{"id":"https://openalex.org/W2035967441","doi":"https://doi.org/10.1016/j.pain.2011.04.015","title":"Antinociceptive effect of Brazilian armed spider venom toxin Tx3\u20133 in animal models of neuropathic pain","display_name":"Antinociceptive effect of Brazilian armed spider venom toxin Tx3\u20133 in animal models of neuropathic pain","publication_year":2011,"publication_date":"2011-05-21","ids":{"openalex":"https://openalex.org/W2035967441","doi":"https://doi.org/10.1016/j.pain.2011.04.015","mag":"2035967441","pmid":"https://pubmed.ncbi.nlm.nih.gov/21570770"},"language":"en","primary_location":{"id":"doi:10.1016/j.pain.2011.04.015","doi":"https://doi.org/10.1016/j.pain.2011.04.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2011.04.015","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111592919","display_name":"Gerusa Duarte Dalmolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR","CA"],"is_corresponding":false,"raw_author_name":"Gerusa Duarte Dalmolin","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Robarts Research Institute, University of Western Ontario, London, Ontario, Canada N\u00facleo de P\u00f3s-gradua\u00e7\u00e3o, Santa Casa de Belo Horizonte, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Robarts Research Institute, University of Western Ontario, London, Ontario, Canada N\u00facleo de P\u00f3s-gradua\u00e7\u00e3o, Santa Casa de Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I125749732","https://openalex.org/I33501960"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059518812","display_name":"C\u00e1ssia Regina Silva","orcid":"https://orcid.org/0000-0002-1353-2570","observed_orcids":["https://orcid.org/0000-0002-1353-2570"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C\u00e1ssia Regina Silva","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040273897","display_name":"Fl\u00e1via Karine Rigo","orcid":"https://orcid.org/0000-0003-2976-8841","observed_orcids":["https://orcid.org/0000-0003-2976-8841"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via Karine Rigo","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041885757","display_name":"Guilherme M. Gomes","orcid":"https://orcid.org/0000-0001-8566-4284","observed_orcids":["https://orcid.org/0000-0001-8566-4284"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Monteiro Gomes","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057190304","display_name":"Marta Nascimento Cordeiro","orcid":"https://orcid.org/0009-0000-9102-4742","observed_orcids":["https://orcid.org/0009-0000-9102-4742"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marta do Nascimento Cordeiro","raw_affiliation_strings":["Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056590587","display_name":"Michael Richardson","orcid":"https://orcid.org/0000-0002-3797-6408","observed_orcids":["https://orcid.org/0000-0002-3797-6408"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Michael Richardson","raw_affiliation_strings":["Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082202542","display_name":"Marco Aur\u00e9lio Romano\u2010Silva","orcid":"https://orcid.org/0000-0002-6558-4639","observed_orcids":["https://orcid.org/0000-0002-6558-4639"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marco Aur\u00e9lio Romano Silva","raw_affiliation_strings":["Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044236118","display_name":"Marco A. M. Prado","orcid":"https://orcid.org/0000-0002-3028-5778","observed_orcids":["https://orcid.org/0000-0002-3028-5778"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["BR","CA"],"is_corresponding":false,"raw_author_name":"Marco Antonio M\u00e1ximo Prado","raw_affiliation_strings":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","Robarts Research Institute, University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Robarts Research Institute, University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028052126","display_name":"Marcus V. Gomez","orcid":"https://orcid.org/0000-0002-6082-930X","observed_orcids":["https://orcid.org/0000-0002-6082-930X"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210123796","display_name":"Grupo Santa Casa de Belo Horizonte","ror":"https://ror.org/024w2fr05","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210123796"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcus Vinicius Gomez","raw_affiliation_strings":["Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","N\u00facleo de P\u00f3s-gradua\u00e7\u00e3o, Santa Casa de Belo Horizonte, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Neuroci\u00eancia, Departamento de Sa\u00fade Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"N\u00facleo de P\u00f3s-gradua\u00e7\u00e3o, Santa Casa de Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210123796"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056242920","display_name":"Juliano Ferreira","orcid":"https://orcid.org/0000-0002-9562-0602","observed_orcids":["https://orcid.org/0000-0002-9562-0602"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Juliano