{"id":"https://openalex.org/W2035500065","doi":"https://doi.org/10.1159/000098620","title":"Neurotransplantation in Parkinson's Disease: From Open Microsurgery to Bilateral Stereotactic Approach: First Clinical Trial Using Microelectrode Recording Technique","display_name":"Neurotransplantation in Parkinson's Disease: From Open Microsurgery to Bilateral Stereotactic Approach: First Clinical Trial Using Microelectrode Recording Technique","publication_year":1995,"publication_date":"1995-04-11","ids":{"openalex":"https://openalex.org/W2035500065","doi":"https://doi.org/10.1159/000098620","mag":"2035500065","pmid":"https://pubmed.ncbi.nlm.nih.gov/7631069"},"language":"en","primary_location":{"id":"doi:10.1159/000098620","doi":"https://doi.org/10.1159/000098620","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000098620","pdf_url":null,"source":{"id":"https://openalex.org/S115742856","display_name":"Stereotactic and Functional Neurosurgery","issn_l":"1011-6125","issn":["1011-6125","1423-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and Functional Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065198190","display_name":"H. Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"H. Molina","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014099365","display_name":"R.Q. Qui\u00f1ones-Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"R. Qui\u00f1ones-Molina","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542564","display_name":"J. Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"J. Mu\u00f1oz","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520738","display_name":"L. Alvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"L. Alvarez","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066939712","display_name":"A. Alaminos","orcid":"https://orcid.org/0000-0002-9216-4357","observed_orcids":["https://orcid.org/0000-0002-9216-4357"]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"A. Alaminos","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046339268","display_name":"I. Ortega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"I. Ortega","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081840581","display_name":"Ch. Ohye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ch. Ohye","raw_affiliation_strings":["Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Mac\u00edas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"R. Mac\u00edas","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114049825","display_name":"J. Piedra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"J. Piedra","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"C. Gonz\u00e1lez","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Cu\u00e9tara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"K. Cu\u00e9tara","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"A. Torres","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F. Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"F. Morales","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Teijeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"J. Teijeiro","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"O. Torres","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Leon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"M. Leon","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"last","author":{"id":null,"display_name":"M. Rojas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"M. Rojas","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, C. Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.297,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.57862462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"62","issue":"1-4","first_page":"204","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.17090000212192535,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microelectrode-recording","display_name":"microelectrode recording","score":0.8899999856948853},{"id":"https://openalex.org/keywords/levodopa-induced-dyskinesia","display_name":"levodopa-induced dyskinesia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.6990000009536743},{"id":"https://openalex.org/keywords/off-periods","display_name":"off periods","score":0.6140000224113464},{"id":"https://openalex.org/keywords/caudate-and-putamen","display_name":"caudate and putamen","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2781437307","wikidata":"https://www.wikidata.org/wiki/Q977628","display_name":"Microsurgery","level":2,"score":0.7118608355522156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6637393832206726},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49588093161582947},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.4575570821762085},{"id":"https://openalex.org/C2779634917","wikidata":"https://www.wikidata.org/wiki/Q1931968","display_name":"Stereotactic surgery","level":2,"score":0.4487638473510742},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3632795214653015},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3026115894317627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10953539609909058},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007839","descriptor_name":"Functional Laterality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008866","descriptor_name":"Microsurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013238","descriptor_name":"Stereotaxic Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D013813","descriptor_name":"Therapy, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014743","descriptor_name":"Videotape Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016332","descriptor_name":"Fetal Tissue Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000098620","doi":"https://doi.org/10.1159/000098620","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000098620","pdf_url":null,"source":{"id":"https://openalex.org/S115742856","display_name":"Stereotactic and Functional Neurosurgery","issn_l":"1011-6125","issn":["1011-6125","1423-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and Functional Neurosurgery","raw_type":"journal-article"},{"id":"pmid:7631069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7631069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and functional neurosurgery","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W46476993","https://openalex.org/W2074126660","https://openalex.org/W2008001474","https://openalex.org/W2336655391","https://openalex.org/W2410333895","https://openalex.org/W2116246431","https://openalex.org/W2443925991","https://openalex.org/W6987699426","https://openalex.org/W2410332145","https://openalex.org/W2038272859"],"abstract_inverted_index":{"This":[0],"paper":[1],"summarizes":[2],"the":[3,12,20,52,59,77,107,112,116,127,152,155,162,167],"results":[4],"of":[5,14,22,81,105,118,126,154],"three":[6],"controlled":[7],"clinical":[8],"trials":[9],"related":[10],"to":[11,37,144,173],"transplantation":[13,101],"embryonic":[15],"ventral":[16],"mesencephalic":[17,67],"tissue":[18,49],"into":[19,76],"striatum":[21],"46":[23],"idiopathic":[24],"parkinsonian":[25,82],"patients":[26,83],"exhibiting":[27],"motor":[28,128],"complications":[29],"on":[30],"standard":[31],"levodopa":[32],"therapy.":[33],"From":[34],"January":[35,140],"1988":[36],"April":[38],"1990,":[39],"30":[40],"subjects":[41],"with":[42,84,134],"fluctuating":[43],"Parkinson's":[44,160],"disease":[45],"received":[46],"fetal":[47,66],"dopaminergic":[48],"implants":[50],"by":[51],"open":[53],"microsurgical":[54],"technique.":[55],"In":[56,171],"March":[57],"1992":[58],"stereotactic":[60,131],"approach":[61],"was":[62,137],"adopted":[63],"for":[64,180],"successive":[65],"cell":[68],"suspension":[69],"transplants":[70],"(7":[71],"unilateral":[72],"and":[73,79,88,97,115,122,166,184],"9":[74],"bilateral)":[75],"caudate":[78],"putamen":[80],"levodopa-induced":[85],"complex":[86],"fluctuations":[87],"dyskinesias.":[89],"The":[90,130],"neurological":[91],"assessment":[92],"performed":[93],"12":[94],"months":[95,99],"before":[96],"3-18":[98],"after":[100],"demonstrated":[102],"a":[103,123,146],"reduction":[104],"both":[106],"daily":[108,119],"time":[109],"spent":[110],"in":[111,139,142,159],"'off'":[113,120],"condition":[114],"number":[117],"periods,":[121],"significant":[124],"improvement":[125],"scale.":[129],"selective":[132,168],"thalamotomy":[133],"microelectrode":[135,175],"recording":[136,176],"introduced":[138],"1993,":[141],"order":[143],"provide":[145],"further":[147],"potential":[148],"treatment":[149],"strategy;":[150],"i.e.,":[151],"combination":[153],"two":[156],"surgical":[157],"trends":[158],"disease,":[161],"restorative":[163],"neurotransplantation":[164],"technique,":[165],"lesional":[169],"approach.":[170],"addition":[172],"that,":[174],"is":[177],"also":[178],"used":[179],"implantation":[181],"site":[182],"selection":[183],"functional":[185],"characterization.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}