{"id":"https://openalex.org/W2035467136","doi":"https://doi.org/10.1074/jbc.m609384200","title":"A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling","display_name":"A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling","publication_year":2006,"publication_date":"2006-10-25","ids":{"openalex":"https://openalex.org/W2035467136","doi":"https://doi.org/10.1074/jbc.m609384200","mag":"2035467136","pmid":"https://pubmed.ncbi.nlm.nih.gov/17062560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3680705"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m609384200","doi":"https://doi.org/10.1074/jbc.m609384200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609384200","pdf_url":"http://www.jbc.org/article/S0021925819338359/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819338359/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111878415","display_name":"Sadaf\u2010Ahmahni Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sadaf-Ahmahni Hussain","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London, UK","Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086214764","display_name":"Michael Piper","orcid":"https://orcid.org/0000-0002-6759-2560","observed_orcids":["https://orcid.org/0000-0002-6759-2560"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Piper","raw_affiliation_strings":["Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083390737","display_name":"N. Fukuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"No\u00e9mi Fukuhara","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041522364","display_name":"Laure Strochlic","orcid":"https://orcid.org/0000-0001-5373-4284","observed_orcids":["https://orcid.org/0000-0001-5373-4284"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laure Strochlic","raw_affiliation_strings":["Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079317218","display_name":"Gian Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gian Cho","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028177758","display_name":"Jason A. Howitt","orcid":"https://orcid.org/0000-0001-9922-7931","observed_orcids":["https://orcid.org/0000-0001-9922-7931"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason A. Howitt","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022000919","display_name":"Yassir Ahmed","orcid":"https://orcid.org/0000-0002-0106-1724","observed_orcids":["https://orcid.org/0000-0002-0106-1724"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yassir Ahmed","raw_affiliation_strings":["Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069868342","display_name":"Andrew K. Powell","orcid":"https://orcid.org/0000-0002-3680-9384","observed_orcids":["https://orcid.org/0000-0002-3680-9384"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew K. Powell","raw_affiliation_strings":["Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013218544","display_name":"Jeremy E. Turnbull","orcid":"https://orcid.org/0000-0002-1791-754X","observed_orcids":["https://orcid.org/0000-0002-1791-754X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy E. Turnbull","raw_affiliation_strings":["Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Glycobiology Group, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079094223","display_name":"Christine E. Holt","orcid":"https://orcid.org/0000-0003-2829-121X","observed_orcids":["https://orcid.org/0000-0003-2829-121X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christine E. Holt","raw_affiliation_strings":["Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018180229","display_name":"Erhard Hohenester","orcid":"https://orcid.org/0000-0002-0813-7218","observed_orcids":["https://orcid.org/0000-0002-0813-7218"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Erhard Hohenester","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018180229"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.6711,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.89831671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"281","issue":"51","first_page":"39693","last_page":"39698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slit-robo-signaling","display_name":"Slit-Robo signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.9670000076293945},{"id":"https://openalex.org/keywords/heparin-binding","display_name":"heparin binding","score":0.8899999856948853},{"id":"https://openalex.org/keywords/robo-receptors","display_name":"Robo receptors","score":0.9449999928474426},{"id":"https://openalex.org/keywords/guidance-cues","display_name":"guidance cues","score":0.4779999852180481},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-surface-proteoglycans","display_name":"cell surface proteoglycans","score":0.6830000281333923},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C199215989","wikidata":"https://www.wikidata.org/wiki/Q79239196","display_name":"Slit","level":2,"score":0.9208247661590576},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.719290018081665},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.5635604858398438},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5341125130653381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5228527188301086},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49223199486732483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48747968673706055},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.46205440163612366},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.42131465673446655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4210963249206543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36614739894866943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3551349639892578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14015203714370728}],"mesh":[{"descriptor_ui":"D000097905","descriptor_name":"Roundabout Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020439","descriptor_name":"Growth