{"id":"https://openalex.org/W2036090573","doi":"https://doi.org/10.1371/journal.pone.0075896","title":"Highly Efficient Retrograde Gene Transfer into Motor Neurons by a Lentiviral Vector Pseudotyped with Fusion Glycoprotein","display_name":"Highly Efficient Retrograde Gene Transfer into Motor Neurons by a Lentiviral Vector Pseudotyped with Fusion Glycoprotein","publication_year":2013,"publication_date":"2013-09-24","ids":{"openalex":"https://openalex.org/W2036090573","doi":"https://doi.org/10.1371/journal.pone.0075896","mag":"2036090573","pmid":"https://pubmed.ncbi.nlm.nih.gov/24086660","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782444"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0075896","doi":"https://doi.org/10.1371/journal.pone.0075896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075896","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075896&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075896&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073361589","display_name":"Miyabi Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyabi Hirano","raw_affiliation_strings":["Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089908182","display_name":"Shigeki Kato","orcid":"https://orcid.org/0000-0002-8792-7591","observed_orcids":["https://orcid.org/0000-0002-8792-7591"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Kato","raw_affiliation_strings":["Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081667624","display_name":"Kenta Kobayashi","orcid":"https://orcid.org/0000-0002-7389-3693","observed_orcids":["https://orcid.org/0000-0002-7389-3693"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Kobayashi","raw_affiliation_strings":["Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan","Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","Section of Viral Vector Development, National Institute of Physiological Sciences, Okazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Section of Viral Vector Development, National Institute of Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoaki Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Okada","raw_affiliation_strings":["Department of Neuroanatomy & Embryology, Fukushima Medical University School of Medicine, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy & Embryology, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006470202","display_name":"Hiroyuki Yaginuma","orcid":"https://orcid.org/0000-0002-5453-4484","observed_orcids":["https://orcid.org/0000-0002-5453-4484"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yaginuma","raw_affiliation_strings":["Department of Neuroanatomy & Embryology, Fukushima Medical University School of Medicine, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy & Embryology, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kazuto Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuto Kobayashi","raw_affiliation_strings":["Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan","Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","Section of Viral Vector Development, National Institute of Physiological Sciences, Okazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Section of Viral Vector Development, National Institute of Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130830085","https://openalex.org/I4210086780","https://openalex.org/I4210145863"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6318,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9012168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"8","issue":"9","first_page":"e75896","last_page":"e75896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rabies-virus-glycoprotein","display_name":"rabies virus glycoprotein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vsv-g","display_name":"vesicular stomatitis virus glycoprotein","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hiv-1-based-vectors","display_name":"HIV-1-based vectors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.8040000200271606},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.6539999842643738},{"id":"https://openalex.org/keywords/hindbrain","display_name":"hindbrain","score":0.9769999980926514},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.875},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.7119598388671875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5633146166801453},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.5315567851066589},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5251248478889465},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49584826827049255},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.47399961948394775},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.41567832231521606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38854461908340454},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2734680771827698},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23548623919487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17178508639335632},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014760","descriptor_name":"Viral Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014760","descriptor_name":"Viral Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0075896","doi":"https://doi.org/10.1371/journal.pone.0075896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075896","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075896&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2780891","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3782444","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3782444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24086660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24086660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.809.5024","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.809.5024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/79/c5/pone.0075896.PMC3782444.