{"id":"https://openalex.org/W2035667813","doi":"https://doi.org/10.1056/nejmoa050496","title":"The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure","display_name":"The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure","publication_year":2005,"publication_date":"2005-03-07","ids":{"openalex":"https://openalex.org/W2035667813","doi":"https://doi.org/10.1056/nejmoa050496","mag":"2035667813","pmid":"https://pubmed.ncbi.nlm.nih.gov/15753115"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa050496","doi":"https://doi.org/10.1056/nejmoa050496","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa050496","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa050496?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa050496?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017160240","display_name":"John G.F. Cleland","orcid":"https://orcid.org/0000-0002-1471-7016","observed_orcids":["https://orcid.org/0000-0002-1471-7016"]},"institutions":[{"id":"https://openalex.org/I2801269832","display_name":"Castle Hill Hospital","ror":"https://ror.org/042asnw05","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800043709","https://openalex.org/I2801269832"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John G.F. Cleland","raw_affiliation_strings":["Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom. j.g.cleland@hull.ac.uk","Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom. j.g.cleland@hull.ac.uk","institution_ids":["https://openalex.org/I2801269832"]},{"raw_affiliation_string":"Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull, United Kingdom","institution_ids":["https://openalex.org/I2801269832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064135519","display_name":"Jean\u2010Claude Daubert","orcid":"https://orcid.org/0000-0002-8507-2761","observed_orcids":["https://orcid.org/0000-0002-8507-2761"]},"institutions":[{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Claude Daubert","raw_affiliation_strings":["Department of Cardiology, H\u00f4pital Pontchaillou, Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, H\u00f4pital Pontchaillou, Rennes, France","institution_ids":["https://openalex.org/I4210124872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028685517","display_name":"Erland Erdmann","orcid":"https://orcid.org/0000-0002-9887-3736","observed_orcids":["https://orcid.org/0000-0002-9887-3736"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erland Erdmann","raw_affiliation_strings":["Klinik III f\u00fcr Innere Medizin der Universit\u00e4t zu K\u00f6ln, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik III f\u00fcr Innere Medizin der Universit\u00e4t zu K\u00f6ln, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031103837","display_name":"Nick Freemantle","orcid":"https://orcid.org/0000-0001-5807-5740","observed_orcids":["https://orcid.org/0000-0001-5807-5740"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Freemantle","raw_affiliation_strings":["University of Birmingham, Edgbaston, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Birmingham, Edgbaston, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028563536","display_name":"Daniel Gras","orcid":"https://orcid.org/0000-0002-7980-6036","observed_orcids":["https://orcid.org/0000-0002-7980-6036"]},"institutions":[{"id":"https://openalex.org/I4210135085","display_name":"Nouvelles Cliniques Nantaises","ror":"https://ror.org/03731ze76","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135085"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Gras","raw_affiliation_strings":["Nouvelles Cliniques Nantaises, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nouvelles Cliniques Nantaises, Nantes, France","institution_ids":["https://openalex.org/I4210135085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005212352","display_name":"LUKAS J. KAPPENBERGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Kappenberger","raw_affiliation_strings":["Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029606867","display_name":"Luigi Tavazzi","orcid":"https://orcid.org/0000-0003-4448-5209","observed_orcids":["https://orcid.org/0000-0003-4448-5209"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Tavazzi","raw_affiliation_strings":["Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I4210151645"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":275.4315,"has_fulltext":true,"cited_by_count":6276,"citation_normalized_percentile":{"value":0.9999754,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"352","issue":"15","first_page":"1539","last_page":"1549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9599999785423279},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiac-dyssynchrony","display_name":"cardiac