Cones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020439","descriptor_name":"Growth Cones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m609384200","doi":"https://doi.org/10.1074/jbc.m609384200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609384200","pdf_url":"http://www.jbc.org/article/S0021925819338359/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17062560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17062560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2677718","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3680705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3680705","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3680705/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m609384200","doi":"https://doi.org/10.1074/jbc.m609384200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609384200","pdf_url":"http://www.jbc.org/article/S0021925819338359/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4884333268","display_name":"Axon navigation in the developing brain.","funder_award_id":"070568","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6721348343","display_name":"Structural studies of extracellular matrix proteins and their receptors in development and disease.","funder_award_id":"054334","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8527216501","display_name":"Structural studies of Slit-Robo interactions in axon guidance.","funder_award_id":"067203","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035467136.pdf","grobid_xml":"https://content.openalex.org/works/W2035467136.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W656365412","https://openalex.org/W1547580946","https://openalex.org/W1941583860","https://openalex.org/W1967243994","https://openalex.org/W1974873948","https://openalex.org/W1975601614","https://openalex.org/W1988176449","https://openalex.org/W1993608710","https://openalex.org/W1998510940","https://openalex.org/W2005215351","https://openalex.org/W2006641366","https://openalex.org/W2006696021","https://openalex.org/W2010084732","https://openalex.org/W2025065524","https://openalex.org/W2030155901","https://openalex.org/W2033712349","https://openalex.org/W2047112279","https://openalex.org/W2050256171","https://openalex.org/W2054445281","https://openalex.org/W2065826412","https://openalex.org/W2067999962","https://openalex.org/W2068555773","https://openalex.org/W2069262666","https://openalex.org/W2069935884","https://openalex.org/W2082761841","https://openalex.org/W2085716177","https://openalex.org/W2087086162","https://openalex.org/W2122965729","https://openalex.org/W2142226955","https://openalex.org/W2154273966","https://openalex.org/W2163557331","https://openalex.org/W2169737891"],"related_works":["https://openalex.org/W2093160853","https://openalex.org/W2130500578","https://openalex.org/W7100905191","https://openalex.org/W6943996067","https://openalex.org/W2143652911","https://openalex.org/W7099985538","https://openalex.org/W2483467359","https://openalex.org/W1969875830","https://openalex.org/W2158873473","https://openalex.org/W1547580946"],"abstract_inverted_index":{"Slit":[0,22,94,117,138],"is":[1,39,151],"a":[2,61,68,84,98,103,108],"large":[3],"secreted":[4],"protein":[5],"that":[6,44,93,149],"provides":[7],"important":[8,63],"guidance":[9],"cues":[10],"in":[11,17,83,132],"the":[12,45,77,80,133,156,165],"developing":[13],"nervous":[14],"system":[15],"and":[16,29,102,143,161],"other":[18],"organs.":[19],"Signaling":[20],"by":[21,116],"requires":[23,119],"two":[24],"receptors,":[25,58],"Robo":[26,57,100],"transmembrane":[27],"proteins":[28],"heparan":[30],"sulfate":[31],"(HS)":[32],"proteoglycans.":[33],"How":[34],"HS":[35,122],"controls":[36],"Slit-Robo":[37,81,158,168],"signaling":[38,159],"unclear.":[40],"Here":[41],"we":[42],"show":[43],"second":[46],"leucine-rich":[47],"repeat":[48],"domain":[49],"(D2)":[50],"of":[51,72,79,128,137,155],"Slit,":[52],"which":[53],"mediates":[54],"binding":[55,64,86,142],"to":[56,106,163],"also":[59],"contains":[60],"functionally":[62],"site":[65],"for":[66],"heparin,":[67],"highly":[69],"sulfated":[70],"variant":[71],"HS.":[73],"Heparin":[74],"markedly":[75],"enhances":[76],"affinity":[78],"interaction":[82],"solid-phase":[85],"assay.":[87],"Analytical":[88],"gel":[89],"filtration":[90],"chromatography":[91],"demonstrates":[92],"D2":[95,118,139],"associates":[96],"with":[97],"soluble":[99],"fragment":[101],"heparin-derived":[104],"oligosaccharide":[105],"form":[107],"ternary":[109],"complex.":[110],"Retinal":[111],"growth":[112],"cone":[113],"collapse":[114],"triggered":[115],"cell":[120],"surface":[121],"or":[123],"exogenously":[124],"added":[125],"heparin.":[126],"Mutation":[127],"conserved":[129],"basic":[130],"residues":[131],"C-terminal":[134],"cap":[135],"region":[136],"reduces":[140],"heparin":[141],"abolishes":[144],"biological":[145],"activity.":[146],"We":[147],"conclude":[148],"heparin/HS":[150],"an":[152],"integral":[153],"component":[154],"minimal":[157],"complex":[160],"serves":[162],"stabilize":[164],"relatively":[166],"weak":[167],"interaction.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
