cardiac":[27],"surgery":[28],"platelet-antibody":[29],"formation":[30],"has":[31],"been":[32],"reported":[33],"to":[34,50,93,112],"be":[35,158,164],"1,7%":[36],"neonates":[38],"6%":[40],"children":[42,57,70],"on":[43],"the":[44,97,118],"5th":[45],"postoperative":[46],"day.":[47],"With":[48],"reexposure":[49],"unfractionated":[51],"heparin":[52],"(UFH)":[53],"even":[54],"52%":[55],"are":[58],"antibody":[59],"positive":[60],"but":[61],"only":[62],"1.3%":[63],"develope":[64],"symptoms.1":[65],"Methods":[66],"results":[68],"Two":[69],"(3":[71],"3.5":[73],"years":[74],"old)":[75],"developed":[76],"thrombopenia":[77],"after":[78],"Fontan":[79,98],"procedure":[80],"(after":[81],"5":[82],"7":[84],"days":[85],"respectively).":[86],"One":[87],"patient":[88,120],"suffered":[89],"from":[90],"cyanosis":[91],"due":[92],"a":[94,113],"thrombus":[95],"tunnel.":[99],"Both":[100],"were":[101],"initially":[102],"treated":[103],"with":[104,105],"continuous":[106],"argatroban":[107,130,150],"infusion":[108],"then":[110],"switched":[111],"vitamin":[114],"k":[115],"antagonist.":[116],"In":[117,139],"second":[119],"aPTT":[121,154],"INR":[123,156],"exceeded":[124],"therapeutic":[125],"values":[126],"during":[127],"transition,":[128],"dosage":[131,162],"was":[132],"not":[133],"reduced":[134],"adequately.":[135],"(Table":[136],"1)":[137],"Conclusion":[138],"both":[140],"patients":[141],"count":[143],"recoverd.":[144],"No":[145],"adverse":[146],"events,":[147],"especially":[148],"no":[149],"induced":[151],"bleeding":[152],"occured.":[153],"should":[157,163],"monitored":[159],"closely":[160],"adapted":[165],"accordingly.":[166],"Mullen":[167],"et":[168,175],"al.":[169,176],"Anesth":[170],"Analg.":[171],"2008;":[172],"107(2):371\u2013378":[173],"Niyati":[174],"Pediatric":[177],"Pharmacol":[178],"Ther.":[179],"2012;":[180],"17(1):12\u201330":[181]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}