Ferreira","raw_affiliation_strings":["Corresponding author at: Department of Chemistry, Universidade Federal de Santa Maria, Avenida Roraima n\u00b0 1000 Bairro Camobi, Santa Maria, RS, Brazil. Tel.: +55 55 32208053; fax: +55 55 32208031","Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil","Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","fax: +55 55 32208031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author at: Department of Chemistry, Universidade Federal de Santa Maria, Avenida Roraima n\u00b0 1000 Bairro Camobi, Santa Maria, RS, Brazil. Tel.: +55 55 32208053; fax: +55 55 32208031","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Toxicol\u00f3gica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Farmacologia Bioqu\u00edmica e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"fax: +55 55 32208031","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5056242920"],"corresponding_institution_ids":["https://openalex.org/I110200422","https://openalex.org/I33501960"],"apc_list":null,"apc_paid":null,"fwci":4.3382,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.94111175,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"152","issue":"10","first_page":"2224","last_page":"2232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spider-venom-peptides","display_name":"spider venom peptides","score":0.5680000185966492},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/sciatic-nerve-ligation","display_name":"sciatic nerve ligation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.8429999947547913},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.828000009059906},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.6899999976158142},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/omega-conotoxin-mviic","display_name":"omega-conotoxin MVIIC","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8293171525001526},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.8148671984672546},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.7260200381278992},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.6730993390083313},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6364036202430725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6075794696807861},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.5485610961914062},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5262987613677979},{"id":"https://openalex.org/C52396799","wikidata":"https://www.wikidata.org/wiki/Q7676069","display_name":"Tail flick test","level":4,"score":0.5115864872932434},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5023696422576904},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.4190966784954071},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.41115081310272217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24441936612129211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21383199095726013},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19285520911216736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1784900426864624},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.12428757548332214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013111","descriptor_name":"Spider Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pain.2011.04.015","doi":"https://doi.org/10.1016/j.pain.2011.04.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2011.04.015","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:21570770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21570770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W7946861","https://openalex.org/W127587495","https://openalex.org/W261751048","https://openalex.org/W1484197568","https://openalex.org/W1526580466","https://openalex.org/W1733175287","https://openalex.org/W1914090025","https://openalex.org/W1965066118","https://openalex.org/W1965285506","https://openalex.org/W1965466577","https://openalex.org/W1966951820","https://openalex.org/W1969040773","https://openalex.org/W1975585602","https://openalex.org/W1975744071","https://openalex.org/W1978845898","https://openalex.org/W1981152439","https://openalex.org/W1983407790","https://openalex.org/W1990693103","https://openalex.org/W1991550485","https://openalex.org/W1992432492","https://openalex.org/W1995047376","https://openalex.org/W1999893599","https://openalex.org/W2004219505","https://openalex.org/W2005040986","https://openalex.org/W2018021139","https://openalex.org/W2018459912","https://openalex.org/W2018931883","https://openalex.org/W2020528439","https://openalex.org/W2024124332","https://openalex.org/W2026905490","https://openalex.org/W2032529224","https://openalex.org/W2034102455","https://openalex.org/W2035428388","https://openalex.org/W2036125867","https://openalex.org/W2037812600","https://openalex.org/W2038223161","https://openalex.org/W2040152683","https://openalex.org/W2046194656","https://openalex.org/W2048355