{"id":"https://openalex.org/W2036065063","doi":"https://doi.org/10.1007/s00044-011-9956-y","title":"Amino acid and peptide esters of abacavir: synthesis and activity against human immunodeficiency virus type 1 in cell culture","display_name":"Amino acid and peptide esters of abacavir: synthesis and activity against human immunodeficiency virus type 1 in cell culture","publication_year":2011,"publication_date":"2011-12-24","ids":{"openalex":"https://openalex.org/W2036065063","doi":"https://doi.org/10.1007/s00044-011-9956-y","mag":"2036065063"},"language":"en","primary_location":{"id":"doi:10.1007/s00044-011-9956-y","doi":"https://doi.org/10.1007/s00044-011-9956-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-011-9956-y","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029259516","display_name":"Ivanka G. Stankova","orcid":"https://orcid.org/0000-0002-2750-5813","observed_orcids":["https://orcid.org/0000-0002-2750-5813"]},"institutions":[{"id":"https://openalex.org/I168129107","display_name":"South-West University \"Neofit Rilski\"","ror":"https://ror.org/002wcjr61","country_code":"BG","type":"education","lineage":["https://openalex.org/I168129107"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ivanka Stankova","raw_affiliation_strings":["Department of Chemistry, South-West University \u201cNeofit Rilski\u201d, Blagoevgrad, Bulgaria","South-West University \u201cNeofit Rilski\u201c"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, South-West University \u201cNeofit Rilski\u201d, Blagoevgrad, Bulgaria","institution_ids":["https://openalex.org/I168129107"]},{"raw_affiliation_string":"South-West University \u201cNeofit Rilski\u201c","institution_ids":["https://openalex.org/I168129107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031080882","display_name":"Kamelia R. Stanoeva","orcid":"https://orcid.org/0000-0002-9518-5102","observed_orcids":["https://orcid.org/0000-0002-9518-5102"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]},{"id":"https://openalex.org/I58918642","display_name":"Sofia University \"St. Kliment Ohridski\"","ror":"https://ror.org/02jv3k292","country_code":"BG","type":"education","lineage":["https://openalex.org/I58918642"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Kamelia Stanoeva","raw_affiliation_strings":["Faculty of Biology, Sofia University \u201cSt. Kliment Ohridski\u201d, Sofia, Bulgaria","Medical Faculty, Medical University of Sofia, Sofia, Bulgaria","Medical University of Sofia","Sofia University \u201cSt. Kliment Ohridski\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Sofia University \u201cSt. Kliment Ohridski\u201d, Sofia, Bulgaria","institution_ids":["https://openalex.org/I58918642"]},{"raw_affiliation_string":"Medical Faculty, Medical University of Sofia, Sofia, Bulgaria","institution_ids":["https://openalex.org/I30147112"]},{"raw_affiliation_string":"Medical University of Sofia","institution_ids":["https://openalex.org/I30147112"]},{"raw_affiliation_string":"Sofia University \u201cSt. Kliment Ohridski\u201d","institution_ids":["https://openalex.org/I58918642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085517722","display_name":"Anton V. Hinkov","orcid":"https://orcid.org/0000-0003-2058-8983","observed_orcids":["https://orcid.org/0000-0003-2058-8983"]},"institutions":[{"id":"https://openalex.org/I58918642","display_name":"Sofia University \"St. Kliment Ohridski\"","ror":"https://ror.org/02jv3k292","country_code":"BG","type":"education","lineage":["https://openalex.org/I58918642"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Anton Hinkov","raw_affiliation_strings":["Faculty of Biology, Sofia University \u201cSt. Kliment Ohridski\u201d, Sofia, Bulgaria","Sofia University, \u201cSt. Kliment Ohridski\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Sofia University \u201cSt. Kliment Ohridski\u201d, Sofia, Bulgaria","institution_ids":["https://openalex.org/I58918642"]},{"raw_affiliation_string":"Sofia University, \u201cSt. Kliment Ohridski\u201d","institution_ids":["https://openalex.org/I58918642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069747820","display_name":"Ivailo Alexiev","orcid":"https://orcid.org/0000-0002-3186-1124","observed_orcids":["https://orcid.org/0000-0002-3186-1124"]},"institutions":[{"id":"https://openalex.org/I4210165578","display_name":"National Center of Infectious and Parasitic Diseases","ror":"https://ror.org/05vv5ch57","country_code":"BG","type":"education","lineage":["https://openalex.org/I4210165578"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ivailo Alexiev","raw_affiliation_strings":["National HIV Confirmation Laboratory, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria","National Center of Infectious and Parasitic Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National HIV Confirmation Laboratory, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210165578"]},{"raw_affiliation_string":"National Center of Infectious and Parasitic Diseases","institution_ids":["https://openalex.org/I4210165578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039137817","display_name":"Petya D. Genova-Kalou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165578","display_name":"National Center of Infectious and Parasitic Diseases","ror":"https://ror.org/05vv5ch57","country_code":"BG","type":"education","lineage":["https://openalex.org/I4210165578"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Petya Genova-Kalou","raw_affiliation_strings":["Lab for Cell Cultures, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria","National Center of Infectious and Parasitic Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab for Cell Cultures, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210165578"]},{"raw_affiliation_string":"National Center of Infectious and Parasitic