{"id":"https://openalex.org/W2035743490","doi":"https://doi.org/10.1038/jcbfm.2009.281","title":"Increased Nuclear Apoptosis-Inducing Factor after Transient Focal Ischemia: A 12/15-Lipoxygenase-dependent Organelle Damage Pathway","display_name":"Increased Nuclear Apoptosis-Inducing Factor after Transient Focal Ischemia: A 12/15-Lipoxygenase-dependent Organelle Damage Pathway","publication_year":2010,"publication_date":"2010-01-13","ids":{"openalex":"https://openalex.org/W2035743490","doi":"https://doi.org/10.1038/jcbfm.2009.281","mag":"2035743490","pmid":"https://pubmed.ncbi.nlm.nih.gov/20068575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915762"},"language":"en","primary_location":{"id":"doi:10.1038/jcbfm.2009.281","doi":"https://doi.org/10.1038/jcbfm.2009.281","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.2009.281","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.281","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.281","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049403790","display_name":"Stefanie Pallast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Pallast","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062438568","display_name":"Ken Arai","orcid":"https://orcid.org/0000-0003-1615-3258","observed_orcids":["https://orcid.org/0000-0003-1615-3258"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Arai","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047056425","display_name":"Anton Pekcec","orcid":"https://orcid.org/0000-0001-9045-4740","observed_orcids":["https://orcid.org/0000-0001-9045-4740"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton Pekcec","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053396624","display_name":"Kaz\u0131m Yi\u011fitkanl\u0131","orcid":"https://orcid.org/0000-0003-0628-0173","observed_orcids":["https://orcid.org/0000-0003-0628-0173"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazim Yigitkanli","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061961346","display_name":"Zhanyang Yu","orcid":"https://orcid.org/0000-0003-3787-8127","observed_orcids":["https://orcid.org/0000-0003-3787-8127"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhanyang Yu","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364306","display_name":"Xiaoying Wang","orcid":"https://orcid.org/0000-0003-3636-7931","observed_orcids":["https://orcid.org/0000-0003-3636-7931","https://orcid.org/0000-0003-1803-5255"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoying Wang","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091447153","display_name":"Eng H. Lo","orcid":"https://orcid.org/0000-0002-9327-2915","observed_orcids":["https://orcid.org/0000-0002-9327-2915"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng H Lo","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067880502","display_name":"Klaus van Leyen","orcid":"https://orcid.org/0000-0003-1032-3754","observed_orcids":["https://orcid.org/0000-0003-1032-3754"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Klaus van Leyen","raw_affiliation_strings":["Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067880502"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.5835,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.90406545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"6","first_page":"1157","last_page":"1167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.2524000108242035,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis-inducing-factor","display_name":"apoptosis-inducing factor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/12-15-lipoxygenase","display_name":"12/15-lipoxygenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transient-focal-cerebral-ischemia","display_name":"transient focal cerebral ischemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.968999981880188},{"id":"https://openalex.org/keywords/baicalein","display_name":"baicalein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6600000262260437},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.847000002861023},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.777999997138977},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-damage","display_name":"endoplasmic reticulum damage","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6790000200271606},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.5410000085830688},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2781466915","wikidata":"https://www.wikidata.org/wiki/Q2879363","display_name":"Baicalein","level":2,"score":0.9056217670440674},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7784814834594727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6158879399299622},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6144613027572632},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5925560593605042},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5595479011535645},{"id":"https://openalex.org/C172043667","wikidata":"https://www.wikidata.org/wiki/Q4780529","display_name":"Apoptosis-inducing