{"id":"https://openalex.org/W2035848683","doi":"https://doi.org/10.1097/ftd.0b013e318228195f","title":"Nonsteroidal Anti-Inflammatory Drugs May Reduce Enterohepatic Recirculation of Mycophenolic Acid in Patients With Childhood-Onset Systemic Lupus Erythematosus","display_name":"Nonsteroidal Anti-Inflammatory Drugs May Reduce Enterohepatic Recirculation of Mycophenolic Acid in Patients With Childhood-Onset Systemic Lupus Erythematosus","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2035848683","doi":"https://doi.org/10.1097/ftd.0b013e318228195f","mag":"2035848683","pmid":"https://pubmed.ncbi.nlm.nih.gov/21860343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090025"},"language":"en","primary_location":{"id":"doi:10.1097/ftd.0b013e318228195f","doi":"https://doi.org/10.1097/ftd.0b013e318228195f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0b013e318228195f","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013881333","display_name":"Tsuyoshi Fukuda","orcid":"https://orcid.org/0000-0002-0477-3102","observed_orcids":["https://orcid.org/0000-0002-0477-3102"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tsuyoshi Fukuda","raw_affiliation_strings":["Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. tsuyoshi.fukuda@cchmc.org","Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, \u2020Department of Pediatrics, University of Cincinnati College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. tsuyoshi.fukuda@cchmc.org","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, \u2020Department of Pediatrics, University of Cincinnati College of Medicine","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021386589","display_name":"Hermine I. Brunner","orcid":"https://orcid.org/0000-0001-9478-2987","observed_orcids":["https://orcid.org/0000-0001-9478-2987"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hermine I Brunner","raw_affiliation_strings":["Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109524882","display_name":"Anna Carmela P. Sagcal\u2010Gironella","orcid":"https://orcid.org/0000-0003-1424-7621","observed_orcids":["https://orcid.org/0000-0003-1424-7621"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Carmela P Sagcal-Gironella","raw_affiliation_strings":["Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander A Vinks","raw_affiliation_strings":["Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, \u2020Department of Pediatrics, University of Cincinnati College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Pediatric Pharmacology Research Unit, \u2020Department of Pediatrics, University of Cincinnati College of Medicine","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013881333","https://openalex.org/A5040060343"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":1.0109,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75800438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"5","first_page":"658","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pediatric-systemic-lupus-erythematosus","display_name":"pediatric lupus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/drug-transporter-interactions","display_name":"drug-transporter interactions","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.906000018119812},{"id":"https://openalex.org/keywords/bile-secretion","display_name":"bile secretion","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.764250636100769},{"id":"https://openalex.org/C2778033501","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolic acid","level":3,"score":0.7499881386756897},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6109737753868103},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5896095037460327},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5613345503807068},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5025043487548828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5016725063323975},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4914301633834839},{"id":"https://openalex.org/C2909935303","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolate","level":3,"score":0.4841778576374054},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4621122479438782},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45226776599884033},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.4303785562515259},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.41994619369506836},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.12203177809715271},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.06311967968940735},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000089762","descriptor_name":"Multidrug