Diseases","institution_ids":["https://openalex.org/I4210165578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027720141","display_name":"Radoslav Chayrov","orcid":"https://orcid.org/0000-0002-2522-7020","observed_orcids":["https://orcid.org/0000-0002-2522-7020"]},"institutions":[{"id":"https://openalex.org/I168129107","display_name":"South-West University \"Neofit Rilski\"","ror":"https://ror.org/002wcjr61","country_code":"BG","type":"education","lineage":["https://openalex.org/I168129107"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Radoslav Chayrov","raw_affiliation_strings":["Department of Chemistry, South-West University \u201cNeofit Rilski\u201d, Blagoevgrad, Bulgaria","South-West University \u201cNeofit Rilski\u201c"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, South-West University \u201cNeofit Rilski\u201d, Blagoevgrad, Bulgaria","institution_ids":["https://openalex.org/I168129107"]},{"raw_affiliation_string":"South-West University \u201cNeofit Rilski\u201c","institution_ids":["https://openalex.org/I168129107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090809967","display_name":"Radka M. Argirova","orcid":"https://orcid.org/0000-0002-6163-2269","observed_orcids":["https://orcid.org/0000-0002-6163-2269"]},"institutions":[{"id":"https://openalex.org/I4210165578","display_name":"National Center of Infectious and Parasitic Diseases","ror":"https://ror.org/05vv5ch57","country_code":"BG","type":"education","lineage":["https://openalex.org/I4210165578"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Radka Argirova","raw_affiliation_strings":["Laboratory of Retroviruses, National Center for Infectious and Parasitic Diseases, 44A, Stoletov Str, 1233, Sofia, Bulgaria","National Center for Infectious and Parasitic Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Retroviruses, National Center for Infectious and Parasitic Diseases, 44A, Stoletov Str, 1233, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210165578"]},{"raw_affiliation_string":"National Center for Infectious and Parasitic Diseases","institution_ids":["https://openalex.org/I4210165578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090809967"],"corresponding_institution_ids":["https://openalex.org/I4210165578"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.217,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55654159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"12","first_page":"4053","last_page":"4059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abacavir","display_name":"abacavir","score":0.949999988079071},{"id":"https://openalex.org/keywords/amino-acid-esters","display_name":"amino acid esters","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dipeptide-esters","display_name":"dipeptide esters","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glycine-esters","display_name":"glycine esters","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/antiretroviral-activity","display_name":"antiretroviral activity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mt-4-cells","display_name":"MT-4 cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6330000162124634},{"id":"https://openalex.org/keywords/structural-modification","display_name":"structural modification","score":0.5059999823570251},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.8897433280944824},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.8337886333465576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.776157021522522},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.7488919496536255},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5967482328414917},{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.5823495388031006},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5703206062316895},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5652343034744263},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.48500773310661316},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.41659313440322876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4061353802680969},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3856785297393799},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.366447389125824},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29488199949264526},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17677095532417297},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.11127251386642456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10564735531806946},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.07751986384391785}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00044-011-9956-y","doi":"https://doi.org/10.1007/s00044-011-9956-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-011-9956-y","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W56727962","https://openalex.org/W1778074134","https://openalex.org/W1968348763","https://openalex.org/W2008681391","https://openalex.org/W2012842150","https://openalex.org/W2019894676","https://openalex.org/W2026364655","https://openalex.org/W2027896347","https://openalex.org/W2036223783","https://openalex.org/W2053360465","https://openalex.org/W2055078358","https://openalex.org/W2058676238","https://openalex.org/W2112182958","https://openalex.org/W2114918609","https://openalex.org/W2123297055","https://openalex.org/W2255539187","https://openalex.org/W2422087709","https://openalex.org/W2423137336"],"related_works":["https://openalex.org/W7132221944","https://openalex.org/W73588375","https://openalex.org/W2094065609","https://openalex.org/W1739299836","https://openalex.org/W2081583561","https://openalex.org/W2905236656","https://openalex.org/W1982940175","https://openalex.org/W3016915813","https://openalex.org/W2334478510","https://openalex.org/W2075448036"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}