{"id":"https://openalex.org/W2036623828","doi":"https://doi.org/10.1053/jlts.2002.33218","title":"Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients","display_name":"Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2036623828","doi":"https://doi.org/10.1053/jlts.2002.33218","mag":"2036623828","pmid":"https://pubmed.ncbi.nlm.nih.gov/12004348"},"language":"en","primary_location":{"id":"doi:10.1053/jlts.2002.33218","doi":"https://doi.org/10.1053/jlts.2002.33218","is_oa":false,"landing_page_url":"https://doi.org/10.1053/jlts.2002.33218","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072231424","display_name":"Claus U. Niemann","orcid":"https://orcid.org/0000-0003-3701-6084","observed_orcids":["https://orcid.org/0000-0003-3701-6084"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claus U. Niemann","raw_affiliation_strings":["Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143-0648, USA. niemannc@anesthesia.ucsf.edu","Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143-0648, USA. niemannc@anesthesia.ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011037187","display_name":"C. Spencer Yost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spencer C. Yost","raw_affiliation_strings":["Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113634517","display_name":"S Mandell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Mandell","raw_affiliation_strings":["Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028506802","display_name":"Thomas K. Henthorn","orcid":"https://orcid.org/0000-0002-8993-3936","observed_orcids":["https://orcid.org/0000-0002-8993-3936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas K. Henthorn","raw_affiliation_strings":["Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072231424"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":0.9522,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77738102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"5","first_page":"476","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.1598999947309494,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splanchnic-circulation","display_name":"splanchnic circulation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/end-stage-liver-disease","display_name":"end-stage liver disease","score":0.8080000281333923},{"id":"https://openalex.org/keywords/orthotopic-liver-transplantation","display_name":"orthotopic liver transplantation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mean-transit-time","display_name":"mean transit time","score":0.9409999847412109},{"id":"https://openalex.org/keywords/systemic-hemodynamics","display_name":"systemic hemodynamics","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hyperdynamic-circulation","display_name":"hyperdynamic circulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.628000020980835},{"id":"https://openalex.org/keywords/blood-volume","display_name":"blood volume","score":0.8899999856948853},{"id":"https://openalex.org/keywords/living-liver-donors","display_name":"living liver donors","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pulse-dye-densitometry","display_name":"pulse dye densitometry","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.9015496969223022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8517752885818481},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.820270299911499},{"id":"https://openalex.org/C2909144591","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic Circulation","level":4,"score":0.6982582807540894},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5713779926300049},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5657071471214294},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.5222331285476685},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.47976526618003845},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.43458783626556396},{"id":"https://openalex.org/C2779065481","wikidata":"https://www.wikidata.org/wiki/Q8578745","display_name":"Hyperdynamic