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bbf313c17bd64d34be1c78b0b5c94524","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bbf313c17bd64d34be1c78b0b5c94524","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e75896 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0075896","doi":"https://doi.org/10.1371/journal.pone.0075896","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075896","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075896&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7372175809","display_name":"Analysis of specific neural pathway using double viral vector system","funder_award_id":"25560436","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309515","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2036090573.pdf","grobid_xml":"https://content.openalex.org/works/W2036090573.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1970761063","https://openalex.org/W1973349095","https://openalex.org/W1974448552","https://openalex.org/W1978227190","https://openalex.org/W1981449360","https://openalex.org/W1982076909","https://openalex.org/W1986511337","https://openalex.org/W1988057772","https://openalex.org/W1989815073","https://openalex.org/W1991479954","https://openalex.org/W1992180259","https://openalex.org/W2002197824","https://openalex.org/W2002403174","https://openalex.org/W2014040194","https://openalex.org/W2016378555","https://openalex.org/W2020423027","https://openalex.org/W2020893142","https://openalex.org/W2033528933","https://openalex.org/W2045242923","https://openalex.org/W2048162805","https://openalex.org/W2050870581","https://openalex.org/W2052064543","https://openalex.org/W2055456084","https://openalex.org/W2058327648","https://openalex.org/W2060106616","https://openalex.org/W2064640860","https://openalex.org/W2067287844","https://openalex.org/W2069519855","https://openalex.org/W2071591138","https://openalex.org/W2072981065","https://openalex.org/W2077770544","https://openalex.org/W2082328650","https://openalex.org/W2091488679","https://openalex.org/W2094666622","https://openalex.org/W2103616205","https://openalex.org/W2109971716","https://openalex.org/W2113409179","https://openalex.org/W2114205243","https://openalex.org/W2121589650","https://openalex.org/W2122432632","https://openalex.org/W2135136739","https://openalex.org/W2141335195","https://openalex.org/W2151102772","https://openalex.org/W2157890177","https://openalex.org/W2158920269","https://openalex.org/W2169915056","https://openalex.org/W4232115993"],"related_works":["https://openalex.org/W7099123188","https://openalex.org/W2081056077","https://openalex.org/W2918838410","https://openalex.org/W2020423027","https://openalex.org/W2016378555","https://openalex.org/W1548759173","https://openalex.org/W1970761063","https://openalex.org/W2002403174","https://openalex.org/W1973349095","https://openalex.org/W4319317067"],"abstract_inverted_index":{"The":[0,212],"development":[1],"of":[2,26,87,95,103,132,139,147,156,172,204,208,215,250],"gene":[3,44,65,118,158,182,228,244],"therapy":[4],"techniques":[5],"to":[6],"introduce":[7],"transgenes":[8],"that":[9,219],"promote":[10],"neuronal":[11,162],"survival":[12],"and":[13,21,28,136,177,191,198,234],"protection":[14],"provides":[15],"effective":[16],"therapeutic":[17,245],"approaches":[18],"for":[19,52,180,247],"neurological":[20],"neurodegenerative":[22],"diseases.":[23,55,253],"Intramuscular":[24],"injection":[25,197],"adenoviral":[27],"adeno-associated":[29],"viral":[30],"vectors,":[31],"as":[32,34,242],"well":[33],"lentiviral":[35],"vectors":[36,151,179],"pseudotyped":[37],"with":[38,61,78,121,143,201],"rabies":[39],"virus":[40,73,106],"glycoprotein":[41,80,107,123],"(RV-G),":[42],"permits":[43],"delivery":[45],"into":[46,160,184,230],"motor":[47,53,185,236,251],"neurons":[48,186],"in":[49,90,126,164,187,193],"animal":[50],"models":[51],"neuron":[54,252],"Recently,":[56],"we":[57,168],"developed":[58,112],"a":[59,70,85,243],"vector":[60,77,114,222],"highly":[62],"efficient":[63,226],"retrograde":[64,117,157,181,227],"transfer":[66,119,159,183,229],"(HiRet)":[67],"by":[68,99],"pseudotyping":[69],"human":[71],"immunodeficiency":[72],"type":[74,82],"1":[75],"(HIV-1)-based":[76],"fusion":[79,122],"B":[81],"(FuG-B)":[83],"or":[84],"variant":[86],"FuG-B":[88],"(FuG-B2),":[89],"which":[91,127],"the":[92,100,128,133,144,153,165,170,173,188,202,205,209,220,224,248],"cytoplasmic":[93],"domain":[94,135],"RV-G":[96,140,206],"was":[97,141],"replaced":[98],"corresponding":[101,145],"part":[102],"vesicular":[104],"stomatitis":[105],"(VSV-G).":[108],"We":[109],"have":[110],"also":[111],"another":[113],"showing":[115],"neuron-specific":[116],"(NeuRet)":[120],"C":[124],"type,":[125],"short":[129],"C-terminal":[130],"segment":[131],"extracellular":[134],"transmembrane/cytoplasmic":[137],"domains":[138],"substituted":[142],"regions":[146],"VSV-G.":[148],"These":[149],"two":[150],"afford":[152],"high":[154],"efficiency":[155,171,203],"different":[161],"populations":[163],"brain.":[166],"Here":[167],"investigated":[169],"HiRet":[174,221],"(with":[175],"FuG-B2)":[176],"NeuRet":[178],"spinal":[189,232],"cord":[190,233],"hindbrain":[192,235],"mice":[194],"after":[195],"intramuscular":[196],"compared":[199],"it":[200],"pseudotype":[207],"HIV-1-based":[210],"vector.":[211],"main":[213],"highlight":[214],"our":[216],"results":[217],"is":[218],"shows":[223],"most":[225],"both":[231],"neurons,":[237],"offering":[238],"its":[239],"promising":[240],"use":[241],"approach":[246],"treatment":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}