{"id":"https://openalex.org/W2035644133","doi":"https://doi.org/10.1158/0008-5472.can-03-0560","title":"Decreased Expression of Early Growth Response-1 and Its Role in Uterine Leiomyoma Growth","display_name":"Decreased Expression of Early Growth Response-1 and Its Role in Uterine Leiomyoma Growth","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2035644133","doi":"https://doi.org/10.1158/0008-5472.can-03-0560","mag":"2035644133","pmid":"https://pubmed.ncbi.nlm.nih.gov/15231681"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-03-0560","doi":"https://doi.org/10.1158/0008-5472.can-03-0560","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-0560","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039209782","display_name":"Makio Shozu","orcid":"https://orcid.org/0000-0002-7247-2205","observed_orcids":["https://orcid.org/0000-0002-7247-2205"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makio Shozu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112464252","display_name":"Kouichi Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichi Murakami","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005720762","display_name":"Tomoya Segawa","orcid":"https://orcid.org/0000-0001-6759-4438","observed_orcids":["https://orcid.org/0000-0001-6759-4438"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Segawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112566025","display_name":"Tadayuki Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayuki Kasai","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002119477","display_name":"Hiroshi Ishikawa","orcid":"https://orcid.org/0000-0003-1116-6885","observed_orcids":["https://orcid.org/0000-0003-1116-6885"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ishikawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034668131","display_name":"Kazunori Shinohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Shinohara","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108389559","display_name":"Masahiko Okada","orcid":"https://orcid.org/0009-0008-5084-0717","observed_orcids":["https://orcid.org/0009-0008-5084-0717","https://orcid.org/0009-0008-9752-8990"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Okada","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101405899","display_name":"Masak\u00ed Inoue","orcid":"https://orcid.org/0000-0002-2912-9305","observed_orcids":["https://orcid.org/0000-0002-2912-9305"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Inoue","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I10091056"],"apc_list":null,"apc_paid":null,"fwci":3.074,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89471698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"64","issue":"13","first_page":"4677","last_page":"4684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-growth-response-1","display_name":"early growth response 1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/uterine-fibroids","display_name":"uterine fibroids","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7590000033378601},{"id":"https://openalex.org/keywords/myometrium","display_name":"myometrium","score":0.859000027179718},{"id":"https://openalex.org/keywords/leuprolide-acetate","display_name":"leuprolide","score":0.8880000114440918},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9509999752044678},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.43799999356269836},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/5q31","display_name":"5q31","score":0.7300000190734863},{"id":"https://openalex.org/keywords/leiomyoma-growth","display_name":"leiomyoma growth","score":0.6460000276565552},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.8807418346405029},{"id":"https://openalex.org/C3017725331","wikidata":"https://www.wikidata.org/wiki/Q556281","display_name":"Uterine leiomyoma","level":3,"score":0.7806244492530823},{"id":"https://openalex.org/C2777795800","wikidata":"https://www.wikidata.org/wiki/Q4667534","display_name":"Leiomyoma","level":2,"score":0.6757121086120605},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5737488269805908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5612857341766357},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.5067091584205627},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.478402704000473},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47686395049095154},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45189571380615234},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4282929599285126},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41213545203208923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3978385925292969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39600634574890137},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36355090141296387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21643155813217163},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.1792149841785431},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15086892247200012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10943785309791565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07541587948799133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07153290510177612}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025743","descriptor_name":"HMGA2 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025743","descriptor_name":"HMGA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-03-0560","doi":"https://doi.org/10.1158/0008-5472.can-03-0560","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-0560","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15231681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15231681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.7265","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7265","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/64/13/4677.