{"id":"https://openalex.org/W2035909252","doi":"https://doi.org/10.1074/jbc.m500437200","title":"Identification of Direct Genomic Targets Downstream of the Nuclear Factor-\u03baB Transcription Factor Mediating Tumor Necrosis Factor Signaling","display_name":"Identification of Direct Genomic Targets Downstream of the Nuclear Factor-\u03baB Transcription Factor Mediating Tumor Necrosis Factor Signaling","publication_year":2005,"publication_date":"2005-02-21","ids":{"openalex":"https://openalex.org/W2035909252","doi":"https://doi.org/10.1074/jbc.m500437200","mag":"2035909252","pmid":"https://pubmed.ncbi.nlm.nih.gov/15722553"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m500437200","doi":"https://doi.org/10.1074/jbc.m500437200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500437200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m500437200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023142406","display_name":"Bing Tian","orcid":"https://orcid.org/0000-0002-5497-1158","observed_orcids":["https://orcid.org/0000-0002-5497-1158"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Tian","raw_affiliation_strings":["Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555-1060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Texas Medical Branch, Galveston, Texas 77555-1060, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076807897","display_name":"David E. Nowak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Nowak","raw_affiliation_strings":["Department of Medicine and the","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the","institution_ids":[]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103980549","display_name":"Mohammad Jamaluddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Jamaluddin","raw_affiliation_strings":["Department of Medicine and the","Institute for Translational Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the","institution_ids":[]},{"raw_affiliation_string":"Institute for Translational Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932393","display_name":"Shaofei Wang","orcid":"https://orcid.org/0000-0002-8408-3151","observed_orcids":["https://orcid.org/0000-0002-8408-3151"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaofei Wang","raw_affiliation_strings":["Department of Medicine and the","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the","institution_ids":[]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056656832","display_name":"Allan R. Brasier","orcid":"https://orcid.org/0000-0002-5012-4090","observed_orcids":["https://orcid.org/0000-0002-5012-4090"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan R. Brasier","raw_affiliation_strings":["Department of Medicine and the","Sealy Center for Molecular Science, The University of Texas Medical Branch, Galveston, Texas 77555-1060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the","institution_ids":[]},{"raw_affiliation_string":"Sealy Center for Molecular Science, The University of Texas Medical Branch, Galveston, Texas 77555-1060","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056656832"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.617,"has_fulltext":false,"cited_by_count":233,"citation_normalized_percentile":{"value":0.97891695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"280","issue":"17","first_page":"17435","last_page":"17448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9449999928474426},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.6200000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.7039999961853027},{"id":"https://openalex.org/keywords/ikappabepsilon","display_name":"I\u03baB\u03b5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd127","display_name":"CD127","score":0.8859999775886536},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.718999981880188},{"id":"https://openalex.org/keywords/promoter-binding-sites","display_name":"promoter binding sites","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7810547947883606},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5776479840278625},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.5502923130989075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48734912276268005},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.47298774123191833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44476187229156494},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4423518180847168},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35116153955459595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2866889238357544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19436511397361755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1172107458114624},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06342244148254395},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m500437200","doi":"https://doi.org/10.1074/jbc.m500437200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500437200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15722553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15722553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m500437200","doi":"https://doi.org/10.1074/jbc.m500437200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500437200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G131960621","display_name":"Cellular Response Mechanisms to Environmental