{"id":"https://openalex.org/W2036464483","doi":"https://doi.org/10.3109/08977194.2011.599324","title":"Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferationin vitroby suppressing Sox-9 expression","display_name":"Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferationin vitroby suppressing Sox-9 expression","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W2036464483","doi":"https://doi.org/10.3109/08977194.2011.599324","mag":"2036464483","pmid":"https://pubmed.ncbi.nlm.nih.gov/21756198"},"language":"en","primary_location":{"id":"doi:10.3109/08977194.2011.599324","doi":"https://doi.org/10.3109/08977194.2011.599324","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08977194.2011.599324","pdf_url":null,"source":{"id":"https://openalex.org/S152803389","display_name":"Growth Factors","issn_l":"0897-7194","issn":["0897-7194","1026-7964","1029-2292"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth Factors","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056381851","display_name":"Moataz Elkasrawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moataz Elkasrawy","raw_affiliation_strings":["Department of Cellular Biology & Anatomy, Medical College of Georgia , Georgia Health Sciences University, Augusta, USA","Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology & Anatomy, Medical College of Georgia , Georgia Health Sciences University, Augusta, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015971774","display_name":"Sadanand Fulzele","orcid":"https://orcid.org/0000-0002-3510-6759","observed_orcids":["https://orcid.org/0000-0002-3510-6759"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadanand Fulzele","raw_affiliation_strings":["Department of Orthopaedic Surgery, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059328934","display_name":"Matthew Bowser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Bowser","raw_affiliation_strings":["Department of Cellular Biology & Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA","Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology & Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085480355","display_name":"Karl Wenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Wenger","raw_affiliation_strings":["Department of Orthopaedic Surgery, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016224286","display_name":"Mark W. Hamrick","orcid":"https://orcid.org/0000-0003-2246-3121","observed_orcids":["https://orcid.org/0000-0003-2246-3121"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark Hamrick","raw_affiliation_strings":["Cellular Biology and Anatomy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Biology and Anatomy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016224286"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6656,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82637999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"6","first_page":"253","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":1.0},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8840000033378601},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.9810346364974976},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.8939709663391113},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6616289615631104},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6126564145088196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5222107768058777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4884902238845825},{"id":"https://openalex.org/C2778486617","wikidata":"https://www.wikidata.org/wiki/Q18031654","display_name":"SOX9","level":4,"score":0.48724856972694397},{"id":"https://openalex.org/C146539212","wikidata":"https://www.wikidata.org/wiki/Q5611740","display_name":"Growth differentiation factor","level":4,"score":0.484222412109375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4702564477920532},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45495715737342834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3276330232620239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3099561333656311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18611571192741394},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18315264582633972},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.17603260278701782},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.1519138514995575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07115128636360168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061850398778915405}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3109/08977194.2011.599324","doi":"https://doi.org/10.3109/08977194.2011.599324","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08977194.2011.599324","pdf_url":null,"source":{"id":"https://openalex.org/S152803389","display_name":"Growth