{"id":"https://openalex.org/W2036614629","doi":"https://doi.org/10.1142/9789812776303_0015","title":"BOUNDARY FORMATION BY NOTCH SIGNALING IN DROSOPHILA MULTICELLULAR SYSTEMS: EXPERIMENTAL OBSERVATIONS AND GENE NETWORK MODELING BY GENOMIC OBJECT NET","display_name":"BOUNDARY FORMATION BY NOTCH SIGNALING IN DROSOPHILA MULTICELLULAR SYSTEMS: EXPERIMENTAL OBSERVATIONS AND GENE NETWORK MODELING BY GENOMIC OBJECT NET","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2036614629","doi":"https://doi.org/10.1142/9789812776303_0015","mag":"2036614629","pmid":"https://pubmed.ncbi.nlm.nih.gov/12603025"},"language":"en","primary_location":{"id":"doi:10.1142/9789812776303_0015","doi":"https://doi.org/10.1142/9789812776303_0015","is_oa":false,"landing_page_url":"https://doi.org/10.1142/9789812776303_0015","pdf_url":null,"source":{"id":"https://openalex.org/S7407088813","display_name":"Pacific Symposium on Biocomputing (PSB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocomputing 2003","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113762836","display_name":"Hiroshi Matsuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROSHI MATSUNO","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, JapanThese authors equally contributed to this paper"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, JapanThese authors equally contributed to this paper","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108585572","display_name":"Ryutaro Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RYUTARO MURAKAMI","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, JapanThese authors equally contributed to this paper"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, JapanThese authors equally contributed to this paper","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009849195","display_name":"Rie Yamane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RIE YAMANE","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073323271","display_name":"Naoyuki Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOYUKI YAMASAKI","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103347370","display_name":"Sachie Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SACHIE FUJITA","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080274813","display_name":"Haruka Yoshimori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HARUKA YOSHIMORI","raw_affiliation_strings":["Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088167618","display_name":"Satoru Miyano","orcid":"https://orcid.org/0000-0002-1753-6616","observed_orcids":["https://orcid.org/0000-0002-1753-6616"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SATORU MIYANO","raw_affiliation_strings":["Human Genome Center, Insititute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Insititute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.9728,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.99067432,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"152","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-delta-signaling","display_name":"Delta-Notch signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/boundary-formation","display_name":"boundary formation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lateral-inhibition","display_name":"lateral inhibition","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.7160000205039978},{"id":"https://openalex.org/keywords/biosimulations","display_name":"BioSimulations","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8729294538497925},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8169423937797546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6098824739456177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5604429244995117},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.5468302965164185},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4429638087749481},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4209586977958679},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3858620226383209},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3848819136619568},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33403950929641724},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3306657671928406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29104185104370117},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/9789812776303_0015","doi":"https://doi.org/10.1142/9789812776303_0015","is_oa":false,"landing_page_url":"https://doi.org/10.1142/9789812776303_0015","pdf_url":null,"source":{"id":"https://openalex.org/S7407088813","display_name":"Pacific Symposium on Biocomputing (PSB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocomputing 2003","raw_type":"proceedings-article"},{"id":"pmid:12603025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12603025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.124.9357","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.124.9357","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://helix-web.stanford.edu/psb03/matsuno.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1674842242","https://openalex.org/W988922227","https://openalex.org/W2760081935","https://openalex.org/W3004432870","https://openalex.org/W1795574528","https://openalex.org/W7099569846","https://openalex.org/W3038786514","https://openalex.org/W1017325968","https://openalex.org/W3110183558","https://openalex.org/W193078151"],"abstract_inverted_index":{"The":[0],"Delta-Notch":[1],"signaling":[2,101],"system":[3,146],"plays":[4],"an":[5],"essential":[6,105],"role":[7],"in":[8,25,50,63,72,128,133,166],"various":[9],"morphogenetic":[10],"systems":[11,160],"of":[12,21,33,70,96,99,111,158],"multicellular":[13,159],"animal":[14],"development.":[15],"Here":[16],"we":[17],"analyzed":[18],"the":[19,26,48,57,64,85,94],"mechanism":[20],"Notch-dependent":[22],"boundary":[23,73,116],"formation":[24,46],"Drosophila":[27],"large":[28,52,65],"intestine,":[29,66],"by":[30,41,56,84,102],"experimental":[31],"manipulation":[32],"Delta":[34,61,103],"expression":[35,62],"and":[36,39,78,115,143,174],"computational":[37],"modeling":[38],"simulation":[40],"Genomic":[42,135],"Object":[43,136],"Net.":[44],"Boundary":[45],"representing":[47,93],"situation":[49],"normal":[51],"intestine":[53],"was":[54],"shown":[55],"simulation.":[58,86],"By":[59],"manipulating":[60],"a":[67,122,141],"few":[68],"types":[69],"disorder":[71],"cell":[74,167],"differentiation":[75],"were":[76,82],"observed,":[77],"similar":[79],"abnormal":[80],"patterns":[81],"generated":[83],"Simulation":[87],"results":[88,127],"suggest":[89],"that":[90,147],"parameter":[91],"values":[92],"strength":[95],"cell-autonomous":[97],"suppression":[98],"Notch":[100],"are":[104],"for":[106,150],"generating":[107],"two":[108,129],"different":[109,130],"modes":[110,132],"patterning:":[112],"lateral":[113],"inhibition":[114],"formation,":[117],"which":[118],"could":[119],"explain":[120],"how":[121],"common":[123],"gene":[124,172],"regulatory":[125],"network":[126],"patterning":[131],"vivo.":[134],"Net":[137],"proved":[138],"to":[139],"be":[140],"useful":[142],"flexible":[144],"biosimulation":[145],"is":[148],"suitable":[149],"analyzing":[151],"complex":[152],"biological":[153],"phenomena":[154],"such":[155],"as":[156,161,163],"patternings":[157],"well":[162],"intracellular":[164],"changes":[165],"states":[168],"including":[169],"metabolic":[170],"activities,":[171],"regulation,":[173],"enzyme":[175],"reactions.":[176]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
