{"id":"https://openalex.org/W2035545604","doi":"https://doi.org/10.1089/thy.1999.9.1167","title":"Factors Associated with Mortality of Myxedema Coma: Report of Eight Cases and Literature Survey","display_name":"Factors Associated with Mortality of Myxedema Coma: Report of Eight Cases and Literature Survey","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2035545604","doi":"https://doi.org/10.1089/thy.1999.9.1167","mag":"2035545604","pmid":"https://pubmed.ncbi.nlm.nih.gov/10646654"},"language":"en","primary_location":{"id":"doi:10.1089/thy.1999.9.1167","doi":"https://doi.org/10.1089/thy.1999.9.1167","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.1999.9.1167","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101773357","display_name":"Toshihide Yamamoto","orcid":"https://orcid.org/0000-0003-3047-4832","observed_orcids":["https://orcid.org/0000-0003-3047-4832"]},"institutions":[{"id":"https://openalex.org/I4210144700","display_name":"Kishiwada Tokushukai Hospital","ror":"https://ror.org/05gn4hz56","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210144700"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOSHIHIDE YAMAMOTO","raw_affiliation_strings":["Kishiwada Tokushukai Hospital, Osaka, Japan. Kishiwada@tokushukai.or.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kishiwada Tokushukai Hospital, Osaka, Japan. Kishiwada@tokushukai.or.jp","institution_ids":["https://openalex.org/I4210144700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024903624","display_name":"Jiro Fukuyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JIRO FUKUYAMA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054947155","display_name":"Akira Fujiyoshi","orcid":"https://orcid.org/0000-0002-5790-7119","observed_orcids":["https://orcid.org/0000-0002-5790-7119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AKIRA FUJIYOSHI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6102,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.66517728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"1167","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13533","display_name":"Medical Case Reports and Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myxedema-coma","display_name":"myxedema coma","score":1.0},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.75},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.9490000009536743},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardiac-complications","display_name":"cardiac complications","score":0.6859999895095825},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.3959999978542328},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9452451467514038},{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.7405124306678772},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5681343078613281},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4833826422691345},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4186767339706421},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.41819655895233154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36408907175064087},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3569377660751343}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009230","descriptor_name":"Myxedema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009230","descriptor_name":"Myxedema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/thy.1999.9.1167","doi":"https://doi.org/10.1089/thy.1999.9.1167","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.1999.9.1167","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},{"id":"pmid:10646654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10646654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid : official journal of the American Thyroid Association","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W29053829","https://openalex.org/W105947977","https://openalex.org/W180476138","https://openalex.org/W1902656091","https://openalex.org/W1955260519","https://openalex.org/W1984453496","https://openalex.org/W1987820130","https://openalex.org/W1996632226","https://openalex.org/W2038125257","https://openalex.org/W2040206692","https://openalex.org/W2050818700","https://openalex.org/W2051426630","https://openalex.org/W2055506652","https://openalex.org/W2056863843","https://openalex.org/W2063268750","https://openalex.org/W2071637551","https://openalex.org/W2073219927","https://openalex.org/W2086639942","https://openalex.org/W2092307452","https://openalex.org/W2093621891","https://openalex.org/W2160362597","https://openalex.org/W2163395450","https://openalex.org/W2166878339","https://openalex.org/W2399657427","https://openalex.org/W2401441004","https://openalex.org/W2402540546","https://openalex.org/W2412395353","https://openalex.org/W2413669702","https://openalex.org/W2439593846","https://openalex.org/W4237397140","https://openalex.org/W4243241800","https://openalex.org/W4252150380","https://openalex.org/W4293242440"],"related_works":["https://openalex.org/W2002783177","https://openalex.org/W2010191128","https://openalex.org/W2571711385","https://openalex.org/W2022753158","https://openalex.org/W2921593947","https://openalex.org/W2271457672","https://openalex.org/W3144348195","https://openalex.org/W2339406449","https://openalex.org/W4224312657","https://openalex.org/W4223523683"],"abstract_inverted_index":{"High-dose":[0],"thyroid":[1,25,110,154,170],"hormone":[2,26,111,155,171,206],"replacement":[3,27,112,172],"has":[4],"been":[5,30],"recommended":[6],"for":[7,104,122],"treatment":[8],"of":[9,15,17,21,23,42,52,64,71,77,109,118,146,153,196,210],"myxedema":[10],"coma":[11],"(MC)":[12],"while":[13],"questions":[14],"safety":[16],"the":[18,45,56,72,80,88,99,130],"therapy":[19],"and":[20,55,79,113,126,135,151,168],"efficacy":[22],"low-dose":[24,205],"have":[28],"not":[29],"systematically":[31],"addressed.":[32],"We":[33],"treated":[34,203],"8":[35],"patients":[36,59,75,125,200,227],"with":[37,48,60,94,107,138,189,204],"MC":[38,105,199],"in":[39,240],"a":[40,61,190],"period":[41],"18":[43],"years,":[44],"first":[46,73],"3":[47,74],"high-dose":[49,169],"intravenous":[50],"injections":[51],"levotriiodothyronine":[53],"(LT3)":[54],"other":[57,81],"5":[58,82,124],"smaller":[62],"amount":[63],"either":[65],"LT3":[66,180],"or":[67,148,175,179,182,217],"levothyroxine":[68],"(LT4).":[69],"Two":[70],"died":[76],"pneumonia":[78],"recovered":[83],"despite":[84],"pulmonary":[85,149],"abnormalities":[86],"at":[87],"outset.":[89],"To":[90],"find":[91],"factors":[92,136],"associated":[93,137,188],"fatal":[95,191],"outcome":[96,114,192],"after":[97],"treatment,":[98],"MEDLINE":[100,131],"database":[101],"was":[102],"searched":[103],"cases":[106,128],"data":[108,121],"within":[115,193],"1":[116,194],"month":[117,195],"therapy.":[119],"Clinical":[120],"our":[123],"82":[127],"from":[129],"search":[132],"were":[133,140,186],"pooled":[134],"mortality":[139],"sought":[141],"among":[142],"age,":[143,165],"gender,":[144],"presence":[145],"cardiac":[147,166,232],"complications,":[150,167],"doses":[152],"by":[156,215,225],"multiple":[157],"logistic":[158],"regression":[159],"analysis.":[160],"It":[161],"revealed":[162],"that":[163],"greater":[164],"(LT4":[173],">":[174,181],"=":[176,183],"500":[177,211],"microg/d":[178],"75":[184],"microg/d)":[185],"significantly":[187],"treatment.":[197],"Elderly":[198],"can":[201],"be":[202,223,238],"replacement.":[207],"A":[208],"bolus":[209],"microg":[212],"LT4,":[213],"especially":[214],"mouth":[216],"via":[218],"nasogastric":[219],"tube,":[220],"appears":[221],"to":[222,237],"tolerated":[224],"younger":[226],"(<":[228],"55":[229],"years)":[230],"without":[231],"complication.":[233],"The":[234],"conclusion":[235],"remains":[236],"confirmed":[239],"more":[241],"patients.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}