{"id":"https://openalex.org/W2035874058","doi":"https://doi.org/10.1055/s-2007-968247","title":"Hydroxylation of Oxindoles and \u03b2-Keto Esters Using DBFOX Ligand","display_name":"Hydroxylation of Oxindoles and \u03b2-Keto Esters Using DBFOX Ligand","publication_year":2007,"publication_date":"2007-02-20","ids":{"openalex":"https://openalex.org/W2035874058","doi":"https://doi.org/10.1055/s-2007-968247","mag":"2035874058"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-968247","doi":"https://doi.org/10.1055/s-2007-968247","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-968247","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077654635","display_name":"Norio Shibata","orcid":"https://orcid.org/0000-0002-3742-4064","observed_orcids":["https://orcid.org/0000-0002-3742-4064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Shibata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T. Toru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Toru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T. Ishimaru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Ishimaru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102900260","display_name":"Jun Nagai","orcid":"https://orcid.org/0000-0003-4720-5065","observed_orcids":["https://orcid.org/0000-0003-4720-5065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Nagai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S. Nakamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004068447","display_name":"Shuji Kanemasa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Kanemasa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2007","issue":"3","first_page":"0294","last_page":"0294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.06650000065565109,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/oxindoles","display_name":"oxindoles","score":0.8690000176429749},{"id":"https://openalex.org/keywords/beta-keto-esters","display_name":"\u03b2-keto esters","score":0.9879999756813049},{"id":"https://openalex.org/keywords/asymmetric-oxidation","display_name":"asymmetric oxidation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nickel-ii-catalysts","display_name":"nickel(II) catalysts","score":0.996999979019165},{"id":"https://openalex.org/keywords/3-hydroxy-2-oxindoles","display_name":"3-hydroxy-2-oxindoles","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9575982093811035},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.8590309619903564},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.8358839750289917},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.718821108341217},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.7117096185684204},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6604136824607849},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6145114898681641},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.46101653575897217},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.410126268863678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.056021809577941895},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.054485321044921875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-968247","doi":"https://doi.org/10.1055/s-2007-968247","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-968247","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070608396","https://openalex.org/W2950245865","https://openalex.org/W2072274972","https://openalex.org/W1987145924","https://openalex.org/W2145862116","https://openalex.org/W2320477420","https://openalex.org/W2950301095","https://openalex.org/W2049026911","https://openalex.org/W2950753042","https://openalex.org/W2334251165"],"abstract_inverted_index":{"Significance":[0],"The":[1],"enantioselective":[2],"synthesis":[3],"of":[4,44,55],"3-aryl-":[5],"and":[6],"3-alkyl-3-hydroxy-2-oxindoles":[7],"is":[8],"described.":[9],"Oxidation":[10],"with":[11,40,48],"the":[12,17,28,33,52],"racemic":[13],"oxidant":[14],"1":[15],"gave":[16,27,36],"best":[18],"results":[19],"when":[20],"employing":[21],"Zn(II)-\u00adDBFOX":[22],"as":[23],"catalyst.":[24],"3-Aryl-substituted":[25],"2-oxindoles":[26],"highest":[29],"ee":[30,37],"values,":[31],"while":[32],"3-alkyl":[34],"derivates":[35],"values":[38],">80%":[39],"reasonable":[41],"yields.":[42],"Use":[43],"this":[45],"oxidation":[46,54],"system":[47],"Ni(II)-DBFOX":[49],"succeeded":[50],"in":[51],"asymmetric":[53],"\u03b2-keto":[56],"esters.":[57]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}