{"id":"https://openalex.org/W2036157601","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","title":"Comparison of sib-pair and variance-components methods for genomic screening","display_name":"Comparison of sib-pair and variance-components methods for genomic screening","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2036157601","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","mag":"2036157601","pmid":"https://pubmed.ncbi.nlm.nih.gov/9433592"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112419294","display_name":"Elizabeth Pugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth W. Pugh","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA","National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006658658","display_name":"Cashell E. Jaquish","orcid":"https://orcid.org/0000-0003-3319-3729","observed_orcids":["https://orcid.org/0000-0003-3319-3729"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cashell E. Jaquish","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043718031","display_name":"Alexa J.M. Sorant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa J.M. Sorant","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073441791","display_name":"Jennifer P. Doetsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145561451","display_name":"McDaniel College","ror":"https://ror.org/01zc5h177","country_code":"US","type":"education","lineage":["https://openalex.org/I145561451"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer P. Doetsch","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","Western Maryland College, Westminster, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Western Maryland College, Westminster, Maryland","institution_ids":["https://openalex.org/I145561451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067921126","display_name":"Joan Wilson","orcid":"https://orcid.org/0000-0002-9153-2920","observed_orcids":["https://orcid.org/0000-0002-9153-2920"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan E. Bailey-Wilson","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091519811","display_name":"Alexander F. Wilson","orcid":"https://orcid.org/0000-0002-6682-8156","observed_orcids":["https://orcid.org/0000-0002-6682-8156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander F. Wilson","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091519811"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.6891,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83566559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"14","issue":"6","first_page":"867","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sib-pair-linkage-analysis","display_name":"sib-pair linkage analysis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/type-i-error-rate","display_name":"type I error rate","score":0.8600000143051147},{"id":"https://openalex.org/keywords/covariate-modeling","display_name":"covariate modeling","score":0.6209999918937683},{"id":"https://openalex.org/keywords/genomic-screening","display_name":"genomic screening","score":0.5370000004768372},{"id":"https://openalex.org/keywords/statistical-power-comparison","display_name":"statistical power comparison","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C3018076075","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Variance components","level":2,"score":0.7428948283195496},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5242412686347961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5205063223838806},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.4975264370441437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4961629807949066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4286264479160309},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33039796352386475},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30762386322021484},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016555","descriptor_name":"Matched-Pair Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.3.co;2-h","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.3.co;2-h","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.3.co;2-h","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:9433592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9433592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2153585430","display_name":null,"funder_award_id":"RR-03655","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2873144787","display_name":null,"funder_award_id":"HL-28972","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2882500740","display_name":"Human Genetic Analysis Resource","funder_award_id":"P41RR003655","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6843954451","display_name":"Diet and Genotype in Primate Atherosclerosis","funder_award_id":"P01HL028972","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7144679236","display_name":null,"funder_award_id":"GM-31575","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G736005061","display_name":"Genetic Analysis of Common Diseases: An Evaluation","funder_award_id":"R01GM031575","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1765369324","https://openalex.org/W1953663792","https://openalex.org/W1976741643","https://openalex.org/W1977104259","https://openalex.org/W2987011813"],"related_works":["https://openalex.org/W2092184151","https://openalex.org/W1981240084","https://openalex.org/W1983971027","https://openalex.org/W7098207045","https://openalex.org/W1885715880","https://openalex.org/W2077965482","https://openalex.org/W1601943383","https://openalex.org/W1989656083","https://openalex.org/W2162402894","https://openalex.org/W1981958843"],"abstract_inverted_index":{"The":[0,31],"statistical":[1],"properties":[2],"of":[3,39],"sib-pair":[4],"and":[5],"variance-components":[6,32],"linkage":[7,24],"methods":[8],"were":[9,44,53],"compared":[10],"using":[11],"the":[12,20,47],"nuclear":[13],"family":[14],"data":[15],"from":[16],"Problem":[17],"2.":[18],"Overall,":[19],"power":[21,36],"to":[22,55],"detect":[23],"was":[25],"not":[26],"high":[27],"for":[28,37,59],"either":[29],"method.":[30],"method":[33],"had":[34],"better":[35],"detection":[38],"linkage,":[40],"particularly":[41],"when":[42],"covariates":[43],"included":[45],"in":[46],"model.":[48],"Type":[49],"I":[50],"error":[51,57],"rates":[52,58],"similar":[54],"nominal":[56],"both":[60],"methods.":[61]},"counts_by_year":[{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
