{"id":"https://openalex.org/W2035782862","doi":"https://doi.org/10.1021/ja4031193","title":"Proteomics Guided Discovery of Flavopeptins: Anti-proliferative Aldehydes Synthesized by a Reductase Domain-Containing Non-ribosomal Peptide Synthetase","display_name":"Proteomics Guided Discovery of Flavopeptins: Anti-proliferative Aldehydes Synthesized by a Reductase Domain-Containing Non-ribosomal Peptide Synthetase","publication_year":2013,"publication_date":"2013-06-13","ids":{"openalex":"https://openalex.org/W2035782862","doi":"https://doi.org/10.1021/ja4031193","mag":"2035782862","pmid":"https://pubmed.ncbi.nlm.nih.gov/23763305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752840"},"language":"en","primary_location":{"id":"doi:10.1021/ja4031193","doi":"https://doi.org/10.1021/ja4031193","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja4031193","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752840","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030046258","display_name":"Yunqiu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunqiu Chen","raw_affiliation_strings":["Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084068146","display_name":"Ryan A. McClure","orcid":"https://orcid.org/0000-0002-0163-9290","observed_orcids":["https://orcid.org/0000-0002-0163-9290"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. McClure","raw_affiliation_strings":["Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101704537","display_name":"Yupeng Zheng","orcid":"https://orcid.org/0000-0002-3351-5161","observed_orcids":["https://orcid.org/0000-0002-3351-5161"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yupeng Zheng","raw_affiliation_strings":["Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063010516","display_name":"Regan J. Thomson","orcid":"https://orcid.org/0000-0001-5546-4038","observed_orcids":["https://orcid.org/0000-0001-5546-4038"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Regan J. Thomson","raw_affiliation_strings":["Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076257201","display_name":"Neil L. Kelleher","orcid":"https://orcid.org/0000-0002-8815-3372","observed_orcids":["https://orcid.org/0000-0002-8815-3372"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil L. Kelleher","raw_affiliation_strings":["Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063010516","https://openalex.org/A5076257201"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9372,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89176977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"135","issue":"28","first_page":"10449","last_page":"10456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.796999990940094},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cysteine-protease-inhibition","display_name":"cysteine protease inhibition","score":0.9039999842643738},{"id":"https://openalex.org/keywords/papain","display_name":"papain","score":0.7749999761581421},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":1.0},{"id":"https://openalex.org/keywords/20s-proteasome-inhibition","display_name":"20S proteasome inhibition","score":0.9330000281333923},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.7879999876022339},{"id":"https://openalex.org/keywords/secondary-metabolism","display_name":"secondary metabolism","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.732150137424469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6760752201080322},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6712853908538818},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5858315825462341},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.48686331510543823},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41774648427963257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1803930103778839},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08649373054504395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010206","descriptor_name":"Papain","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010206","descriptor_name":"Papain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja4031193","doi":"https://doi.org/10.1021/ja4031193","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja4031193","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:23763305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23763305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3752840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3752840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3725819159","display_name":null,"funder_award_id":"GM067725","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5554684759","display_name":"Mass