{"id":"https://openalex.org/W2035455587","doi":"https://doi.org/10.1021/jm00052a014","title":"Pentamidine Congeners. 2. 2-Butene-Bridged Aromatic Diamidines and Diimidazolines as Potential Anti-Pneumocystis carinii Pneumonia Agents","display_name":"Pentamidine Congeners. 2. 2-Butene-Bridged Aromatic Diamidines and Diimidazolines as Potential Anti-Pneumocystis carinii Pneumonia Agents","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W2035455587","doi":"https://doi.org/10.1021/jm00052a014","mag":"2035455587","pmid":"https://pubmed.ncbi.nlm.nih.gov/7799405"},"language":"en","primary_location":{"id":"doi:10.1021/jm00052a014","doi":"https://doi.org/10.1021/jm00052a014","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00052a014","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111080596","display_name":"Isaac O. Donkor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isaac O. Donkor","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163","Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee-Memphis 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee-Memphis 38163","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080123057","display_name":"Richard R. Tidwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R. Tidwell","raw_affiliation_strings":["University of North Carolina","University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]},{"raw_affiliation_string":"University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052939278","display_name":"Susan Jones","orcid":"https://orcid.org/0000-0003-0883-4627","observed_orcids":["https://orcid.org/0000-0003-0883-4627"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan K. Jones","raw_affiliation_strings":["University of North Carolina","University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]},{"raw_affiliation_string":"University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.6895,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92657718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"37","issue":"26","first_page":"4554","last_page":"4557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cis-trans-isomers","display_name":"cis-trans isomers","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cis-trans-isomerism","display_name":"cis-trans isomerism","score":0.6669999957084656},{"id":"https://openalex.org/keywords/methoxy-substituent-effects","display_name":"methoxy substituent effects","score":0.7929999828338623},{"id":"https://openalex.org/keywords/host-toxicity","display_name":"host toxicity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.902999997138977},{"id":"https://openalex.org/keywords/poly-da-poly-dt","display_name":"poly(dA).poly(dT)","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2993443204","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis carinii","level":4,"score":0.9741577506065369},{"id":"https://openalex.org/C2777530519","wikidata":"https://www.wikidata.org/wiki/Q416206","display_name":"Pentamidine","level":3,"score":0.950255274772644},{"id":"https://openalex.org/C2778622868","wikidata":"https://www.wikidata.org/wiki/Q423088","display_name":"Amidine","level":2,"score":0.807151198387146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7956661581993103},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6122825145721436},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5651820302009583},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5161705613136292},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.491195410490036},{"id":"https://openalex.org/C2777040443","wikidata":"https://www.wikidata.org/wiki/Q412265","display_name":"Diphenylamine","level":2,"score":0.47102269530296326},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.42382362484931946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31898069381713867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2426852285861969},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13407158851623535},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00052a014","doi":"https://doi.org/10.1021/jm00052a014","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00052a014","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:7799405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7799405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974763592","https://openalex.org/W2120153625","https://openalex.org/W1992219001","https://openalex.org/W2033752481","https://openalex.org/W1986640522","https://openalex.org/W2054009874","https://openalex.org/W2038394366","https://openalex.org/W2157094125","https://openalex.org/W2075023295","https://openalex.org/W2036515598"],"abstract_inverted_index":{"We":[0],"have":[1],"synthesized":[2],"cis":[3,93],"and":[4,67,96,108],"trans":[5,105],"geometric":[6],"isomers":[7],"1-8":[8],"as":[9,54,77],"semirigid":[10],"congeners":[11],"of":[12,40,50,129],"pentamidine.":[13],"Compounds":[14,73],"1-4":[15,74],"were":[16,75],"more":[17],"potent":[18],"than":[19,87,103],"pentamidine":[20],"in":[21,26,55,60,112,120,124],"treating":[22],"Pneumocystis":[23],"carinii":[24,65,127],"pneumonia":[25],"immunosuppressed":[27],"rats.":[28],"These":[29,80],"compounds":[30,56,61,81],"also":[31],"demonstrated":[32,98],"no":[33],"clinical":[34],"toxicity":[35,69],"or":[36,47],"histopathologic":[37],"abnormalities.":[38],"Introduction":[39],"methoxy":[41],"substituents":[42],"meta":[43],"to":[44,70],"the":[45,51,71,125],"amidine":[46],"imidazoline":[48],"groups":[49],"phenyl":[52],"rings":[53],"5-8":[57],"generally":[58],"resulted":[59],"with":[62],"decreased":[63],"anti-P.":[64,126],"activity":[66,128],"increased":[68],"host.":[72],"evaluated":[76],"DNA":[78,102,113],"binders.":[79],"showed":[82],"greater":[83,99],"affinity":[84,100],"for":[85,88,101],"poly(dA).poly(dT)":[86],"calf":[89],"thymus":[90],"DNA.":[91],"The":[92],"isomers,":[94],"1":[95],"2,":[97],"their":[104],"counterparts":[106],"3":[107],"4.":[109],"This":[110],"difference":[111,123],"binding":[114],"affinity,":[115],"however,":[116],"did":[117],"not":[118],"reflect":[119],"a":[121],"corresponding":[122],"these":[130],"compounds.":[131]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}