{"id":"https://openalex.org/W2036074652","doi":"https://doi.org/10.1210/en.2011-1641","title":"The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat","display_name":"The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W2036074652","doi":"https://doi.org/10.1210/en.2011-1641","mag":"2036074652","pmid":"https://pubmed.ncbi.nlm.nih.gov/22109887"},"language":"en","primary_location":{"id":"doi:10.1210/en.2011-1641","doi":"https://doi.org/10.1210/en.2011-1641","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2011-1641","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058976322","display_name":"James S. Kinsey\u2010Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James S. Kinsey-Jones","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017697218","display_name":"Pasha Grachev","orcid":"https://orcid.org/0000-0002-6611-6423","observed_orcids":["https://orcid.org/0000-0002-6611-6423"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pasha Grachev","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101898660","display_name":"Xiao Feng Li","orcid":"https://orcid.org/0000-0001-9974-1340","observed_orcids":["https://orcid.org/0000-0001-9974-1340"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiao Feng Li","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001220476","display_name":"Yuan Shao Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yuan Shao Lin","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110135144","display_name":"Stuart R. Milligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart R. Milligan","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017571758","display_name":"Stafford Louis Lightman","orcid":"https://orcid.org/0000-0002-8546-9646","observed_orcids":["https://orcid.org/0000-0002-8546-9646"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stafford L. Lightman","raw_affiliation_strings":["Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology (S.L.L.), University of Bristol, Bristol BS1 3NY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology (S.L.L.), University of Bristol, Bristol BS1 3NY, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kevin T. O'Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kevin T. O'Byrne","raw_affiliation_strings":["Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health (J.S.K.-J., P.G., X.F.L., Y.S.L., S.R.M., K.T.O.), School of Medicine, King's College London, London SE1 1UL, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":14.0234,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.9946065,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"153","issue":"1","first_page":"307","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurokinin-b","display_name":"neurokinin B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neurokinin-3-receptor","display_name":"neurokinin-3 receptor","score":0.968999981880188},{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dynorphin-a","display_name":"dynorphin A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gnrh-pulse-generator","display_name":"GnRH pulse generator","score":0.8119999766349792},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.8389999866485596},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.7200000286102295},{"id":"https://openalex.org/keywords/senktide","display_name":"senktide","score":0.6700000166893005},{"id":"https://openalex.org/keywords/nor-binaltorphimine","display_name":"nor-binaltorphimine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gonadotropin-regulation","display_name":"gonadotropin regulation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7660865783691406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7632606625556946},{"id":"https://openalex.org/C2781359426","wikidata":"https://www.wikidata.org/wiki/Q412604","display_name":"Neurokinin B","level":5,"score":0.733240008354187},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5790656805038452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4315895736217499},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.43135374784469604},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.42122000455856323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35711485147476196},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2696588635444641},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.23779815435409546},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16528210043907166},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.15949541330337524}],"mesh":[{"descriptor_ui":"D000074502","descriptor_name":"Receptors, Kisspeptin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015287","descriptor_name":"Neurokinin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015287","descriptor_name":"Neurokinin B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018042","descriptor_name":"Receptors, Neurokinin-3","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018042","descriptor_name":"Receptors, Neurokinin-3","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059648","descriptor_name":"Kisspeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D059648","descriptor_name":"Kisspeptins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1210/en.2011-1641","doi":"https://doi.org/10.1210/en.2011-1641","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2011-1641","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:22109887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22109887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/b36d6824-d5d3-4f27-852f-5490ccbb5431","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/b36d6824-d5d3-4f27-852f-5490ccbb5431","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kinsey-Jones, J