{"id":"https://openalex.org/W2035635853","doi":"https://doi.org/10.1002/pbc.24443","title":"Potential role for statins in sickle cell disease","display_name":"Potential role for statins in sickle cell disease","publication_year":2012,"publication_date":"2012-12-31","ids":{"openalex":"https://openalex.org/W2035635853","doi":"https://doi.org/10.1002/pbc.24443","mag":"2035635853","pmid":"https://pubmed.ncbi.nlm.nih.gov/23281161"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.24443","doi":"https://doi.org/10.1002/pbc.24443","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.24443","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011860608","display_name":"Soheir S. Adam","orcid":"https://orcid.org/0000-0003-0076-4572","observed_orcids":["https://orcid.org/0000-0003-0076-4572"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Soheir S. Adam","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. soheir.adam@duke.edu","Division of Hematology / Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. soheir.adam@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Hematology / Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001812366","display_name":"Carolyn C. Hoppe","orcid":"https://orcid.org/0000-0001-9213-0547","observed_orcids":["https://orcid.org/0000-0001-9213-0547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Hoppe","raw_affiliation_strings":["Department of Hematology/Oncology, Children's Hospital & Research Center Oakland, Oakland, California","Department of Hematology/Oncology, Children's Hospital and Research Center Oakland, Oakland, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Children's Hospital & Research Center Oakland, Oakland, California","institution_ids":[]},{"raw_affiliation_string":"Department of Hematology/Oncology, Children's Hospital and Research Center Oakland, Oakland, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011860608"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.2962,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.2749616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"4","first_page":"550","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8870000243186951},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.925000011920929},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion-molecules","display_name":"endothelial adhesion molecules","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.910241425037384},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6156842112541199},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.603856086730957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5998175740242004},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5582378506660461},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5113803744316101},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4625389575958252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4330846965312958},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38839441537857056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.366327166557312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22059813141822815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.24443","doi":"https://doi.org/10.1002/pbc.24443","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.24443","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:23281161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23281161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W40986856","https://openalex.org/W589871947","https://openalex.org/W1523363473","https://openalex.org/W1560941842","https://openalex.org/W1597507340","https://openalex.org/W1653009609","https://openalex.org/W1671726658","https://openalex.org/W1778499707","https://openalex.org/W1912923296","https://openalex.org/W1955305991","https://openalex.org/W1969621046","https://openalex.org/W1970244706","https://openalex.org/W1972168561","https://openalex.org/W1973339314","https://openalex.org/W1973610105","https://openalex.org/W1973774087","https://openalex.org/W1974910623","https://openalex.org/W1976989874","https://openalex.org/W1987967030","https://openalex.org/W1990029657","https://openalex.org/W1990033742","https://openalex.org/W1991432513","https://openalex.org/W1991618746","https://openalex.org/W1993539946","https://openalex.org/W1994628443","https://openalex.org/W2000893933","https://openalex.org/W2001682472","https://openalex.org/W2004123988","https://openalex.org/W2012026140","https://openalex.org/W2013392029","https://openalex.org/W2015960698","https://openalex.org/W2018379041","https://openalex.org/W2018975142","https://openalex.org/W2019248295","https://openalex.org/W2019422439","https://openalex.org/W2020616236","https://openalex.org/W2020846860","https://openalex.org/W2024135550","https://openalex.org/W2024437524","https://openalex.org/W2027244023","https://openalex.org/W2029642989","https://openalex.org/W2032330710","https://openalex.org/W2033347119","https://openalex.org/W2034445068","https://openalex.org/W2034998957","https://openalex.org/W2036131736","https://openalex.org/W2037526124","https://openalex.org/W2043852077","https://openalex.org/W2046100367","https://openalex.org/W2049579241","https://openalex.org/W2054274224","https://openalex.org/W2054688528","https://openalex.org/W2058505378","https://openalex.org/W2059171556","https://openalex.org/W2061654619","https://openalex.org/W2067738744","https://openalex.org/W2073233733","https://openalex.org/W2075522879","https://openalex.org/W2076110739","https://openalex.org/W2082679209","https://openalex.org/W2088746564","https://openalex.org/W2089093821","https://openalex.org/W2091146995","https://openalex.org/W2093499369","https://openalex.org/W2098307218","https://openalex.org/W2098847286","https://openalex.org/W2099355565","https://openalex.org/W2100471336","https://openalex.org/W2105187058","https://openalex.org/W2108644172","https://openalex.org/W2114995895","https://openalex.org/W2121037015","https://openalex.org/W2127825207","https://openalex.org/W2129466144","https://openalex.org/W2136727847","https://openalex.org/W2137983259","https://openalex.org/W2138220081","https://openalex.org/W2141202715","https://openalex.org/W2144896295","https://openalex.org/W2146318670","https://openalex.org/W2146325907","https://openalex.org/W2147613516","https://openalex.org/W2152789823","https://openalex.org/W2158136442","https://openalex.org/W2160152341","https://openalex.org/W2160471722","https://openalex.org/W2165755711","https://openalex.org/W2166938590","https://openalex.org/W2249491864","https://openalex.org/W2278817754","https://openalex.org/W2314490234","https://openalex.org/W2335814690","https://openalex.org/W2395132167","https://openalex.org/W2416002450","https://openalex.org/W2419366142","https://openalex.org/W2608539973","https://openalex.org/W4241694836","https://openalex.org/W4246764494","https://openalex.org/W4249969224","https://openalex.org/W4298279019"],"related_works":["https://openalex.org/W1955305991","https://openalex.org/W2567134503","https://openalex.org/W2556813579","https://openalex.org/W7095224423","https://openalex.org/W2040213541","https://openalex.org/W1979638770","https://openalex.org/W2599692870","https://openalex.org/W2991851901","https://openalex.org/W2564383645","https://openalex.org/W1981350653"],"abstract_inverted_index":{"The":[0,74],"complex":[1],"pathophysiology":[2],"of":[3,44,48,77,96],"sickle":[4],"cell":[5],"disease":[6],"(SCD)":[7],"is":[8],"remarkably":[9],"similar":[10],"to":[11,40,57],"that":[12],"observed":[13],"in":[14,98],"other":[15],"chronic":[16],"vascular":[17],"diseases":[18],"and":[19,31,61,69],"involves":[20],"multiple":[21],"biologic":[22],"pathways":[23],"triggered":[24],"by":[25],"ischemia":[26],"reperfusion":[27],"injury,":[28],"coagulation":[29],"activation,":[30],"inflammation.":[32],"Statins":[33],"are":[34],"potent":[35],"lipid-lowering":[36],"agents":[37,81],"commonly":[38],"used":[39],"reduce":[41,65],"the":[42,93],"risk":[43],"cardiovascular":[45],"disease.":[46],"Independent":[47],"their":[49],"lipid":[50],"lowering":[51],"effect,":[52],"statins":[53,78,97],"have":[54],"been":[55],"shown":[56],"down-regulate":[58],"inflammatory":[59],"mediators":[60],"endothelial":[62],"adhesion":[63],"molecules,":[64],"tissue":[66],"factor":[67],"expression":[68],"restore":[70],"nitric":[71],"oxide":[72],"bioavailability.":[73],"pleiotropic":[75],"effects":[76],"make":[79],"these":[80],"attractive":[82],"therapeutic":[83],"candidates":[84],"for":[85,92],"SCD.":[86,99],"This":[87],"article":[88],"reviews":[89],"available":[90],"evidence":[91],"potential":[94],"role":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