Spectrometric Studies of Thiotemplate Biosynthesis","funder_award_id":"R01GM067725","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1934400729","https://openalex.org/W1982793579","https://openalex.org/W1988187251","https://openalex.org/W1999042605","https://openalex.org/W2004263583","https://openalex.org/W2006032735","https://openalex.org/W2006564463","https://openalex.org/W2009088464","https://openalex.org/W2020161436","https://openalex.org/W2021703849","https://openalex.org/W2027277404","https://openalex.org/W2034280081","https://openalex.org/W2038062002","https://openalex.org/W2052591459","https://openalex.org/W2061202321","https://openalex.org/W2062581107","https://openalex.org/W2090199399","https://openalex.org/W2094558592","https://openalex.org/W2094966831","https://openalex.org/W2107881585","https://openalex.org/W2113546943","https://openalex.org/W2127340453","https://openalex.org/W2131887397","https://openalex.org/W2137651777","https://openalex.org/W2149901522","https://openalex.org/W2156077969","https://openalex.org/W2159923211","https://openalex.org/W2169872465","https://openalex.org/W2169942471"],"related_works":["https://openalex.org/W2318600233","https://openalex.org/W2335199189","https://openalex.org/W3191538960","https://openalex.org/W2007977393","https://openalex.org/W4386445428","https://openalex.org/W2795147650","https://openalex.org/W3041428447","https://openalex.org/W7143494670","https://openalex.org/W2395523206","https://openalex.org/W3095779830"],"abstract_inverted_index":{"Due":[0],"to":[1,74],"the":[2,10,36,65,69,80,89,92,149,153,193],"importance":[3],"of":[4,12,24,38,68,82,86,109,152,162,174],"proteases":[5,32,184],"in":[6,35,102,128,131],"regulating":[7],"cellular":[8],"processes,":[9],"development":[11],"protease":[13],"inhibitors":[14],"has":[15,72],"garnered":[16],"great":[17],"attention.":[18],"Peptide-based":[19],"aldehydes":[20,54],"are":[21,134],"a":[22,48,83,106,119,137,142,156],"class":[23],"compounds":[25],"that":[26,122],"exhibit":[27,178],"inhibitory":[28],"activities":[29,181,201],"against":[30,182,202],"various":[31],"and":[33,43,62,91,166,171,188,205],"proteasomes":[34],"context":[37],"anti-proliferative":[39,200],"treatments":[40],"for":[41,124,148],"cancer":[42],"other":[44],"diseases.":[45],"More":[46],"than":[47],"dozen":[49],"peptide-based":[50],"natural":[51],"products":[52],"containing":[53,141],"have":[55],"been":[56],"discovered":[57],"such":[58,185],"as":[59,186,190,192],"chymostatin,":[60],"leupeptin,":[61],"fellutamide;":[63],"however,":[64],"biosynthetic":[66,94],"origin":[67],"aldehyde":[70],"functionality":[71],"yet":[73],"be":[75],"elucidated.":[76],"Herein":[77],"we":[78],"describe":[79],"discovery":[81],"new":[84],"group":[85],"lipopeptide":[87],"aldehydes,":[88],"flavopeptins,":[90],"corresponding":[93],"pathway":[95],"arising":[96],"from":[97],"an":[98],"orphan":[99],"gene":[100],"cluster":[101],"Streptomyces":[103,110],"sp.":[104],"NRRL-F6652,":[105],"close":[107],"relative":[108],"flavogriseus":[111],"ATCC":[112],"33331.":[113],"This":[114],"research":[115],"was":[116],"initiated":[117],"using":[118],"proteomics":[120],"approach":[121],"screens":[123],"expressed":[125],"enzymes":[126],"involved":[127],"secondary":[129],"metabolism":[130],"microorganisms.":[132],"Flavopeptins":[133,177],"synthesized":[135],"through":[136],"non-ribosomal":[138],"peptide":[139,154,160],"synthetase":[140],"terminal":[143],"NAD(P)H-dependent":[144],"reductase":[145],"domain":[146],"likely":[147],"reductive":[150],"release":[151],"with":[155],"C-terminal":[157],"aldehyde.":[158],"Solid-phase":[159],"synthesis":[161],"several":[163],"flavopeptin":[164],"species":[165],"derivatives":[167],"enabled":[168],"structural":[169],"verification":[170],"subsequent":[172],"screening":[173],"biological":[175],"activity.":[176],"sub-micromolar":[179],"inhibition":[180],"cysteine":[183],"papain":[187],"calpain":[189],"well":[191],"human":[194],"20S":[195],"proteasome.":[196],"They":[197],"also":[198],"show":[199],"multiple":[203],"myeloma":[204],"lymphoma":[206],"cell":[207],"lines.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}