{"id":"https://openalex.org/W2035908704","doi":"https://doi.org/10.1002/cncr.20977","title":"A Phase I clinical trial of ixabepilone (BMS\u2010247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days","display_name":"A Phase I clinical trial of ixabepilone (BMS\u2010247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days","publication_year":2005,"publication_date":"2005-03-30","ids":{"openalex":"https://openalex.org/W2035908704","doi":"https://doi.org/10.1002/cncr.20977","mag":"2035908704","pmid":"https://pubmed.ncbi.nlm.nih.gov/15800893"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.20977","doi":"https://doi.org/10.1002/cncr.20977","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.20977","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.20977","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.20977","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109940539","display_name":"Sen Hong Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sen H. Zhuang","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA","Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","The order of the first two authors is arbitrary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"The order of the first two authors is arbitrary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083533154","display_name":"Manish Agrawal","orcid":"https://orcid.org/0000-0001-8208-0582","observed_orcids":["https://orcid.org/0000-0001-8208-0582"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish Agrawal","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","The order of the first two authors is arbitrary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"The order of the first two authors is arbitrary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008898573","display_name":"Maureen Edgerly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen Edgerly","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041536021","display_name":"Susan Bakke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Bakke","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110266399","display_name":"Herbert L. Kotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herb Kotz","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026954192","display_name":"Paul M. Thambi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thambi","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047567802","display_name":"Ann Rutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Rutt","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank M. Balis","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Bates","raw_affiliation_strings":["Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006092876","display_name":"Tito Fojo","orcid":"https://orcid.org/0000-0002-8083-2688","observed_orcids":["https://orcid.org/0000-0002-8083-2688","https://orcid.org/0000-0001-9209-8831"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tito Fojo","raw_affiliation_strings":["","Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Cancer Therapeutics Branch, Center of Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006092876"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":7.1501,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.97893961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"103","issue":"9","first_page":"1932","last_page":"1938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ixabepilone","display_name":"ixabepilone","score":1.0},{"id":"https://openalex.org/keywords/epothilone-b-analog","display_name":"epothilone B analog","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microtubule-stabilizing-agents","display_name":"microtubule-stabilizing agents","score":0.9679999947547913},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.996999979019165},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mesothelioma","display_name":"mesothelioma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimitotic-chemotherapy","display_name":"antimitotic chemotherapy","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.90373694896698},{"id":"https://openalex.org/C2779194965","wikidata":"https://www.wikidata.org/wiki/Q11711607","display_name":"Ixabepilone","level":5,"score":0.8825191259384155},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5542082190513611},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.48121073842048645},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.4410628378391266},{"id":"https://openalex.org/C2777526313","wikidata":"https://www.wikidata.org/wiki/Q408201","display_name":"Epothilone","level":2,"score":0.41867882013320923},{"id":"https://openalex.org/C2776703092","wikidata":"https://www.wikidata.org/wiki/Q824292","display_name":"Hyponatremia","level":2,"score":0.4131050705909729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4127030670642853},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3839570879936218},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.37900078296661377},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37547633051872253},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3710494041442871},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10379782319068909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034261","descriptor_name":"Epothilones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.20977","doi":"https://doi.org/10.1002/cncr.20977","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.20977","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.20977","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:15800893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15800893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/cncr.20977","doi":"https://doi.org/10.1002/cncr.20977","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.20977","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.20977","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035908704.pdf","grobid_xml":"https://content.openalex.org/works/W2035908704.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1978937316","https://openalex.org/W1979721718","https://openalex.org/W1984050613","https://openalex.org/W1997124626","https://openalex.org/W2012681221","https://openalex.org/W2039589572","https://openalex.org/W2099243119","https://openalex.org/W2109589295","https://openalex.org/W2133243551","https://openalex.org/W2139248078","https://openalex.org/W2146861790","https://openalex.org/W2147051864","https://openalex.org/W2156056306","https://openalex.org/W2157958132","https://openalex.org/W2158749015","https://openalex.org/W2275560127","https://openalex.org/W2287104963","https://openalex.org/W2305150216","https://openalex.org/W2417830187","https://openalex.org/W2597376008","https://openalex.org/W2604765104","https://openalex.org/W2604977540","https://openalex.org/W2620176919","https://openalex.org/W2951673895"],"related_works":["https://openalex.org/W2062399327","https://openalex.org/W2228067035","https://openalex.org/W177209949","https://openalex.org/W2342241463","https://openalex.org/W2165708803","https://openalex.org/W2076811098","https://openalex.org/W2145042104","https://openalex.org/W2253499206","https://openalex.org/W2022138045","https://openalex.org/W2012681221"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,24,83,107,154],"epothilones":[2],"are":[3],"a":[4,15,27,37,58,95],"novel":[5],"class":[6],"of":[7,18,61,91,159,185],"microtubule-stabilizing":[8],"agents.":[9],"Ixabepilone":[10],"(BMS-247550;":[11],"NSC":[12],"710428)":[13],"is":[14],"semisynthetic":[16],"analog":[17],"the":[19,162,175],"natural":[20],"product":[21],"epothilone":[22],"B.":[23],"authors":[25],"conducted":[26],"Phase":[28,156],"I":[29],"study":[30],"by":[31],"administering":[32],"ixabepilone":[33,56,92,160],"to":[34,80],"patients":[35,51,144],"as":[36,94],"1-hour":[38,96],"intravenous":[39,97],"infusion":[40,98],"daily":[41,99,163],"for":[42,68,100,165],"3":[43,69,101,116,166],"consecutive":[44,70,102],"days":[45,103,167],"every":[46,104],"21":[47,105],"days.":[48,71,106],"METHODS:":[49],"Twenty-six":[50],"were":[52,78],"enrolled":[53],"and":[54,75,134,149,187],"received":[55],"at":[57],"starting":[59],"dose":[60,85,158,190],"8":[62,87],"or":[63],"10":[64],"mg/m(2)":[65,88,170],"per":[66,89,171],"day":[67,90],"RESULTS:":[72],"One":[73],"hundred":[74],"nineteen":[76],"cycles":[77,184],"administered":[79,93],"26":[81],"patients.":[82],"maximum-tolerated":[84],"was":[86,111,141,168,174,179,188],"dose-limiting":[108],"toxicity":[109],"(DLT)":[110],"neutropenia.":[112],"Other":[113],"nonhematologic":[114],"Grade":[115],"toxicities":[117],"included":[118],"fatigue":[119],"(3":[120],"cycles),":[121],"hyponatremia":[122],"(1":[123,126,129,132,136],"cycle),":[124,127,130,133],"anorexia":[125],"ileus":[128],"stomatitis":[131],"emesis":[135],"cycle).":[137],"Prolonged":[138],"disease":[139],"stabilization":[140],"observed":[142],"in":[143],"with":[145],"mesothelioma,":[146],"ovarian":[147],"carcinoma,":[148],"renal":[150],"cell":[151],"carcinoma.":[152],"CONCLUSIONS:":[153],"recommended":[155],"II":[157],"on":[161],"schedule":[164],"8-10":[169],"day.":[172],"Neutropenia":[173],"DLT.":[176],"Peripheral":[177],"neuropathy":[178],"mild,":[180],"even":[181],"after":[182],"multiple":[183],"therapy,":[186],"not":[189],"limiting.":[191]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