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W105381371","https://openalex.org/W1533942578","https://openalex.org/W1567559129","https://openalex.org/W1603788311","https://openalex.org/W1927347481","https://openalex.org/W1970999822","https://openalex.org/W1980183006","https://openalex.org/W1982023759","https://openalex.org/W1986100686","https://openalex.org/W1986178112","https://openalex.org/W1988177096","https://openalex.org/W2001178280","https://openalex.org/W2002050823","https://openalex.org/W2002126108","https://openalex.org/W2017802973","https://openalex.org/W2019730022","https://openalex.org/W2023639042","https://openalex.org/W2026883932","https://openalex.org/W2027154318","https://openalex.org/W2030539074","https://openalex.org/W2031118736","https://openalex.org/W2035482668","https://openalex.org/W2037872261","https://openalex.org/W2039462089","https://openalex.org/W2047064684","https://openalex.org/W2047633774","https://openalex.org/W2050552159","https://openalex.org/W2053544423","https://openalex.org/W2057582406","https://openalex.org/W2058537601","https://openalex.org/W2058727657","https://openalex.org/W2059671369","https://openalex.org/W2066645560","https://openalex.org/W2066650638","https://openalex.org/W2067762187","https://openalex.org/W2070073216","https://openalex.org/W2072040977","https://openalex.org/W2075514051","https://openalex.org/W2079003535","https://openalex.org/W2081662078","https://openalex.org/W2090105093","https://openalex.org/W2090585013","https://openalex.org/W2119420631","https://openalex.org/W2136904377","https://openalex.org/W2138134383","https://openalex.org/W2157481140","https://openalex.org/W2159435444","https://openalex.org/W2164777399","https://openalex.org/W2324375367","https://openalex.org/W2326525236","https://openalex.org/W2400633027","https://openalex.org/W2404858459","https://openalex.org/W2416196194","https://openalex.org/W2473373947","https://openalex.org/W4234318199"],"related_works":["https://openalex.org/W7095222381","https://openalex.org/W2056939505","https://openalex.org/W2068563793","https://openalex.org/W2012128541","https://openalex.org/W7096964525","https://openalex.org/W290786891","https://openalex.org/W2116591579","https://openalex.org/W2001810755","https://openalex.org/W2002050823","https://openalex.org/W2002737507"],"abstract_inverted_index":{"Expression":[0],"of":[1,25,40,49,63,79,110,116,123,139,192,198,212],"early":[2],"growth":[3,11,44,195,217],"response":[4],"(Egr)-1,":[5],"a":[6,203,231],"transcriptional":[7],"factor":[8],"implicated":[9],"in":[10,15,30,45,54,65,82,141,152,172,184,194,221],"regulation,":[12],"is":[13],"suppressed":[14],"several":[16],"malignant":[17],"tumors.":[18],"The":[19],"present":[20],"study":[21],"investigated":[22],"the":[23,97,117,124,190],"expression":[24,70,109,200],"Egr-1":[26,41,50,80,99,111,118,144,171,179,193,199,213,224],"and":[27,33,120,131,159,214,229],"related":[28],"genes":[29],"uterine":[31],"leiomyoma":[32,46,158,173,185,235],"normal":[34,83,160],"myometrium":[35,84],"to":[36,42,60,148],"determine":[37],"possible":[38],"contributions":[39],"neoplastic":[43],"cells.":[47,186,223],"Levels":[48],"transcripts":[51],"were":[52],"decreased":[53,108],"all":[55],"leiomyomas":[56],"(n":[57,93,104],"=":[58,94,105],"20)":[59],"approximately":[61],"10%":[62],"levels":[64,78,211],"corresponding":[66],"myometrium,":[67],"where":[68],"basal":[69],"was":[71],"high.":[72],"Preoperative":[73],"leuprorelin":[74],"acetate":[75],"therapy":[76],"increased":[77],"mRNA":[81],"only.":[85],"Northern":[86],"blot":[87,102,114],"analysis":[88,103,115,122,165],"using":[89],"additional":[90],"sample":[91],"sets":[92],"5)":[95,106],"revealed":[96,133,166],"full-length":[98],"transcript.":[100],"Western":[101],"confirmed":[107],"protein.":[112],"Southern":[113],"gene":[119],"microsatellite":[121],"chromosomal":[125],"location":[126],"at":[127],"5q31":[128],"(D5S414,":[129],"D5S500,":[130],"D5S476)":[132],"neither":[134],"DNA":[135,176],"recombination":[136],"nor":[137],"loss":[138],"heterozygosity":[140],"leiomyomas.":[142],"Moreover,":[143],"retained":[145,175],"identical":[146],"responsiveness":[147],"phorbol":[149,168],"12-myristate":[150,169],"13-acetate":[151],"primary":[153],"cultures":[154],"derived":[155],"from":[156],"both":[157],"tissues.":[161],"Electrophoretic":[162],"mobility":[163],"shift":[164],"that":[167,208],"13-acetate-induced":[170],"cells":[174],"binding":[177],"ability.":[178],"thus":[180],"appears":[181],"functionally":[182],"intact":[183],"Finally,":[187],"consistent":[188],"with":[189],"role":[191],"inhibition,":[196],"transfection":[197],"vector":[201],"into":[202],"myometrial":[204],"cell":[205],"line":[206],"(KW)":[207],"expresses":[209],"low":[210],"displays":[215],"rapid":[216],"inhibited":[218],"thymidine":[219],"uptake":[220],"these":[222],"may":[225],"display":[226],"tumor-suppressing":[227],"activity":[228],"offers":[230],"potential":[232],"target":[233],"for":[234],"management.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}