dyssynchrony","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6970000267028809},{"id":"https://openalex.org/keywords/morbidity","display_name":"morbidity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7400000095367432},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/end-systolic-volume","display_name":"end-systolic volume","score":0.75},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cardiac-implantable-electronic-devices","display_name":"cardiac implantable electronic devices","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9343643188476562},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.8780563473701477},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8186925053596497},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8153034448623657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7748982906341553},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7288281917572021},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6784665584564209},{"id":"https://openalex.org/C2776720267","wikidata":"https://www.wikidata.org/wiki/Q7920314","display_name":"Ventricular dyssynchrony","level":5,"score":0.5983846187591553},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5240876078605652},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.48229506611824036},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2195858359336853}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1056/nejmoa050496","doi":"https://doi.org/10.1056/nejmoa050496","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa050496","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa050496?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:15753115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15753115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:eprints.gla.ac.uk:128401","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/128401/1/128401.pdf","pdf_url":"http://eprints.gla.ac.uk/128401/1/128401.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1322802","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1322802/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NEW ENGL J MED , 352 (15) 1539 - 1549. (2005)","raw_type":"Article"},{"id":"pmh:oai:iris.unil.ch:iris/187965","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/187965","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:lra.le.ac.uk:2381/17600","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/17600","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Web of Science","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/dd15f15c-a60c-4c00-a6de-9ea656e32258","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/dd15f15c-a60c-4c00-a6de-9ea656e32258","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cleland, JGF, Daubert, JC, Erdmann, E, Freemantle, N, Gras, D, Kappenberger, L & Tavazzi, L 2005, 'The effect of cardiac resynchronization on morbidity and mortality in heart failure', New England Journal of Medicine, vol. 352, pp. 1539-1549. https://doi.org/10.1056/NEJMoa050496","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/f83e4080-aadb-11da-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/f83e4080-aadb-11da-bee9-02004c4f4f50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cleland, J G, Daubert, J C, Erdmann, E, Freemantle, N, Gras, D, Kappenberger, L, Tavazzi, L, Espersen, G T & Vesterlund, T 2005, 'The effect of cardiac resynchronization on morbidity and mortality in heart failure', The New England Journal of Medicine, vol. 352, no. 15, pp. 1539-1549.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:serval.unil.ch:BIB_7F2AAACA353A","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_7F2AAACA353A","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New England Journal of Medicine, vol. 352, no. 15, pp. 1539-49","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1056/nejmoa050496","doi":"https://doi.org/10.1056/nejmoa050496","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa050496","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa050496?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035667813.pdf","grobid_xml":"https://content.openalex.org/works/W2035667813.