circulation","level":4,"score":0.42736685276031494},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37469595670700073},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3713570237159729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3456052839756012},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2666221857070923},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.2341931164264679}],"mesh":[{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D019520","descriptor_name":"Living Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/jlts.2002.33218","doi":"https://doi.org/10.1053/jlts.2002.33218","is_oa":false,"landing_page_url":"https://doi.org/10.1053/jlts.2002.33218","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:12004348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12004348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W74649421","https://openalex.org/W1490907837","https://openalex.org/W1620590266","https://openalex.org/W1911650660","https://openalex.org/W1931705081","https://openalex.org/W1938650141","https://openalex.org/W1963673927","https://openalex.org/W1964903138","https://openalex.org/W1975748079","https://openalex.org/W1981749711","https://openalex.org/W2018911073","https://openalex.org/W2019379818","https://openalex.org/W2020019965","https://openalex.org/W2038520956","https://openalex.org/W2038933113","https://openalex.org/W2039895770","https://openalex.org/W2044301984","https://openalex.org/W2050375015","https://openalex.org/W2060691151","https://openalex.org/W2076218874","https://openalex.org/W2084290048","https://openalex.org/W2090952130","https://openalex.org/W2105008390","https://openalex.org/W2108579436","https://openalex.org/W2115229983","https://openalex.org/W2119475555","https://openalex.org/W2130191989","https://openalex.org/W2132605764","https://openalex.org/W2172148175","https://openalex.org/W2573641934"],"related_works":["https://openalex.org/W2116788002","https://openalex.org/W6977899794","https://openalex.org/W4255972912","https://openalex.org/W109406982","https://openalex.org/W2995174948","https://openalex.org/W2021223633","https://openalex.org/W2065261247","https://openalex.org/W2017438086","https://openalex.org/W2057294499","https://openalex.org/W2305198005"],"abstract_inverted_index":{"Although":[0],"indocyanine":[1],"green":[2],"(ICG)":[3],"can":[4,234],"be":[5,235],"used":[6,32],"to":[7,33,87,184,214,239],"estimate":[8],"cardiac":[9],"output":[10],"(CO)":[11],"and":[12,25,44,70,109,114,137,164,187,200,222],"blood":[13,119,220],"volume":[14,221],"independently,":[15],"a":[16,115,143,236],"recirculatory":[17,96],"multicompartmental":[18],"ICG":[19,53,210],"model":[20,30,97,211,233],"enables":[21],"description":[22],"of":[23,37,181,217,243,246],"these":[24],"additional":[26],"intravascular":[27,101],"factors.":[28],"This":[29,232],"was":[31,55,130],"describe":[34],"the":[35,58,126,149,185,196,209,241],"effect":[36,242],"end-stage":[38],"liver":[39,51,68,75],"disease":[40],"(ESLD)":[41],"on":[42],"systemic":[43,199],"splanchnic":[45,201,226,247],"hemodynamics":[46,227],"in":[47,61,125,133,142,146,148,160,176,203],"patients":[48,63,134,204],"undergoing":[49,66],"orthotopic":[50,67],"transplantation.":[52],"disposition":[54],"determined":[56],"during":[57],"dissection":[59],"phase":[60],"six":[62,71],"with":[64,135,195,205],"ESLD":[65,136,140],"transplantation":[69],"healthy":[72],"adult":[73],"living":[74],"donors.":[76],"After":[77],"injecting":[78],"ICG,":[79],"plasma":[80],"concentrations":[81],"were":[82],"obtained":[83],"for":[84],"approximately":[85],"10":[86],"12":[88],"minutes":[89,159,175],"by":[90],"noninvasive":[91],"pulse":[92],"dye":[93],"densitometry.":[94],"The":[95],"characterizes":[98],"three":[99],"distinct":[100],"circuits:":[102],"lumped":[103],"parallel":[104],"fast":[105,127],"(presumably":[106],"nonsplanchnic":[107],"circulation)":[108],"slow":[110,165,188],"peripheral":[111,128,166,189],"(splanchnic)":[112],"circuits":[113],"central":[116,150,186],"circuit":[117,129,167],"(central":[118],"volume).":[120],"Mean":[121],"transit":[122],"time":[123],"(MTT)":[124],"not":[131,218],"different":[132,229],"controls.":[138],"However,":[139],"resulted":[141],"significant":[144],"decrease":[145],"MTT":[147],"(0.11":[151],"+/-":[152,157,169,173],"0.028":[153],"[SD]":[154],"v":[155,171],"0.24":[156],"0.094":[158],"controls;":[161,177],"P":[162,178],"<.001)":[163,179],"(0.67":[168],"0.41":[170],"1.37":[172],"0.37":[174],"because":[180],"increased":[182],"flows":[183],"circuits.":[190],"These":[191],"findings":[192],"are":[193],"consistent":[194],"described":[197],"hyperdynamic":[198],"circulations":[202],"ESLD.":[206],"In":[207],"conclusion,":[208],"is":[212],"able":[213],"derive":[215],"estimates":[216],"only":[219],"CO,":[223],"but":[224],"also":[225],"under":[228],"physiological":[230],"conditions.":[231],"useful":[237],"tool":[238],"evaluate":[240],"pharmacological":[244],"manipulation":[245],"hemodynamics.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}