{"id":"https://openalex.org/W2035376641","doi":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","title":"Intravenous propofol anaesthesia using a computerised infusion system","display_name":"Intravenous propofol anaesthesia using a computerised infusion system","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W2035376641","doi":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","mag":"2035376641","pmid":"https://pubmed.ncbi.nlm.nih.gov/1872442"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2044.1991.tb09381.x","doi":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1991.tb09381.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1991.tb09381.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114005970","display_name":"Gavin N. C. Kenny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G.N.C. Kenny","raw_affiliation_strings":["Royal Infirmary, Glasgow G31 2ER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Infirmary, Glasgow G31 2ER","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"last","author":{"id":null,"display_name":"M. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. White","raw_affiliation_strings":["Royal Infirmary, Glasgow G31 2ER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Infirmary, Glasgow G31 2ER","institution_ids":["https://openalex.org/I2800666604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800666604"],"apc_list":{"value":4970,"currency":"USD","value_usd":4970},"apc_paid":null,"fwci":13.2653,"has_fulltext":true,"cited_by_count":146,"citation_normalized_percentile":{"value":0.99328615,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"2","first_page":"156","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14189","display_name":"Intravenous Infusion Technology and Safety","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/total-intravenous-anesthesia","display_name":"total intravenous anesthesia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.6980000138282776},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.7620000243186951},{"id":"https://openalex.org/keywords/general-surgery","display_name":"general surgery","score":0.621999979019165},{"id":"https://openalex.org/keywords/intermittent-positive-pressure-ventilation","display_name":"intermittent positive pressure ventilation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/spontaneous-breathing","display_name":"spontaneous breathing","score":0.6420000195503235},{"id":"https://openalex.org/keywords/drug-concentration-prediction","display_name":"drug concentration prediction","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7827588319778442},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.7039105296134949},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.5537397861480713},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.5094497799873352},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.336845338344574},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3284684419631958},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12932464480400085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000771","descriptor_name":"Anesthesia, Intravenous","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2044.1991.tb09381.x","doi":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1991.tb09381.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},{"id":"pmid:1872442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1872442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Letter"},{"id":"pmid:2334031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2334031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2044.1991.tb09381.x","doi":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1991.tb09381.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1991.tb09381.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035376641.pdf","grobid_xml":"https://content.openalex.org/works/W2035376641.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1573203900","https://openalex.org/W1846667020","https://openalex.org/W1996133439","https://openalex.org/W2008502740","https://openalex.org/W2015795623","https://openalex.org/W2041590182","https://openalex.org/W2072177751","https://openalex.org/W2127657911","https://openalex.org/W2141013910","https://openalex.org/W2158754438","https://openalex.org/W2398988614","https://openalex.org/W2465692541"],"related_works":["https://openalex.org/W1987846966","https://openalex.org/W1996133439","https://openalex.org/W2286544698","https://openalex.org/W2117195462","https://openalex.org/W4402610240","https://openalex.org/W2126155630","https://openalex.org/W2064185260","https://openalex.org/W1983861360","https://openalex.org/W2008643764","https://openalex.org/W2114849744"],"abstract_inverted_index":{"Propofol":[0],"offers":[1],"many":[2],"advantages":[3],"as":[4],"a":[5,40,52],"total":[6],"intravenous":[7],"anaesthetic":[8],"agent":[9],"compared":[10],"with":[11],"other":[12],"agents.":[13],"However,":[14],"considerable":[15],"experience":[16],"is":[17],"necessary":[18],"in":[19,104],"order":[20],"to":[21,48,59,68],"give":[22],"an":[23],"uncomplicated":[24],"anaesthetic.":[25],"A":[26,80],"mathematical":[27],"model":[28],"which":[29,44],"describes":[30],"the":[31,35,46,92],"pharmacokinetic":[32],"behaviour":[33],"of":[34,56],"drug":[36],"was":[37,66,84],"incorporated":[38],"into":[39],"computerised":[41],"delivery":[42],"system":[43,65],"enables":[45],"anaesthetist":[47],"achieve":[49],"and":[50,58,91,119],"maintain":[51],"target":[53],"blood":[54,88],"concentration":[55],"propofol":[57,89],"manipulate":[60],"this":[61,105],"at":[62],"will.":[63],"The":[64],"used":[67],"provide":[69],"general":[70,78],"anaesthesia":[71],"for":[72],"33":[73],"healthy":[74],"patients":[75,110],"who":[76,111,121],"underwent":[77],"surgery.":[79],"strong":[81],"statistical":[82],"relationship":[83,106],"found":[85,108],"between":[86,109],"measured":[87],"concentrations":[90],"corresponding":[93],"computer":[94],"predictions":[95],"(y":[96,114,127],"=":[97,115,128],"-0.50":[98],"+":[99,117,130],"1.36x).":[100],"No":[101],"significant":[102],"differences":[103],"were":[107],"breathed":[112],"spontaneously":[113],"-0.71x":[116],"1.43x)":[118],"those":[120],"received":[122],"intermittent":[123],"positive":[124],"pressure":[125],"ventilation":[126],"-0.33":[129],"1.32x).":[131]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}