{"id":"https://openalex.org/W2035508902","doi":"https://doi.org/10.1016/0306-3623(91)90454-e","title":"The ability of insulin treatment to reverse or prevent the changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus","display_name":"The ability of insulin treatment to reverse or prevent the changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2035508902","doi":"https://doi.org/10.1016/0306-3623(91)90454-e","mag":"2035508902","pmid":"https://pubmed.ncbi.nlm.nih.gov/2055425"},"language":"en","primary_location":{"id":"doi:10.1016/0306-3623(91)90454-e","doi":"https://doi.org/10.1016/0306-3623(91)90454-e","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-3623(91)90454-e","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/0306-3623(91)90454-e","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112100529","display_name":"Penelope A. Longhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Penelope A. Longhurst","raw_affiliation_strings":["Division of Urology, Hospital of the University of Pennsylvania, Philadelphia 19104-4283"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Hospital of the University of Pennsylvania, Philadelphia 19104-4283","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020145640","display_name":"Jane Kauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Kauer","raw_affiliation_strings":["Division of Urology, 3010 Raydin Courtyard Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, U.S.A. [Tel. (215) 662-6660]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, 3010 Raydin Courtyard Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, U.S.A. [Tel. (215) 662-6660]","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Levin","raw_affiliation_strings":["Division of Urology, 3010 Raydin Courtyard Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, U.S.A. [Tel. (215) 662-6660]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, 3010 Raydin Courtyard Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, U.S.A. [Tel. (215) 662-6660]","institution_ids":["https://openalex.org/I2799810409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112100529"],"corresponding_institution_ids":["https://openalex.org/I2799810409"],"apc_list":null,"apc_paid":null,"fwci":8.3589,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.97884889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"2","first_page":"305","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/bladder-function","display_name":"bladder function","score":0.8029999732971191},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/micturition","display_name":"micturition","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bladder-contractility","display_name":"bladder contractility","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bethanechol","display_name":"bethanechol","score":0.6740000247955322},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.6320000290870667},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.6790000200271606},{"id":"https://openalex.org/keywords/fluid-intake","display_name":"fluid intake","score":0.5609999895095825},{"id":"https://openalex.org/keywords/diabetes-duration","display_name":"diabetes duration","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7881146669387817},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7854571342468262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6900351047515869},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5549795031547546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5016958713531494},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47942060232162476},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4632393717765808},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.4175716042518616}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001745","descriptor_name":"Urinary Bladder Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001745","descriptor_name":"Urinary Bladder Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001745","descriptor_name":"Urinary Bladder Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014563","descriptor_name":"Urodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-3623(91)90454-e","doi":"https://doi.org/10.1016/0306-3623(91)90454-e","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-3623(91)90454-e","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},{"id":"pmid:2055425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2055425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0306-3623(91)90454-e","doi":"https://doi.org/10.1016/0306-3623(91)90454-e","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-3623(91)90454-e","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G124642987","display_name":"METABOLIC REGULATION OF URINARY BLADDER FUNCTION","funder_award_id":"R01DK033559","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5634912814","display_name":"AUTONOMIC CONTROL OF LOWER URINARY TRACT FUNCTION","funder_award_id":"R01DK026508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6549909234","display_name":"URINARY BLADDER DYSFUNCTION IN DIABETES MELLITUS","funder_award_id":"R23DK036488","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W108306744","https://openalex.org/W1522815820","https://openalex.org/W1978421101","https://openalex.org/W2000859369","https://openalex.org/W2025984018","https://openalex.org/W2037143694","https://openalex.org/W2039773733","https://openalex.org/W2061672397","https://openalex.org/W2085825893","https://openalex.org/W2107701127","https://openalex.org/W2116576150","https://openalex.org/W2245454786","https://openalex.org/W2288951047","https://openalex.org/W2398421370","https://openalex.org/W2409297343","https://openalex.org/W2412858907","https://openalex.org/W2439636577","https://openalex.org/W2460777041","https://openalex.org/W4406968927"],"related_works":["https://openalex.org/W2388278809","https://openalex.org/W3098609990","https://openalex.org/W2018890179","https://openalex.org/W2003902482","https://openalex.org/W2245454786","https://openalex.org/W2424813251","https://openalex.org/W1487738463","https://openalex.org/W2416962811","https://openalex.org/W7095462609","https://openalex.org/W1968367442"],"abstract_inverted_index":{"1.":[0],"The":[1,143],"effects":[2,47,105,148],"of":[3,22,40,64,79,98,117,129,149],"insulin":[4,52,110,162],"treatment":[5,56,111,122],"on":[6,152],"in":[7,10,15,27,29,34,61,85,87,92,126],"vivo":[8],"and":[9,32,42,75,90,100,140,159],"vitro":[11],"urinary":[12,153],"bladder":[13,65,130,154],"function":[14,155],"streptozotocin-diabetic":[16],"rats":[17,70,135],"were":[18,49,107],"investigated.":[19],"2.":[20],"Diabetes":[21,78],"2":[23,115],"months":[24,81,116],"duration":[25,82],"resulted":[26,84],"decreases":[28,86],"body":[30,66,88,131],"weight":[31],"increases":[33,60,91,125],"fluid":[35,93],"consumption,":[36,94],"urine":[37,95],"volume,":[38,96],"frequency":[39,97],"micturition,":[41,99,104],"average":[43,101],"volume":[44,102],"per":[45,103],"micturition;":[46],"which":[48,106],"prevented":[50,58,158],"by":[51,109,161],"treatment.":[53,163],"3.":[54],"Insulin":[55,121],"also":[57,83],"the":[59,113,118,124,147],"contractile":[62,127],"responses":[63,128],"strips":[67,132],"from":[68,133],"diabetic":[69,134],"to":[71,136],"nerve":[72,137],"stimulation,":[73,138],"ATP,":[74,139],"bethanechol.":[76,141],"4.":[77],"4":[80],"weight,":[89],"reversed":[108,123,160],"for":[112],"final":[114],"study.":[119],"5.":[120],"6.":[142],"data":[144],"indicate":[145],"that":[146],"streptozotocin-induced":[150],"diabetes":[151],"are":[156],"both":[157]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}