{"id":"https://openalex.org/W2035974682","doi":"https://doi.org/10.1074/jbc.r800073200","title":"Rassf Family of Tumor Suppressor Polypeptides","display_name":"Rassf Family of Tumor Suppressor Polypeptides","publication_year":2008,"publication_date":"2008-12-18","ids":{"openalex":"https://openalex.org/W2035974682","doi":"https://doi.org/10.1074/jbc.r800073200","mag":"2035974682","pmid":"https://pubmed.ncbi.nlm.nih.gov/19091744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2670104"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.r800073200","doi":"https://doi.org/10.1074/jbc.r800073200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800073200","pdf_url":"http://www.jbc.org/article/S0021925820768948/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820768948/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031714701","display_name":"Joseph Avruch","orcid":"https://orcid.org/0000-0003-4940-3495","observed_orcids":["https://orcid.org/0000-0003-4940-3495"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph Avruch","raw_affiliation_strings":["Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. avruch@molbio.mgh.harvard.edu","Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. avruch@molbio.mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056408708","display_name":"Ramnik J. Xavier","orcid":"https://orcid.org/0000-0002-5630-5167","observed_orcids":["https://orcid.org/0000-0002-5630-5167"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramnik Xavier","raw_affiliation_strings":["Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Gastrointestinal Units of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4405271026"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Gastrointestinal Units of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108207076","display_name":"Nabeel M. Bardeesy","orcid":"https://orcid.org/0000-0003-3867-0416","observed_orcids":["https://orcid.org/0000-0003-3867-0416"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabeel Bardeesy","raw_affiliation_strings":["Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693716","display_name":"Xianfeng Zhang","orcid":"https://orcid.org/0000-0003-0944-7151","observed_orcids":["https://orcid.org/0000-0003-0944-7151"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xian-feng Zhang","raw_affiliation_strings":["Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085864440","display_name":"Maria D. Praskova","orcid":"https://orcid.org/0000-0002-8149-9039","observed_orcids":["https://orcid.org/0000-0002-8149-9039"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Praskova","raw_affiliation_strings":["Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085034299","display_name":"Dawang Zhou","orcid":"https://orcid.org/0000-0002-9053-5249","observed_orcids":["https://orcid.org/0000-0002-9053-5249"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawang Zhou","raw_affiliation_strings":["Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080952859","display_name":"Fan Xia","orcid":"https://orcid.org/0000-0002-4013-8173","observed_orcids":["https://orcid.org/0000-0002-4013-8173"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Xia","raw_affiliation_strings":["Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031714701"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.695,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.53666741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"284","issue":"17","first_page":"11001","last_page":"11005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.7279999852180481},{"id":"https://openalex.org/keywords/heterodimerization","display_name":"heterodimerization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ras-like-gtpases","display_name":"Ras-related GTPases","score":0.9089999794960022},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9210000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6507841944694519},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6009576916694641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5987876653671265},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5931485891342163},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5305640697479248},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4600162208080292},{"id":"https://openalex.org/C178628643","wikidata":"https://www.wikidata.org/wiki/Q410233","display_name":"Merlin (protein)","level":4,"score":0.42842021584510803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3559388518333435},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2622101902961731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18922200798988342}],"mesh":[{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.r800073200","doi":"https://doi.org/10.1074/jbc.r800073200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800073200","pdf_url":"http://www.jbc.org/article/S0021925820768948/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1942506","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2670104","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2670104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2670104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19091744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19091744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/41483004","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483004","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.r800073200","doi":"https://doi.org/10.1074/jbc.r800073200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800073200","pdf_url":"http://www.jbc.org/article/S0021925820768948/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1107783668","display_name":"Boston Area Diabetes Endocrinology Research Center","funder_award_id":"P30DK057521","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1589144027","display_name":null,"funder_award_id":"(DK043351","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2943259275","display_name":"Role of Carma1 in Inflammatory Lung Disease","funder_award_id":"R01HL088297","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4462181674","display_name":null,"funder_award_id":"DK-17776","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4946215839","display_name":null,"funder_award_id":"HL-088297","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000890720","display_name":"Training Program in Endocrinology","funder_award_id":"T32DK007028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000895811","display_name":"Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital","funder_award_id":"P30DK043351","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035974682.pdf","grobid_xml":"https://content.openalex.org/works/W2035974682.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1495361973","https://openalex.org/W1504197144","https://openalex.org/W1953337176","https://openalex.org/W1963495112","https://openalex.org/W1968910405","https://openalex.org/W1974673111","https://openalex.org/W1975851778","https://openalex.org/W1976356130","https://openalex.org/W1986406749","https://openalex.org/W1999332777","https://openalex.org/W2016672123","https://openalex.org/W2025453886","https://openalex.org/W2027928327","https://openalex.org/W2032853143","https://openalex.org/W2034059681","https://openalex.org/W2035293726","https://openalex.org/W2036243096","https://openalex.org/W2041889626","https://openalex.org/W2050474151","https://openalex.org/W2052333525","https://openalex.org/W2055523552","https://openalex.org/W2059440739","https://openalex.org/W2066118482","https://openalex.org/W2067942051","https://openalex.org/W2077962784","https://openalex.org/W2093223139","https://openalex.org/W2094632474","https://openalex.org/W2095218305","https://openalex.org/W2097125793","https://openalex.org/W2097192405","https://openalex.org/W2106826824","https://openalex.org/W2107168679","https://openalex.org/W2107866321","https://openalex.org/W2139526606","https://openalex.org/W2147046167","https://openalex.org/W2158150128","https://openalex.org/W2159165758","https://openalex.org/W2160232849","https://openalex.org/W2163171275","https://openalex.org/W2165639753","https://openalex.org/W3017591832"],"related_works":["https://openalex.org/W7099070858","https://openalex.org/W2332464391","https://openalex.org/W7042899534","https://openalex.org/W2598384485","https://openalex.org/W7098801272","https://openalex.org/W2191616177","https://openalex.org/W2031449303","https://openalex.org/W603747999","https://openalex.org/W2044465934","https://openalex.org/W1533028780"],"abstract_inverted_index":{"The":[0,24],"Rassf1-6":[1],"polypeptides":[2,84],"each":[3],"contain":[4],"a":[5,45],"Ras/Rap":[6,25],"association":[7,26],"domain,":[8],"which":[9,33],"enables":[10],"binding":[11,80],"to":[12,85],"several":[13],"GTP-charged":[14],"Ras-like":[15,86],"GTPases,":[16],"at":[17],"least":[18],"in":[19,61,72,95],"vitro":[20],"or":[21],"when":[22,70],"overexpressed.":[23],"domains":[27],"are":[28],"followed":[29],"by":[30],"SARAH":[31],"domains,":[32],"mediate":[34],"Rassf":[35,50,83,96],"heterodimerization":[36],"with":[37],"the":[38,79,82,89],"Mst1/2":[39,90],"protein":[40],"kinases.":[41],"Rassf1A":[42],"is":[43],"unequivocally":[44],"tumor":[46,54,73],"suppressor,":[47],"and":[48,65,88,92],"all":[49],"proteins":[51],"behave":[52],"like":[53],"suppressors,":[55],"exhibiting":[56],"epigenetic":[57],"silencing":[58],"of":[59,81],"expression":[60],"many":[62],"human":[63],"cancers":[64],"pro-apoptotic":[66],"and/or":[67],"anti-proliferative":[68],"effects":[69],"re-expressed":[71],"cell":[74],"lines.":[75],"Herein,":[76],"we":[77],"review":[78],"GTPases":[87],"kinases":[91],"their":[93],"role":[94],"function.":[97]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