Challenge","funder_award_id":"P30ES006676","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6184979407","display_name":"REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION","funder_award_id":"R01AI040218","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W29703230","https://openalex.org/W140601849","https://openalex.org/W200840085","https://openalex.org/W216362062","https://openalex.org/W1480466711","https://openalex.org/W1498410508","https://openalex.org/W1507213876","https://openalex.org/W1574813722","https://openalex.org/W1596801838","https://openalex.org/W1621649724","https://openalex.org/W1763097477","https://openalex.org/W1825540737","https://openalex.org/W1840693165","https://openalex.org/W1962468650","https://openalex.org/W1971044323","https://openalex.org/W1974162725","https://openalex.org/W1974988460","https://openalex.org/W1982062664","https://openalex.org/W1982160526","https://openalex.org/W1982528660","https://openalex.org/W1987097007","https://openalex.org/W1993936200","https://openalex.org/W1994144799","https://openalex.org/W1994888948","https://openalex.org/W1995747121","https://openalex.org/W1997048360","https://openalex.org/W2002507218","https://openalex.org/W2002708977","https://openalex.org/W2007986629","https://openalex.org/W2016909880","https://openalex.org/W2018554367","https://openalex.org/W2029276835","https://openalex.org/W2029441111","https://openalex.org/W2032514624","https://openalex.org/W2036528355","https://openalex.org/W2038890616","https://openalex.org/W2045714098","https://openalex.org/W2051831012","https://openalex.org/W2057093252","https://openalex.org/W2061300591","https://openalex.org/W2064258789","https://openalex.org/W2065022495","https://openalex.org/W2065257477","https://openalex.org/W2072584274","https://openalex.org/W2073296110","https://openalex.org/W2077468629","https://openalex.org/W2078095350","https://openalex.org/W2080914889","https://openalex.org/W2083846843","https://openalex.org/W2088469845","https://openalex.org/W2089394364","https://openalex.org/W2090429649","https://openalex.org/W2104889630","https://openalex.org/W2106491281","https://openalex.org/W2110307590","https://openalex.org/W2117828340","https://openalex.org/W2124808885","https://openalex.org/W2131727513","https://openalex.org/W2132877097","https://openalex.org/W2133694559","https://openalex.org/W2133982451","https://openalex.org/W2134735073","https://openalex.org/W2140277400","https://openalex.org/W2142541950","https://openalex.org/W2142890842","https://openalex.org/W2144413274","https://openalex.org/W2149769193","https://openalex.org/W2159833023","https://openalex.org/W2160272188","https://openalex.org/W2166781237","https://openalex.org/W2317184793","https://openalex.org/W2331176038","https://openalex.org/W2999065750","https://openalex.org/W4300503127","https://openalex.org/W4313333721"],"related_works":["https://openalex.org/W2134558816","https://openalex.org/W2016909880","https://openalex.org/W7098332767","https://openalex.org/W2028189849","https://openalex.org/W2412435172","https://openalex.org/W2116094765","https://openalex.org/W2059878047","https://openalex.org/W2019642531","https://openalex.org/W4246879389","https://openalex.org/W2331375418"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor":[2],"(TNF)":[3],"is":[4,21,34],"a":[5,41,60,89],"pro-inflammatory":[6],"cytokine":[7],"that":[8,81],"controls":[9],"expression":[10],"of":[11,31,63,71,114,148,166,179,232,238],"inflammatory":[12],"genetic":[13],"networks.":[14],"Although":[15],"the":[16,28,67,164,177,207,226],"nuclear":[17],"factor-kappaB":[18],"(NF-kappaB)":[19],"pathway":[20],"crucial":[22],"for":[23],"mediating":[24],"cellular":[25,108],"TNF":[26,64,85,167,170,233],"responses,":[27],"complete":[29],"spectrum":[30],"NF-kappaB-dependent":[32,52,117,127,228],"genes":[33,80,118,121,175,189],"unknown.":[35],"In":[36],"this":[37,243],"study,":[38],"we":[39],"used":[40,136],"tetracycline-regulated":[42],"cell":[43],"line":[44],"expressing":[45],"an":[46],"NF-kappaB":[47,72,145,185],"inhibitor":[48],"to":[49,96,125,137],"systematically":[50,224],"identify":[51,225],"genes.":[53],"A":[54,154,217],"microarray":[55],"data":[56],"set":[57],"generated":[58],"from":[59],"time":[61],"course":[62],"stimulation":[65],"in":[66,91,106,163,176,187,218],"presence":[68],"or":[69,143],"absence":[70,165,178],"signaling":[73],"was":[74],"analyzed.":[75],"We":[76],"identified":[77],"50":[78],"unique":[79],"were":[82,101,135,141,190],"regulated":[83,241],"by":[84,192,198,242],"(Pr(F)<0.001)":[86],"and":[87,119,133,161,196,211],"demonstrated":[88],"change":[90],"signal":[92],"intensity":[93],"of+/-3-fold":[94],"relative":[95],"control.":[97],"Of":[98],"these,":[99],"28":[100],"NF-kappaB-dependent,":[102],"encoding":[103],"proteins":[104],"involved":[105],"diverse":[107],"activities.":[109],"Quantitative":[110],"real-time":[111],"PCR":[112],"assays":[113,205],"eight":[115],"characterized":[116],"five":[120],"not":[122],"previously":[123],"known":[124],"be":[126],"(Gro-beta":[128],"and-gamma,":[129],"IkappaBepsilon,":[130],"interleukin":[131],"(IL)-7R,":[132],"Naf-1)":[134],"determine":[138],"whether":[139],"they":[140],"directly":[142,214],"indirectly":[144],"regulated.":[146],"Expression":[147],"constitutively":[149],"active":[150],"enhanced":[151],"green":[152],"fluorescent.NF-kappaB/Rel":[153],"fusion":[155],"protein":[156,181],"transactivated":[157],"all":[158,173],"but":[159],"IL-6":[160],"IL-7R":[162],"stimulation.":[168],"Moreover,":[169],"strongly":[171],"induced":[172],"12":[174],"new":[180],"synthesis.":[182],"High":[183],"probability":[184],"sites":[186],"novel":[188],"predicted":[191],"binding":[193],"site":[194],"analysis":[195],"confirmed":[197],"electrophoretic":[199],"mobility":[200],"shift":[201],"assay.":[202],"Chromatin":[203],"immunoprecipitation":[204],"show":[206],"endogenous":[208],"IkappaBalpha/epsilon,":[209],"Gro-beta/gamma,":[210],"Naf-1":[212],"promoters":[213],"bound":[215],"NF-kappaB/Rel":[216],"TNF-stimulated":[219],"cells.":[220],"Together,":[221],"these":[222],"studies":[223],"direct":[227],"gene":[229],"network":[230],"downstream":[231],"signaling,":[234],"extending":[235],"our":[236],"knowledge":[237],"biological":[239],"processes":[240],"pathway.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}