Factors","issn_l":"0897-7194","issn":["0897-7194","1026-7964","1029-2292"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth Factors","raw_type":"journal-article"},{"id":"pmid:21756198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21756198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth factors (Chur, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2730115","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3738019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Growth Factors","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3738019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3738019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Growth Factors","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2327451471","display_name":null,"funder_award_id":"AR 049717","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6320642772","display_name":"Effects of Myostatin Deficiency on Bone Strength","funder_award_id":"R01AR049717","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W61071114","https://openalex.org/W1544751778","https://openalex.org/W1964429509","https://openalex.org/W1965681992","https://openalex.org/W1979119154","https://openalex.org/W1981183215","https://openalex.org/W1981406615","https://openalex.org/W1982715073","https://openalex.org/W1985298426","https://openalex.org/W1987504060","https://openalex.org/W1988582146","https://openalex.org/W1990882069","https://openalex.org/W1995407442","https://openalex.org/W2001127834","https://openalex.org/W2011010606","https://openalex.org/W2013839360","https://openalex.org/W2016301193","https://openalex.org/W2022228053","https://openalex.org/W2023070796","https://openalex.org/W2027140365","https://openalex.org/W2030913739","https://openalex.org/W2034074403","https://openalex.org/W2039126271","https://openalex.org/W2047294094","https://openalex.org/W2051437976","https://openalex.org/W2053079324","https://openalex.org/W2064366726","https://openalex.org/W2083882414","https://openalex.org/W2086937196","https://openalex.org/W2088227751","https://openalex.org/W2089683126","https://openalex.org/W2090035694","https://openalex.org/W2104983126","https://openalex.org/W2108244474","https://openalex.org/W2109293470","https://openalex.org/W2121084609","https://openalex.org/W2121678285","https://openalex.org/W2123039189","https://openalex.org/W2142828130","https://openalex.org/W2144206769","https://openalex.org/W2149993139","https://openalex.org/W2151283204","https://openalex.org/W2160199212","https://openalex.org/W2163382819","https://openalex.org/W2165519158","https://openalex.org/W2470568359","https://openalex.org/W4300886612"],"related_works":["https://openalex.org/W2611431337","https://openalex.org/W2124792556","https://openalex.org/W2365399033","https://openalex.org/W2520747181","https://openalex.org/W2104983126","https://openalex.org/W2348296499","https://openalex.org/W2083045014","https://openalex.org/W1992994796","https://openalex.org/W4388468148","https://openalex.org/W2382664747"],"abstract_inverted_index":{"Here,":[0],"we":[1,12,66],"investigate":[2],"a":[3,46,92,146],"possible":[4],"direct":[5,138],"role":[6],"for":[7,150],"myostatin":[8,17,41,71,82,136],"in":[9,52,95],"chondrogenesis.":[10],"First,":[11],"examined":[13,67],"the":[14,19,68],"effects":[15,69,139],"of":[16,21,54,70,76,121],"on":[18,73,140],"proliferation":[20,53],"bone":[22,152],"marrow":[23],"stromal":[24],"cells":[25],"(BMSCs)":[26],"and":[27,58,106,127,142],"epiphyseal":[28],"growth":[29],"plate":[30],"(EGP)":[31],"chondrocytes":[32],"(EGPCs)":[33],"isolated":[34],"from":[35],"myostatin-deficient":[36],"mice.":[37],"Results":[38],"show":[39,80],"that":[40,81,135],"deficiency":[42],"is":[43],"associated":[44],"with":[45,62,125],"significant":[47,93,115],"(P":[48,103,108,116],"<":[49,104,109,117],"0.001)":[50,105],"increase":[51],"both":[55],"BMSCs":[56],"(+25%)":[57],"EGPCs":[59],"(+35%)":[60],"compared":[61],"wild-type":[63],"cells.":[64],"Next,":[65],"treatment":[72,83],"chondrogenic":[74],"differentiation":[75],"BMSCs.":[77],"These":[78],"experiments":[79],"starting":[84],"at":[85],"either":[86],"0":[87],"or":[88],"48":[89],"h":[90],"induces":[91],"decrease":[94],"collagen":[96],"type":[97],"II":[98],"protein":[99],"synthesis":[100],"by":[101],"31%":[102],"25%":[107],"0.05),":[110],"respectively.":[111],"Real-time":[112],"PCR":[113],"reveals":[114],"0.01)":[118],"down":[119],"regulation":[120],"Sox9":[122],"mRNA":[123],"expression":[124],"10":[126],"100":[128],"ng/ml":[129],"treatments.":[130],"Together,":[131],"these":[132],"findings":[133],"suggest":[134],"has":[137],"chondrogenesis,":[141],"may,":[143],"therefore,":[144],"represent":[145],"potential":[147],"therapeutic":[148],"target":[149],"improving":[151],"repair.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}