813","https://openalex.org/W2048793794","https://openalex.org/W2048890215","https://openalex.org/W2051057606","https://openalex.org/W2053855385","https://openalex.org/W2056829170","https://openalex.org/W2060533392","https://openalex.org/W2063361485","https://openalex.org/W2063983467","https://openalex.org/W2066187637","https://openalex.org/W2066707647","https://openalex.org/W2069675298","https://openalex.org/W2070311218","https://openalex.org/W2075046805","https://openalex.org/W2078195259","https://openalex.org/W2083014566","https://openalex.org/W2083375671","https://openalex.org/W2083666271","https://openalex.org/W2087454739","https://openalex.org/W2087728216","https://openalex.org/W2089176402","https://openalex.org/W2089633836","https://openalex.org/W2092812834","https://openalex.org/W2092902672","https://openalex.org/W2094310013","https://openalex.org/W2100178054","https://openalex.org/W2116411564","https://openalex.org/W2117954460","https://openalex.org/W2124431153","https://openalex.org/W2133387156","https://openalex.org/W2138512124","https://openalex.org/W2141005071","https://openalex.org/W2141660954","https://openalex.org/W2143416389","https://openalex.org/W2149674899","https://openalex.org/W2151024126","https://openalex.org/W2152791101","https://openalex.org/W2155452679","https://openalex.org/W2165328940","https://openalex.org/W2170787296","https://openalex.org/W2172201406","https://openalex.org/W2206043426","https://openalex.org/W2217238653","https://openalex.org/W2241390671","https://openalex.org/W2786775915","https://openalex.org/W4300007302"],"related_works":["https://openalex.org/W2972856708","https://openalex.org/W2277586129","https://openalex.org/W1823875276","https://openalex.org/W2020349444","https://openalex.org/W2730311787","https://openalex.org/W2981833607","https://openalex.org/W2336147768","https://openalex.org/W3033100558","https://openalex.org/W1995857153","https://openalex.org/W2340402612"],"abstract_inverted_index":{"Venoms":[0],"peptides":[1],"have":[2],"produced":[3,173],"exceptional":[4],"sources":[5],"for":[6,103,239],"drug":[7],"development":[8],"to":[9,146],"treat":[10],"pain.":[11,71,199,244],"In":[12,72],"this":[13,229],"study":[14],"we":[15],"examined":[16],"the":[17,45,73,121,188,212,240],"antinociceptive":[18,157,209,224],"and":[19,40,61,65,79,92,99,105,130,180,185,216,253],"side":[20],"effects":[21,46,210,222],"of":[22,47,52,83,96,165,193,242],"Tx3-3,":[23,249],"a":[24,88,128,155,235,250],"peptide":[25,230],"toxin":[26,231],"isolated":[27],"from":[28,135],"Phoneutria":[29],"nigriventer":[30],"venom,":[31,138],"which":[32],"inhibits":[33],"high-voltage-dependent":[34],"calcium":[35,255],"channels":[36],"(VDCC),":[37],"preferentially":[38],"P/Q":[39,129,252],"R-type":[41,254],"VDCC.":[42],"We":[43],"tested":[44],"Tx3-3":[48,84,153,166,194,206],"in":[49,85,149,159,178,183,211,261],"animal":[50,262],"models":[51,215],"nociceptive":[53],"(tail-flick":[54],"test),":[55],"neuropathic":[56,160,213,243,263],"(partial":[57],"sciatic":[58,175],"nerve":[59,176],"ligation":[60],"streptozotocin-induced":[62,181],"diabetic":[63],"neuropathy),":[64],"inflammatory":[66,198],"(intraplantar":[67],"complete":[68],"Freund's":[69],"adjuvant)":[70],"tail-flick":[74],"test,":[75],"both":[76,170],"intrathecal":[77],"(i.t.)":[78],"intracerebroventricular":[80],"(i.c.v.)":[81],"injection":[82,164,192],"mice":[86,179,184],"caused":[87,139],"short-lasting":[89],"effect":[90,158],"(ED(50)":[91],"95%":[93],"confidence":[94],"intervals":[95],"8.8":[97],"[4.1-18.8]":[98],"3.7":[100],"[1.6-8.4]":[101],"pmol/site":[102],"i.t.":[104,191],"i.c.v.":[106],"injection,":[107],"respectively),":[108],"without":[109],"impairing":[110],"motor":[111,141,221],"functions,":[112],"at":[113,115,143,223],"least":[114],"doses":[116,144],"10-30":[117],"times":[118],"higher":[119],"than":[120],"effective":[122],"dose.":[123],"By":[124],"comparison,":[125],"\u03c9-conotoxin":[126],"MVIIC,":[127],"N-type":[131],"VDCC":[132],"blocker":[133],"derived":[134],"Conus":[136],"magus":[137],"significant":[140],"impairment":[142],"close":[145],"efficacious":[147,225],"dose":[148],"tail":[150],"flick":[151],"test.":[152],"showed":[154],"long-lasting":[156],"pain":[161,214,264],"models.":[162,265],"Intrathecal":[163],"(30":[167],"pmol/site)":[168],"decreased":[169],"mechanical":[171],"allodynia":[172,182,260],"by":[174],"injury":[177],"rats.":[186],"On":[187],"other":[189],"hand,":[190],"did":[195],"not":[196,218],"alter":[197],"Taken":[200],"together,":[201],"our":[202],"data":[203],"show":[204],"that":[205,228],"shows":[207],"prevalent":[208],"does":[217],"cause":[219],"adverse":[220],"doses,":[226],"suggesting":[227],"holds":[232],"promise":[233],"as":[234],"novel":[236],"therapeutic":[237],"agent":[238],"control":[241],"The":[245],"Brazilian":[246],"armed":[247],"spider":[248],"new":[251],"channel":[256],"blocker,":[257],"effectively":[258],"alleviates":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}