{"id":"https://openalex.org/W2036618291","doi":"https://doi.org/10.1148/76.5.755","title":"Effects of Intensive Radiation on the Human Heart","display_name":"Effects of Intensive Radiation on the Human Heart","publication_year":1961,"publication_date":"1961-05-01","ids":{"openalex":"https://openalex.org/W2036618291","doi":"https://doi.org/10.1148/76.5.755","mag":"2036618291","pmid":"https://pubmed.ncbi.nlm.nih.gov/13779554"},"language":"en","primary_location":{"id":"doi:10.1148/76.5.755","doi":"https://doi.org/10.1148/76.5.755","is_oa":false,"landing_page_url":"https://doi.org/10.1148/76.5.755","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112173866","display_name":"JEROME M. VAETH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome M. Vaeth","raw_affiliation_strings":["University of California Medical Center, San Francisco 22, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Medical Center, San Francisco 22, Calif","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081705544","display_name":"Lawrence Z. Feigenbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Z. Feigenbaum","raw_affiliation_strings":["University of California Medical Center, San Francisco 22, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Medical Center, San Francisco 22, Calif","institution_ids":["https://openalex.org/I4210110664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109306519","display_name":"Malcolm D. Merrill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm D. Merrill","raw_affiliation_strings":["University of California Medical Center, San Francisco 22, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Medical Center, San Francisco 22, Calif","institution_ids":["https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210110664"],"apc_list":null,"apc_paid":null,"fwci":4.5509,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.92809409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"76","issue":"5","first_page":"755","last_page":"762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-effects-on-the-heart","display_name":"radiation effects on the heart","score":0.7519999742507935},{"id":"https://openalex.org/keywords/normal-tissue-reactions","display_name":"normal tissue response","score":0.4869999885559082},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.515999972820282},{"id":"https://openalex.org/keywords/electrocardiographic-changes","display_name":"electrocardiographic changes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8050000071525574},{"id":"https://openalex.org/keywords/myocardial-degeneration","display_name":"myocardial degeneration","score":0.6480000019073486},{"id":"https://openalex.org/keywords/st-t-wave-changes","display_name":"ST-T changes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/radiation-induced-cardiotoxicity","display_name":"radiation-induced cardiotoxicity","score":0.46000000834465027},{"id":"https://openalex.org/keywords/thoracic-radiotherapy","display_name":"thoracic radiotherapy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/breast-cancer-radiotherapy","display_name":"breast cancer radiotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/esophageal-cancer-radiotherapy","display_name":"esophageal cancer radiotherapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/lung-cancer-radiotherapy","display_name":"lung cancer radiotherapy","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.858833909034729},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.7044272422790527},{"id":"https://openalex.org/C193544012","wikidata":"https://www.wikidata.org/wiki/Q321017","display_name":"Roentgen","level":2,"score":0.629847526550293},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5133711099624634},{"id":"https://openalex.org/C2908795178","wikidata":"https://www.wikidata.org/wiki/Q1795115","display_name":"Kymography","level":2,"score":0.47134989500045776},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.4489806592464447},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.43882137537002563},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3053363561630249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2847253680229187},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1148/76.5.755","doi":"https://doi.org/10.1148/76.5.755","is_oa":false,"landing_page_url":"https://doi.org/10.1148/76.5.755","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},{"id":"pmid:13779554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13779554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2090065744","https://openalex.org/W2164180573","https://openalex.org/W2322654123"],"related_works":["https://openalex.org/W2164180573","https://openalex.org/W4236135627","https://openalex.org/W4254130224","https://openalex.org/W2034181568","https://openalex.org/W2025133