{"id":"https://openalex.org/W2036414950","doi":"https://doi.org/10.1016/0895-7061(95)00291-x","title":"Role of endogenous cardiac glycosides in the spontaneously hypertensive rat\u2014antagonism by active immunization","display_name":"Role of endogenous cardiac glycosides in the spontaneously hypertensive rat\u2014antagonism by active immunization","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2036414950","doi":"https://doi.org/10.1016/0895-7061(95)00291-x","mag":"2036414950","pmid":"https://pubmed.ncbi.nlm.nih.gov/8834711"},"language":"en","primary_location":{"id":"doi:10.1016/0895-7061(95)00291-x","doi":"https://doi.org/10.1016/0895-7061(95)00291-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0895-7061(95)00291-x","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A Nguyen","raw_affiliation_strings":["Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA","Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.2893,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62129178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"81","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-cardiac-glycosides","display_name":"endogenous cardiac glycosides","score":0.9660000205039978},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.843999981880188},{"id":"https://openalex.org/keywords/active-immunization","display_name":"active immunization","score":0.9729999899864197},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/proscillaridin","display_name":"proscillaridin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7110000252723694},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9129999876022339},{"id":"https://openalex.org/keywords/wistar-kyoto-rats","display_name":"Wistar-Kyoto rats","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8780065774917603},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.7150273323059082},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.6215402483940125},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6192529797554016},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5892502069473267},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5657013058662415},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5307042002677917},{"id":"https://openalex.org/C2778943623","wikidata":"https://www.wikidata.org/wiki/Q3425478","display_name":"Active immunization","level":4,"score":0.5231919884681702},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.4688509404659271},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.42238667607307434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41729605197906494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4143505096435547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29995858669281006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07986536622047424},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.07614567875862122},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011442","descriptor_name":"Proscillaridin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0895-7061(95)00291-x","doi":"https://doi.org/10.1016/0895-7061(95)00291-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0895-7061(95)00291-x","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:8834711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8834711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3444757380","display_name":null,"funder_award_id":"DDK45538","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W77910331","https://openalex.org/W1499796068","https://openalex.org/W1964467496","https://openalex.org/W1981194988","https://openalex.org/W1984687894","https://openalex.org/W2025829297","https://openalex.org/W2031806209","https://openalex.org/W2036745719","https://openalex.org/W2041496922","https://openalex.org/W2062763885","https://openalex.org/W2065863714","https://openalex.org/W2069595524","https://openalex.org/W2087760301","https://openalex.org/W2116503493","https://openalex.org/W2139882317","https://openalex.org/W2150708780","https://openalex.org/W2164506510","https://openalex.org/W2166523886","https://openalex.org/W2203338365","https://openalex.org/W2229815921","https://openalex.org/W2411784760","https://openalex.org/W2435519507"],"related_works":["https://openalex.org/W2391917098","https://openalex.org/W1986292558","https://openalex.org/W2379557880","https://openalex.org/W7055946485","https://openalex.org/W119701660","https://openalex.org/W1989746427","https://openalex.org/W2390837673","https://openalex.org/W2364472620","https://openalex.org/W2054834630","https://openalex.org/W2072520979"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,41,44,55,62,68,84,100,136,142],"simultaneous":[3],"active":[4,121],"immunization":[5,45,88,122],"against":[6,66,89,123],"two":[7],"cardiac":[8,90,124,144],"glycoside":[9],"drugs,":[10],"digoxin":[11],"and":[12,21],"proscillaridin,":[13],"have":[14],"been":[15],"examined":[16],"in":[17,64,97,104,131,134,146],"young":[18],"spontaneously":[19],"hypertensive":[20],"Wistar-Kyoto":[22],"rats.":[23],"Control":[24],"animals":[25,113],"were":[26,33,74],"immunized":[27],"with":[28],"protein":[29],"carrier":[30],"only.":[31],"Animals":[32],"studied":[34],"from":[35],"5":[36],"weeks":[37,40],"to":[38,46,115],"13":[39],"age.":[42],"Effectiveness":[43],"produce":[47],"antibody":[48,72],"responses":[49,73],"was":[50],"assessed":[51],"at":[52],"the":[53,56,60,69,81,105,111,132],"end":[54],"study":[57],"by":[58],"estimating":[59],"titer":[61],"antibodies":[63],"plasma":[65],"both":[67],"antigens.":[70],"Robust":[71],"obtained.":[75],"Immunization":[76],"had":[77],"no":[78],"effect":[79],"on":[80],"normal":[82],"growth":[83],"these":[85],"animals.":[86,101],"Further,":[87],"glycosides":[91,125,145],"did":[92],"not":[93,127],"change":[94],"blood":[95,129],"pressure":[96,103,130],"either":[98],"strain":[99],"Blood":[102],"SHR":[106,133],"increased":[107,140],"as":[108,110],"anticipated":[109],"weanling":[112],"grew":[114],"maturity.":[116],"These":[117],"studies":[118],"indicate":[119],"that":[120],"does":[126],"alter":[128],"spite":[135],"strong":[137],"evidence":[138],"for":[139],"levels":[141],"endogenous":[143],"this":[147],"strain.":[148]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}