Resistance-Associated Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004764","descriptor_name":"Enterohepatic Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/ftd.0b013e318228195f","doi":"https://doi.org/10.1097/ftd.0b013e318228195f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0b013e318228195f","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:21860343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21860343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3061239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4090025","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ther Drug Monit","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3061239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G311998107","display_name":"Optimizing MMF therapy in pediatric transplant patients","funder_award_id":"K24HD050387","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7001105845","display_name":null,"funder_award_id":"P60-AR-047884","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7793709008","display_name":"CHMCC Pediatric Pharmacology Research Unit","funder_award_id":"U10HD037249","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1971387671","https://openalex.org/W2016100084","https://openalex.org/W2020927791","https://openalex.org/W2033304584","https://openalex.org/W2038909026","https://openalex.org/W2048189244","https://openalex.org/W2059681951","https://openalex.org/W2101417364","https://openalex.org/W2129566658","https://openalex.org/W2154582522"],"related_works":["https://openalex.org/W1588816088","https://openalex.org/W2944845384","https://openalex.org/W2154582522","https://openalex.org/W2075825604","https://openalex.org/W4309180694","https://openalex.org/W4396832534","https://openalex.org/W4280603267","https://openalex.org/W2624675005","https://openalex.org/W2952737233","https://openalex.org/W2082930092"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,27],"large":[2,18],"interindividual":[3],"differences":[4],"observed":[5],"in":[6,13,20,79,180,198,224],"mycophenolic":[7],"acid":[8],"(MPA)":[9],"pharmacokinetics":[10],"(MPA-PK)":[11],"are":[12,259],"part":[14,201],"attributed":[15],"to":[16,55,153,261],"the":[17,25,38,41,57,70,126,136,155,199,217,225,237,249],"variability":[19],"enterohepatic":[21],"recirculation":[22],"(EHC)":[23],"of":[24,30,72,82,157,165,178,193,202,240,245,251,254],"drug.":[26],"main":[28],"metabolite":[29],"MPA,":[31],"MPA":[32,97,195,246],"glucuronide":[33],"is":[34],"actively":[35],"secreted":[36],"into":[37],"bile":[39],"via":[40],"multidrug":[42],"resistance-associated":[43],"protein":[44],"2":[45],"(MRP2)":[46],"transporter.":[47],"Nonsteroidal":[48],"anti-inflammatory":[49],"drugs":[50],"(NSAIDs)":[51],"have":[52],"been":[53],"shown":[54],"inhibit":[56],"MRP2":[58,252],"transporter,":[59],"which":[60,220],"can":[61],"alter":[62],"EHC":[63,179,244],"and":[64,100,121,131,133,139,148,172],"drug":[65],"exposure.":[66],"Here,":[67],"we":[68],"evaluated":[69],"effects":[71,156],"this":[73,264],"potential":[74,265],"drug-transporter":[75],"interaction":[76],"on":[77,89,160,169,188],"MPA-PK":[78],"a":[80],"cohort":[81,227],"patients":[83,108,167,186],"with":[84,109],"childhood-onset":[85,110],"systemic":[86,111],"lupus":[87,112],"erythematosus":[88],"mycophenolate":[90],"mofetil":[91],"therapy.":[92],"MATERIALS":[93],"AND":[94],"METHODS:":[95],"Full":[96],"concentration-time":[98],"profiles":[99],"demographics":[101],"including":[102],"comedications":[103],"were":[104,141,151,168],"available":[105],"for":[106],"19":[107,166],"erythematosus.":[113],"Concentrations":[114],"at":[115],"predose":[116],"(C(trough)),":[117],"9":[118],"hour":[119],"(C\u2089),":[120],"nadir":[122],"(C(nadir);":[123],"defined":[124],"as":[125],"lowest":[127],"concentration":[128,196],"between":[129],"C(max)":[130],"C\u2089),":[132],"area":[134],"under":[135],"curve":[137],"(AUC\u2080\u208b\u2081\u2082":[138],"AUC\u2086\u208b\u2081\u2082)":[140],"assessed":[142],"using":[143],"standard":[144],"methods":[145],"(WinNonlin5.1).":[146],"AUC6-12/AUC\u2080\u208b\u2081\u2082":[147],"C\u2089/C(nadir)":[149,218],"ratios":[150],"used":[152],"evaluate":[154],"NSAID":[158,170,189],"treatment":[159,171],"MPA-PK.":[161],"RESULTS:":[162],"Eleven":[163],"out":[164],"did":[173],"not":[174,187],"show":[175],"visual":[176],"evidence":[177,192],"their":[181,203],"PK":[182,204],"profile.":[183],"In":[184],"contrast,":[185],"therapy":[190],"showed":[191],"EHC-related":[194],"increase":[197],"later":[200],"profiles,":[205],"typically":[206],"after":[207],"6":[208],"hours.":[209],"This":[210],"phenomenon":[211],"could":[212],"be":[213],"well":[214],"characterized":[215],"by":[216],"ratio,":[219],"was":[221],"significantly":[222],"lower":[223,243],"NSAID-treated":[226],"(P":[228],"<":[229],"0.01).":[230],"CONCLUSIONS:":[231],"These":[232],"preliminary":[233],"data":[234],"suggest":[235],"that":[236],"concomitant":[238],"intake":[239],"NSAIDs":[241],"may":[242],"possibly":[247],"through":[248],"inhibition":[250],"transport":[253],"MPA-G.":[255],"Further":[256],"mechanism-based":[257],"studies":[258],"needed":[260],"further":[262],"elucidate":[263],"transporter":[266],"interaction.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}