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1565240145","https://openalex.org/W1964267904","https://openalex.org/W1986817239","https://openalex.org/W1990639292","https://openalex.org/W1995307102","https://openalex.org/W1995935850","https://openalex.org/W1998245427","https://openalex.org/W2025102558","https://openalex.org/W2028759024","https://openalex.org/W2047198412","https://openalex.org/W2062760666","https://openalex.org/W2071686284","https://openalex.org/W2075175982","https://openalex.org/W2079194870","https://openalex.org/W2081403760","https://openalex.org/W2102342133","https://openalex.org/W2130907431","https://openalex.org/W2159290703","https://openalex.org/W2160571019","https://openalex.org/W2169108049","https://openalex.org/W2229050495","https://openalex.org/W2296998040","https://openalex.org/W2318628277","https://openalex.org/W2323458614","https://openalex.org/W2328926651","https://openalex.org/W2409382494","https://openalex.org/W2567948445","https://openalex.org/W2797935920","https://openalex.org/W3023522280","https://openalex.org/W3144470180","https://openalex.org/W4232675063","https://openalex.org/W4233742069","https://openalex.org/W4245244523","https://openalex.org/W4301341292"],"related_works":["https://openalex.org/W2966052071","https://openalex.org/W4322753448","https://openalex.org/W1987129745","https://openalex.org/W2764836990","https://openalex.org/W1995471615","https://openalex.org/W3000648810","https://openalex.org/W4255532974","https://openalex.org/W2604199795","https://openalex.org/W1969921101","https://openalex.org/W2167339940"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cardiac":[1],"resynchronization":[2,196,242],"reduces":[3,251],"symptoms":[4,222,244],"and":[5,22,31,52,112,206,220,223,238,245,250,253],"improves":[6,243],"left":[7,18,48,216],"ventricular":[8,19,49,217],"function":[9],"in":[10,129,138,162,170,261,280],"many":[11],"patients":[12,109,128,137,234],"with":[13,35,70,135,168,192,235],"heart":[14,44,236],"failure":[15,45,237],"due":[16,46],"to":[17,47,64,80,155,187,263],"systolic":[20,50],"dysfunction":[21,51],"cardiac":[23,53,71,195,239,241],"dyssynchrony.":[24],"We":[25],"evaluated":[26],"its":[27],"effects":[28],"on":[29],"morbidity":[30],"mortality.":[32],"METHODS:":[33],"Patients":[34],"New":[36],"York":[37],"Heart":[38],"Association":[39],"class":[40],"III":[41],"or":[42,69,85],"IV":[43],"dyssynchrony":[54],"who":[55],"were":[56,61,110,159],"receiving":[57],"standard":[58,267],"pharmacologic":[59,268],"therapy":[60,67],"randomly":[62],"assigned":[63],"receive":[65],"medical":[66,193],"alone":[68],"resynchronization.":[72],"The":[73,94,120,270],"primary":[74,121],"end":[75,97,122],"point":[76,98,123],"was":[77,99,124],"the":[78,130,139,163,171,198,202,207,210,215,224,246,254],"time":[79],"death":[81,100],"from":[82,101],"any":[83,102],"cause":[84],"an":[86],"unplanned":[87],"hospitalization":[88],"for":[89,114,229],"a":[90,115,273],"major":[91],"cardiovascular":[92],"event.":[93],"principal":[95],"secondary":[96],"cause.":[103],"RESULTS:":[104],"A":[105],"total":[106],"of":[107,117,209,226,248,256,272],"813":[108],"enrolled":[111],"followed":[113],"mean":[116],"29.4":[118],"months.":[119],"reached":[125],"by":[126,266],"159":[127],"cardiac-resynchronization":[131,164,274],"group,":[132,165],"as":[133,166],"compared":[134,167,191],"224":[136],"medical-therapy":[140,172],"group":[141,173],"(39":[142],"percent":[143,151,175,183],"vs.":[144,176],"55":[145],"percent;":[146,178],"hazard":[147,179],"ratio,":[148],"0.63;":[149],"95":[150,182],"confidence":[152,184],"interval,":[153,185],"0.51":[154],"0.77;":[156],"P<0.001).":[157],"There":[158],"82":[160],"deaths":[161],"120":[169],"(20":[174],"30":[177],"ratio":[180],"0.64;":[181],"0.48":[186],"0.85;":[188],"P<0.002).":[189],"As":[190],"therapy,":[194],"reduced":[197],"interventricular":[199],"mechanical":[200],"delay,":[201],"end-systolic":[203],"volume":[204],"index,":[205],"area":[208],"mitral":[211],"regurgitant":[212],"jet;":[213],"increased":[214],"ejection":[218],"fraction;":[219],"improved":[221],"quality":[225,247],"life":[227,249],"(P<0.01":[228],"all":[230],"comparisons).":[231],"CONCLUSIONS:":[232],"In":[233],"dyssynchrony,":[240],"complications":[252],"risk":[255],"death.":[257],"These":[258],"benefits":[259],"are":[260],"addition":[262],"those":[264],"afforded":[265],"therapy.":[269],"implantation":[271],"device":[275],"should":[276],"routinely":[277],"be":[278],"considered":[279],"such":[281],"patients.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":108},{"year":2025,"cited_by_count":130},{"year":2024,"cited_by_count":149},{"year":2023,"cited_by_count":201},{"year":2022,"cited_by_count":188},{"year":2021,"cited_by_count":204},{"year":2020,"cited_by_count":225},{"year":2019,"cited_by_count":246},{"year":2018,"cited_by_count":247},{"year":2017,"cited_by_count":267},{"year":2016,"cited_by_count":286},{"year":2015,"cited_by_count":335},{"year":2014,"cited_by_count":312},{"year":2013,"cited_by_count":373},{"year":2012,"cited_by_count":376}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}