{"id":"https://openalex.org/W2036005489","doi":"https://doi.org/10.1038/ncomms3087","title":"CRISPR-Cas and restriction\u2013modification systems are compatible and increase phage resistance","display_name":"CRISPR-Cas and restriction\u2013modification systems are compatible and increase phage resistance","publication_year":2013,"publication_date":"2013-07-02","ids":{"openalex":"https://openalex.org/W2036005489","doi":"https://doi.org/10.1038/ncomms3087","mag":"2036005489","pmid":"https://pubmed.ncbi.nlm.nih.gov/23820428"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms3087","doi":"https://doi.org/10.1038/ncomms3087","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms3087","pdf_url":"https://www.nature.com/articles/ncomms3087.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/ncomms3087.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111944214","display_name":"Marie-\u00c8ve Dupuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-\u00c8ve Dupuis","raw_affiliation_strings":["D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, Quebec, Canada G1V 0A6","D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, Quebec, Canada G1V 0A6","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013691408","display_name":"Manuela Villion","orcid":"https://orcid.org/0000-0001-6254-3156","observed_orcids":["https://orcid.org/0000-0001-6254-3156"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Manuela Villion","raw_affiliation_strings":["D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050524015","display_name":"Alfonso H. Magad\u00e1n","orcid":"https://orcid.org/0000-0003-2556-7890","observed_orcids":["https://orcid.org/0000-0003-2556-7890"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alfonso H. Magad\u00e1n","raw_affiliation_strings":["D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079257651","display_name":"Sylvain Moineau","orcid":"https://orcid.org/0000-0002-2832-5101","observed_orcids":["https://orcid.org/0000-0002-2832-5101"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sylvain Moineau","raw_affiliation_strings":["D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","F\u00e9lix d\u2019H\u00e9relle Reference Center for Bacterial Viruses, Quebec City, G1V 0A6, Quebec, Canada","Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biochimie, de Microbiologie et de Bio-informatique, Facult\u00e9 des Sciences et de G\u00e9nie, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"F\u00e9lix d\u2019H\u00e9relle Reference Center for Bacterial Viruses, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":[]},{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, Quebec City, G1V 0A6, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079257651"],"corresponding_institution_ids":["https://openalex.org/I43406934"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":null,"fwci":4.2345,"has_fulltext":true,"cited_by_count":297,"citation_normalized_percentile":{"value":0.96069364,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"2087","last_page":"2087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.1842000037431717,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas-systems","display_name":"CRISPR-Cas","score":0.9750000238418579},{"id":"https://openalex.org/keywords/restriction-modification-systems","display_name":"restriction-modification systems","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phage-resistance","display_name":"phage resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/streptococcus-thermophilus","display_name":"Streptococcus thermophilus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.640999972820282},{"id":"https://openalex.org/keywords/phage-contamination","display_name":"phage contamination","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.890998363494873},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7479652762413025},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6621118783950806},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5733543634414673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5691947340965271},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.47619926929473877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44303956627845764},{"id":"https://openalex.org/C103244968","wikidata":"https://www.wikidata.org/wiki/Q273193","display_name":"Bacterial conjugation","level":4,"score":0.44283249974250793},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4397367835044861},{"id":"https://openalex.org/C10079403","wikidata":"https://www.wikidata.org/wiki/Q424475","display_name":"Phagemid","level":5,"score":0.4227983355522156},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.3298148512840271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.324523389339447},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1480793058872223}],"mesh":[{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015280","descriptor_name":"DNA Restriction-Modification Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048249","descriptor_name":"Streptococcus thermophilus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D053837","descriptor_name":"DNA Cleavage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/ncomms3087","doi":"https://doi.org/10.1038/ncomms3087","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms3087","pdf_url":"https://www.nature.com/articles/ncomms3087.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:23820428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23820428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3087","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms3087","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/38540","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/38540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article de recherche"}],"best_oa_location":{"id":"doi:10.1038/ncomms3087","doi":"https://doi.org/10.1038/ncomms3087","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms3087","pdf_url":"https://www.nature.com/articles/ncomms3087.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2980201894","display_name":null,"funder_award_id":"Tier 1","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2036005489.pdf","grobid_xml":"https://content.openalex.org/works/W2036005489.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1612454453","https://openalex.org/W1968582377","https://openalex.org/W1972708645","https://openalex.org/W1976391205","https://openalex.org/W1976778748","https://openalex.org/W1978094899","https://openalex.org/W1984197290","https://openalex.org/W2000046950","https://openalex.org/W2002534691","https://openalex.org/W2003171404","https://openalex.org/W2005031387","https://openalex.org/W2019197162","https://openalex.org/W2029926937","https://openalex.org/W2043083543","https://openalex.org/W2045435533","https://openalex.org/W2047032063","https://openalex.org/W2054140474","https://openalex.org/W2060573994","https://openalex.org/W2063148079","https://openalex.org/W2064815984","https://openalex.org/W2087712940","https://openalex.org/W2095624846","https://openalex.org/W2104648253","https://openalex.org/W2104821962","https://openalex.org/W2113677672","https://openalex.org/W2115420193","https://openalex.org/W2122773612","https://openalex.org/W2131730777","https://openalex.org/W2135598273","https://openalex.org/W2140590832","https://openalex.org/W2141589508","https://openalex.org/W2143527741","https://openalex.org/W2143554177","https://openalex.org/W2149751339","https://openalex.org/W2157266312","https://openalex.org/W2159218142","https://openalex.org/W2160051211","https://openalex.org/W2163241233","https://openalex.org/W2164670841","https://openalex.org/W2168933209","https://openalex.org/W2169244146","https://openalex.org/W2171786959","https://openalex.org/W2179631201","https://openalex.org/W4246188361"],"related_works":["https://openalex.org/W3087407932","https://openalex.org/W7080496734","https://openalex.org/W4412940614","https://openalex.org/W4224272231","https://openalex.org/W2143554177","https://openalex.org/W7221497364","https://openalex.org/W303704380","https://openalex.org/W4210903075","https://openalex.org/W1978094899","https://openalex.org/W2124638114"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}