791","https://openalex.org/W2038798792","https://openalex.org/W2165758907","https://openalex.org/W2414704597","https://openalex.org/W2068930880","https://openalex.org/W4388103860"],"abstract_inverted_index":{"Recent":[0],"awareness":[1],"of":[2,5,18,31,50,73,77,89,103,125,132,157,175,196,215,239,248,279,290,311,316,324,421],"the":[3,8,11,15,24,29,34,36,51,74,82,86,111,126,130,135,155,161,165,191,199,225,230,246,271,274,291,305,325,360,380,426],"effect":[4,38,76,131],"radiation":[6,37,78,91,104,133,197,216,240,422],"on":[7,39,92,108,115,129,134,160,198],"heart":[9,136,200,231],"reflects":[10],"revived":[12],"interest":[13],"in":[14,57,81,188,201,224,242,261],"radiobiologic":[16],"reaction":[17,118],"normal":[19,40,116],"tissue.":[20],"As":[21,146],"early":[22,52,147],"as":[23,60,71,148,330,394,403],"first":[25,306],"two":[26,336],"decades":[27],"following":[28,268,376],"discoveries":[30],"Roentgen":[32],"and":[33,47,62,98,143,151,169,193,221,255,297,340,366,399,410],"Curies,":[35],"tissue":[41,117],"was":[42,181,293,304],"under":[43],"study.":[44],"The":[45,318],"astuteness":[46],"prophetic":[48],"vision":[49],"investigators":[53,319],"are":[54,351,363,423],"well":[55],"reflected":[56],"such":[58,393],"reports":[59],"Lacassagne":[61],"Gricouroff's":[63],"Action":[64],"des":[65],"radiations":[66],"sur":[67],"les":[68],"tissus.":[69],"Later,":[70],"knowledge":[72],"biologic":[75],"increased,":[79],"emphasis":[80],"literature":[83,128],"shifted":[84],"to":[85,183,237,270,353,388,425],"therapeutic":[87],"effects":[88,156,195],"ionizing":[90],"neoplasms.":[93],"Now,":[94],"with":[95,245,415],"improved":[96],"apparatus":[97],"technics":[99],"permitting":[100],"larger":[101],"doses":[102,214,238,420],"not":[105],"dependent":[106],"solely":[107],"skin":[109],"tolerance,":[110],"previously":[112,328],"accepted":[113],"dogma":[114],"requires":[119],"reappraisal.":[120],"An":[121],"excellent":[122],"general":[123],"review":[124],"radiologic":[127],"has":[137],"recently":[138],"been":[139,233,386],"made":[140],"by":[141,295],"Jones":[142,296,365],"Wedgwood":[144,298,367],"(2).":[145],"1897,":[149],"Sabraz\u00e8s":[150],"Rivi\u00e8re":[152],"(4)":[153],"reported":[154,190,329],"roentgen":[158,184,286,377,417],"rays":[159],"frog's":[162],"heart.":[163,427],"In":[164,252,406],"same":[166],"year,":[167],"Seguy":[168],"Qu\u00e9nisset":[170],"(5)":[171],"published":[172],"their":[173],"observations":[174],"a":[176,312],"patient":[177],"whose":[178],"precordial":[179],"region":[180],"exposed":[182],"rays.":[185],"Gloriozov":[186],"(1),":[187],"1949,":[189],"clinical":[192],"electrocardiographic":[194,263,301],"10":[202],"patients":[203,260,282],"treated":[204],"for":[205,288,299],"esophageal":[206],"or":[207,267],"lung":[208],"neoplasm.":[209],"He":[210],"concluded":[211],"that":[212,228,322,349],"large":[213,314,419],"produced":[217],"sinus":[218],"tachycardia,":[219],"extrasystoles,":[220],"degenerative":[222],"changes":[223,264,373,382],"myocardium.":[226],"Until":[227],"time,":[229],"had":[232,284],"considered":[234],"relatively":[235,313],"immune":[236],"administered":[241],"amounts":[243],"consistent":[244],"technic":[247],"those":[249],"earlier":[250],"years.":[251],"1957,":[253],"Whitfield":[254],"Kunkler":[256],"(6)":[257],"described":[258],"4":[259],"whom":[262],"developed":[265],"during":[266],"radiotherapy":[269],"thorax":[272],"including":[273],"cardiac":[275,326],"area.":[276],"A":[277],"series":[278,309],"25":[280],"female":[281],"who":[283],"received":[285],"treatment":[287],"carcinoma":[289],"breast":[292,412],"studied":[294],"nonspecific":[300,370,381],"changes.":[302],"This":[303],"carefully":[307],"observed":[308,383],"consisting":[310],"number":[315],"patients.":[317],"pointed":[320],"out":[321],"most":[323],"disturbances":[327],"resulting":[331],"from":[332],"irradiation":[333],"fit":[334],"into":[335],"groups:":[337],"(a)":[338],"arrhythmias":[339,350],"(b)":[341],"\u201cextra-cardiac":[342],"mediastinal":[343,389],"disturbances.\u201d":[344],"They":[345],"found":[346],"no":[347],"evidence":[348],"attributable":[352],"radiation;":[354],"mediastinopericardial":[355],"reactions,":[356],"which":[357],"they":[358],"consider":[359],"more":[361],"important,":[362],"rare.":[364],"also":[368],"noted":[369],"ST-T":[371],"wave":[372],"several":[374],"weeks":[375],"therapy.":[378],"Although":[379],"may":[384],"have":[385],"due":[387],"disturbances,":[390,396],"other":[391],"factors":[392],"electrolyte":[395],"positional":[397],"changes,":[398],"myocardial":[400],"damage":[401],"remain":[402],"possible":[404],"causes.":[405],"treating":[407],"intrathoracic":[408],"neoplasms":[409],"postoperative":[411],"carcinomas,":[413],"particularly":[414],"supervoltage":[416],"rays,":[418],"delivered":[424]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}