{"id":"https://openalex.org/W2035985010","doi":"https://doi.org/10.1126/science.3576226","title":"Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene","display_name":"Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene","publication_year":1987,"publication_date":"1987-05-29","ids":{"openalex":"https://openalex.org/W2035985010","doi":"https://doi.org/10.1126/science.3576226","mag":"2035985010","pmid":"https://pubmed.ncbi.nlm.nih.gov/3576226"},"language":"en","primary_location":{"id":"doi:10.1126/science.3576226","doi":"https://doi.org/10.1126/science.3576226","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3576226","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079051183","display_name":"Yoshitaka Ono","orcid":"https://orcid.org/0000-0002-8247-7245","observed_orcids":["https://orcid.org/0000-0002-8247-7245"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Ono","raw_affiliation_strings":["Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072164143","display_name":"Ushio Kikkawa","orcid":"https://orcid.org/0000-0002-0744-6596","observed_orcids":["https://orcid.org/0000-0002-0744-6596"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ushio Kikkawa","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065708990","display_name":"Kouji Ogita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouji Ogita","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoko Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Fujii","raw_affiliation_strings":["Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108366957","display_name":"Tsutomu Kurokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Kurokawa","raw_affiliation_strings":["Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027548277","display_name":"Yoshinori Asaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Asaoka","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401014","display_name":"Kazuo Sekiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Sekiguchi","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041910615","display_name":"Katsuhiko Ase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Ase","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103503254","display_name":"Koichi Igarashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Igarashi","raw_affiliation_strings":["Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Laboratories, Central Research Division, Takeda Chemical Industries, Osaka 532, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006534769","display_name":"Yasutomi Nishizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutomi Nishizuka","raw_affiliation_strings":["Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.5161,"has_fulltext":false,"cited_by_count":312,"citation_normalized_percentile":{"value":0.99586156,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"236","issue":"4805","first_page":"1116","last_page":"1120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9850000143051147},{"id":"https://openalex.org/keywords/single-gene","display_name":"single gene","score":0.4560000002384186},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cdna","display_name":"cDNA","score":0.503000020980835},{"id":"https://openalex.org/keywords/c-terminal-region","display_name":"C-terminal region","score":0.765999972820282},{"id":"https://openalex.org/keywords/calcium-response","display_name":"calcium response","score":0.3709999918937683},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6320000290870667},{"id":"https://openalex.org/keywords/genome-structure","display_name":"genome structure","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6868110299110413},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6819884777069092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6002055406570435},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5794580578804016},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.5674135088920593},{"id":"https://openalex.org/C17966761","wikidata":"https://www.wikidata.org/wiki/Q68947","display_name":"Subspecies","level":2,"score":0.552104651927948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468322038650513},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.5265610218048096},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5075949430465698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4879688620567322},{"id":"https://openalex.org/C186518008","wikidata":"https://www.wikidata.org/wiki/Q18030780","display_name":"PRKCQ","level":5,"score":0.45516785979270935},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4399990141391754},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4211716651916504},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.39530402421951294},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3588659167289734},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.30215978622436523},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2777244448661804},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09759858250617981},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.3576226","doi":"https://doi.org/10.1126/science.3576226","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3576226","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3576226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3576226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1483045044","https://openalex.org/W1595486227","https://openalex.org/W1676010976","https://openalex.org/W1918119607","https://openalex.org/W1964839077","https://openalex.org/W1965372133","https://openalex.org/W2001668713","https://openalex.org/W2002468039","https://openalex.org/W2009856702","https://openalex.org/W2011836510","https://openalex.org/W2029987769","https://openalex.org/W2037385247","https://openalex.org/W2054800842","https://openalex.org/W2056382343","https://openalex.org/W2057339816","https://openalex.org/W2060333964","https://openalex.org/W2072436875","https://openalex.org/W2094069133","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2122385641","https://openalex.org/W2138270253","https://openalex.org/W2147731090","https://openalex.org/W2174520807"],"related_works":["https://openalex.org/W1595486227","https://openalex.org/W2074531238","https://openalex.org/W1989231246","https://openalex.org/W2087236026","https://openalex.org/W2088072731","https://openalex.org/W2426793753","https://openalex.org/W225412443","https://openalex.org/W2002468039","https://openalex.org/W3176112233","https://openalex.org/W2090300288"],"abstract_inverted_index":{"Two":[0],"complementary":[1,28],"DNA's,":[2],"encoding":[3],"the":[4,34,51,89,111],"complete":[5],"sequences":[6],"of":[7,15,42,54,63,88,92,110,119,128],"671":[8],"and":[9,44,72,80,83],"673":[10],"amino":[11],"acids":[12],"for":[13],"subspecies":[14,91,118],"rat":[16,99],"brain":[17,100],"protein":[18,64,93,120],"kinase":[19,65,94,121],"C,":[20],"were":[21,84],"expressed":[22],"in":[23,50,98,103],"COS":[24,105],"7":[25,106],"cells.":[26,107],"The":[27,74],"DNA":[29],"sequence":[30],"analysis":[31,109],"predicted":[32],"that":[33,67,96,115],"two":[35,117],"enzymes":[36,59,75],"are":[37],"derived":[38],"from":[39,46,86,125],"different":[40],"ways":[41],"splicing":[43,127],"differ":[45],"each":[47],"other":[48],"only":[49],"short":[52],"ranges":[53],"their":[55],"carboxyl-terminal":[56],"regions.":[57],"Both":[58],"showed":[60,76],"typical":[61],"characteristics":[62],"C":[66,95,122],"responded":[68],"to":[69],"Ca2+,":[70],"phospholipid,":[71],"diacylglycerol.":[73],"practically":[77],"identical":[78],"physical":[79],"kinetic":[81],"properties":[82],"indistinguishable":[85],"one":[87],"several":[90],"occurs":[97],"but":[101],"not":[102],"untransfected":[104],"Partial":[108],"genomic":[112],"structure":[113],"confirmed":[114],"these":[116],"resulted":[123],"indeed":[124],"alternative":[126],"a":[129],"single":[130],"gene.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