factor","level":5,"score":0.4944474697113037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3793022930622101},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37146836519241333},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36798131465911865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3335767984390259},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.19568651914596558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19142907857894897},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051033","descriptor_name":"Apoptosis Inducing Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051033","descriptor_name":"Apoptosis Inducing Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/jcbfm.2009.281","doi":"https://doi.org/10.1038/jcbfm.2009.281","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.2009.281","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.281","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2111462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915762","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2915762","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915762","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cereb Blood Flow Metab","raw_type":"Text"},{"id":"pmid:20068575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20068575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/jcbfm.2009.281","doi":"https://doi.org/10.1038/jcbfm.2009.281","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.2009.281","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.281","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G103539761","display_name":null,"funder_award_id":"P01NS555104","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5687052341","display_name":"12/15-Lipoxygenase and neurovascular damage following cardiac arrest","funder_award_id":"R01NS049430","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7786010504","display_name":"CD47 as a neurovascular target for stroke therapy","funder_award_id":"R01NS053560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035743490.pdf"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1525431558","https://openalex.org/W1562310953","https://openalex.org/W1966928113","https://openalex.org/W1984035373","https://openalex.org/W1992565982","https://openalex.org/W1994662389","https://openalex.org/W2000080307","https://openalex.org/W2007794772","https://openalex.org/W2020671984","https://openalex.org/W2040249823","https://openalex.org/W2043951237","https://openalex.org/W2050257120","https://openalex.org/W2054068918","https://openalex.org/W2064708316","https://openalex.org/W2064766999","https://openalex.org/W2074194694","https://openalex.org/W2079064010","https://openalex.org/W2085459880","https://openalex.org/W2091712620","https://openalex.org/W2116176075","https://openalex.org/W2130971769","https://openalex.org/W2137141016","https://openalex.org/W2140605096","https://openalex.org/W2168531927","https://openalex.org/W2322726597","https://openalex.org/W4240524442"],"related_works":["https://openalex.org/W2552098855","https://openalex.org/W2137141016","https://openalex.org/W2045771434","https://openalex.org/W2168531927","https://openalex.org/W49238952","https://openalex.org/W2074194694","https://openalex.org/W2034737379","https://openalex.org/W2059006262","https://openalex.org/W2415443560","https://openalex.org/W7098618226"],"abstract_inverted_index":{"12/15-lipoxygenase":[0],"(12/15-LOX)":[1],"contributes":[2],"to":[3,34,103,106,175],"acute":[4],"neuronal":[5,36,91],"injury":[6],"and":[7,30,66,161],"edema":[8],"formation":[9],"in":[10,25,45,166],"mouse":[11,50],"models":[12],"of":[13,28,49,57,69,82,90,130],"middle":[14],"cerebral":[15],"artery":[16],"occlusion":[17],"(MCAO).":[18],"The":[19,59],"apoptosis-inducing":[20],"factor":[21],"(AIF)":[22],"is":[23,110],"implicated":[24],"caspase-independent":[26],"forms":[27],"apoptosis,":[29],"has":[31],"been":[32],"linked":[33],"ischemic":[35],"cell":[37,87,137,149,169],"death.":[38],"We":[39],"show":[40,95,158],"here":[41],"that":[42,96,159,172],"increased":[43],"AIF":[44,104,162],"the":[46,64,79,107,113,131,136],"peri-ischemic":[47],"cortex":[48],"colocalizes":[51],"with":[52],"12/15-LOX":[53,60,97,114,160],"after":[54,99],"2":[55],"h":[56],"MCAO.":[58],"inhibitor":[61,115],"baicalein":[62,116],"prevents":[63],"increase":[65],"nuclear":[67],"localization":[68],"AIF,":[70],"suggesting":[71,148],"this":[72],"pathway":[73,171],"may":[74,173],"be":[75],"partially":[76],"responsible":[77],"for":[78],"neuroprotective":[80],"qualities":[81],"baicalein.":[83],"Using":[84],"an":[85],"established":[86],"line":[88],"model":[89],"oxidative":[92],"stress,":[93],"we":[94],"activated":[98],"glutathione":[100],"depletion":[101],"leads":[102],"translocation":[105],"nucleus,":[108],"which":[109],"abrogated":[111],"by":[112],"(control:":[117,138],"19.3%+/-6.8%":[118],"versus":[119,122,140,143],"Glutamate:":[120],"64.0%+/-8.2%":[121],"glutamate":[123,144],"plus":[124,145],"baicalein:":[125,146],"11.4%+/-2.2%).":[126],"Concomitantly,":[127],"resident":[128],"proteins":[129],"ER":[132],"are":[133,163],"dispersed":[134],"throughout":[135],"31.0%+/-8.4%":[139],"glutamate:":[141],"70.0%+/-5.5%":[142],"8.0%+/-2.7%),":[147],"death":[150,170],"through":[151],"organelle":[152],"damage.":[153,178],"Taken":[154],"together,":[155],"these":[156],"findings":[157],"sequential":[164],"actors":[165],"a":[167],"common":[168],"contribute":[174],"stroke-induced":[176],"brain":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