S, Grachev, P, Li, X F, Lin, Y S, Milligan, S R, Lightman, S L & O'Byrne, K 2012, 'The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat', Endocrinology, vol. 153, no. 1, pp. 307-315. https://doi.org/10.1210/en.2011-1641","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/59205add-0266-4edc-90ca-1684404e605b","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/59205add-0266-4edc-90ca-1684404e605b","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kinsey-Jones, JS, Grachev, P, Li, XF, Lin, YS, Milligan, SR, Lightman, SL & O'Byrne, KT 2012, 'The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat', Endocrinology, vol. 153(1), pp. 307 - 315. https://doi.org/10.1210/en.2011-1641","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:publications/59205add-0266-4edc-90ca-1684404e605b","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/59205add-0266-4edc-90ca-1684404e605b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kinsey-Jones, JS, Grachev, P, Li, XF, Lin, YS, Milligan, SR, Lightman, SL & O'Byrne, KT 2012, 'The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat', Endocrinology, vol. 153(1), pp. 307 - 315. https://doi.org/10.1210/en.2011-1641","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1432312346","display_name":"Stress and timing of puberty: is the amygdala the key?","funder_award_id":"BB/J002232/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320329004","display_name":"Wockhardt","ror":"https://ror.org/01djxaj77"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W77861502","https://openalex.org/W1535081228","https://openalex.org/W1553971595","https://openalex.org/W1964637416","https://openalex.org/W1972602091","https://openalex.org/W1977013546","https://openalex.org/W1977250427","https://openalex.org/W1977865535","https://openalex.org/W1977946309","https://openalex.org/W1989667491","https://openalex.org/W1997729333","https://openalex.org/W2006219321","https://openalex.org/W2010920434","https://openalex.org/W2012579732","https://openalex.org/W2019097241","https://openalex.org/W2026612675","https://openalex.org/W2030585597","https://openalex.org/W2045555035","https://openalex.org/W2051122851","https://openalex.org/W2056779380","https://openalex.org/W2082115843","https://openalex.org/W2092614270","https://openalex.org/W2100335727","https://openalex.org/W2163815564","https://openalex.org/W2164127780","https://openalex.org/W2168312980"],"related_works":["https://openalex.org/W2097876705","https://openalex.org/W7100498243","https://openalex.org/W2946859617","https://openalex.org/W2164127780","https://openalex.org/W2125072756","https://openalex.org/W1982410791","https://openalex.org/W2045555035","https://openalex.org/W4200452029","https://openalex.org/W7143654498","https://openalex.org/W1973563914"],"abstract_inverted_index":{"Neurokinin":[0],"B":[1],"(NKB)":[2],"and":[3,12,46,61,72,82,155,168,211],"its":[4],"receptor":[5,143,177],"(neurokinin-3":[6],"receptor)":[7,180],"are":[8],"coexpressed":[9],"with":[10,79,102,121,134,173],"kisspeptin":[11,208,214],"dynorphin":[13],"A":[14,113],"(Dyn)":[15],"within":[16],"neurons":[17],"of":[18,26,57,116,127,139,152,161,189,195,207,219,230],"the":[19,23,27,43,66,69,125,140,186,200,216,228,231],"hypothalamic":[20],"arcuate":[21],"nucleus,":[22],"suggested":[24],"site":[25],"GnRH":[28,232],"pulse":[29,233],"generator.":[30],"It":[31],"is":[32],"thought":[33],"that":[34,225],"these":[35],"neuropeptides":[36],"interact":[37],"to":[38,64],"regulate":[39],"gonadotropin":[40],"secretion.":[41,192],"Using":[42],"ovariectomized":[44],"(OVX)":[45],"OVX":[47,117,167,170],"17\u03b2-estradiol-replaced":[48,169],"rat":[49],"models,":[50],"we":[51],"have":[52],"carried":[53],"out":[54],"a":[55,108,149,174,236],"series":[56],"in":[58,202,235],"vivo":[59],"neuropharmacological":[60],"electrophysiological":[62],"experiments":[63],"elucidate":[65],"hierarchy":[67],"between":[68,166],"kisspeptin,":[70],"NKB,":[71],"Dyn":[73,176],"signaling":[74],"systems.":[75],"Rats":[76],"were":[77,97],"implanted":[78,120],"intracerebroventricular":[80,103],"cannulae":[81],"cardiac":[83],"catheters":[84],"for":[85,99,124],"frequent":[86],"(every":[87],"5":[88],"min)":[89],"automated":[90],"serial":[91],"blood":[92],"sampling.":[93],"Freely":[94],"moving":[95],"rats":[96,118],"bled":[98],"6":[100],"h,":[101],"injections":[104],"taking":[105],"place":[106],"after":[107,205],"2-h":[109],"control":[110],"bleeding":[111],"period.":[112],"further":[114],"group":[115],"was":[119],"intra-arcuate":[122],"electrodes":[123],"recording":[126],"multiunit":[128,156],"activity":[129,157],"volleys,":[130],"which":[131],"coincide":[132],"invariably":[133],"LH":[135,153,191,203,220],"pulses.":[136,221],"Intracerebroventricular":[137,193],"administration":[138,206],"selective":[141,175],"neurokinin-3":[142],"agonist,":[144],"senktide":[145,162,196],"(100-600":[146],"pmol),":[147],"caused":[148],"dose-dependent":[150],"suppression":[151,218],"pulses":[154],"volleys.":[158],"The":[159],"effects":[160],"did":[163,197,213],"not":[164,198],"differ":[165],"animals.":[171],"Pretreatment":[172],"(\u03ba":[178],"opioid":[179,238],"antagonist,":[181],"norbinaltorphimine":[182],"(6.8":[183],"nmol),":[184,210],"blocked":[185],"senktide-induced":[187,217],"inhibition":[188],"pulsatile":[190],"injection":[194],"affect":[199],"rise":[201],"concentrations":[204],"(1":[209],"neither":[212],"preclude":[215],"These":[222],"data":[223],"show":[224],"NKB":[226],"suppresses":[227],"frequency":[229],"generator":[234],"Dyn/\u03ba":[237],"receptor-dependent":[239],"fashion.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}