{"id":"https://openalex.org/W2035447028","doi":"https://doi.org/10.1016/j.niox.2014.09.042","title":"Interfacial residues promote an optimal alignment of the catalytic center in soluble guanylate cyclase","display_name":"Interfacial residues promote an optimal alignment of the catalytic center in soluble guanylate cyclase","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2035447028","doi":"https://doi.org/10.1016/j.niox.2014.09.042","mag":"2035447028"},"language":"en","primary_location":{"id":"doi:10.1016/j.niox.2014.09.042","doi":"https://doi.org/10.1016/j.niox.2014.09.042","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.niox.2014.09.042","pdf_url":null,"source":{"id":"https://openalex.org/S152998702","display_name":"Nitric Oxide","issn_l":"1089-8603","issn":["1089-8603","1089-8611"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nitric Oxide","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051746013","display_name":"Elsa D. Garcin","orcid":"https://orcid.org/0000-0003-0501-8421","observed_orcids":["https://orcid.org/0000-0003-0501-8421"]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elsa Garcin","raw_affiliation_strings":["\u00a0 University of Maryland, Baltimore County"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a0 University of Maryland, Baltimore County","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049261929","display_name":"Franziska Seeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franziska Seeger","raw_affiliation_strings":["UMBC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMBC","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025412498","display_name":"Royston S. Quintyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Royston Quintyn","raw_affiliation_strings":["Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036268167","display_name":"Akiko Tanimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Tanimoto","raw_affiliation_strings":["Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gareth Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth Williams","raw_affiliation_strings":["Lawrence Berkeley Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley Laboratory","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059713279","display_name":"John A. Tainer","orcid":"https://orcid.org/0000-0003-1659-2429","observed_orcids":["https://orcid.org/0000-0003-1659-2429"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Tainer","raw_affiliation_strings":["TSRI/LBL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TSRI/LBL","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054298903","display_name":"Vicki Hopper Wysocki","orcid":"https://orcid.org/0000-0003-0495-2538","observed_orcids":["https://orcid.org/0000-0003-0495-2538"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicki Wysocki","raw_affiliation_strings":["Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051746013"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09918792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":null,"first_page":"112","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.30300000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.30300000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interfacial-residues","display_name":"interfacial residues","score":0.8420000076293945},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5049999952316284},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.6420000195503235},{"id":"https://openalex.org/keywords/protein-ligand-interface","display_name":"protein-ligand interface","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C27093228","wikidata":"https://www.wikidata.org/wiki/Q18026679","display_name":"GUCY1A3","level":5,"score":0.8308054804801941},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.752906084060669},{"id":"https://openalex.org/C117644","wikidata":"https://www.wikidata.org/wiki/Q18026682","display_name":"GUCY1B3","level":5,"score":0.7521148324012756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6281321048736572},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5324704647064209},{"id":"https://openalex.org/C13121076","wikidata":"https://www.wikidata.org/wiki/Q1552797","display_name":"Guanylate cyclase 2C","level":4,"score":0.5011546611785889},{"id":"https://openalex.org/C2779463800","wikidata":"https://www.wikidata.org/wiki/Q5062222","display_name":"Center (category theory)","level":2,"score":0.49393230676651},{"id":"https://openalex.org/C2778861492","wikidata":"https://www.wikidata.org/wiki/Q16825190","display_name":"Active center","level":3,"score":0.43270447850227356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35411784052848816},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26383736729621887},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.0796370804309845}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.niox.2014.09.042","doi":"https://doi.org/10.1016/j.niox.2014.09.042","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.niox.2014.09.042","pdf_url":null,"source":{"id":"https://openalex.org/S152998702","display_name":"Nitric Oxide","issn_l":"1089-8603","issn":["1089-8603","1089-8611"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nitric Oxide","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083571471","https://openalex.org/W7052688617","https://openalex.org/W2924567068","https://openalex.org/W2031631042","https://openalex.org/W1975290904","https://openalex.org/W2327372700","https://openalex.org/W2415605729","https://openalex.org/W2086334305","https://openalex.org/W2976826480","https://openalex.org/W35137439"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}