{"id":"https://openalex.org/W2035371806","doi":"https://doi.org/10.1293/tox.20.77","title":"Nitric Oxide and Cancer Development","display_name":"Nitric Oxide and Cancer Development","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2035371806","doi":"https://doi.org/10.1293/tox.20.77","mag":"2035371806"},"language":"en","primary_location":{"id":"doi:10.1293/tox.20.77","doi":"https://doi.org/10.1293/tox.20.77","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.20.77","pdf_url":"https://www.jstage.jst.go.jp/article/tox/20/2/20_2_77/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tox/20/2/20_2_77/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center","Oklahoma Medical Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032653641","display_name":"Yashige Kotake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yashige Kotake","raw_affiliation_strings":["Oklahoma Medical Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073331119","display_name":"Rheal A. Towner","orcid":"https://orcid.org/0000-0001-7368-8983","observed_orcids":["https://orcid.org/0000-0001-7368-8983"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rheal A. Towner","raw_affiliation_strings":["Oklahoma Medical Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058093329","display_name":"We-Xing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"We-Xing Guo","raw_affiliation_strings":["Oklahoma Medical Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025745676","display_name":"Dai Nakae","orcid":"https://orcid.org/0000-0001-5895-3830","observed_orcids":["https://orcid.org/0000-0001-5895-3830"]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]},{"id":"https://openalex.org/I4210099527","display_name":"Tokyo Metropolitan Institute of Public Health","ror":"https://ror.org/00w1zvy92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210099527"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai Nakae","raw_affiliation_strings":["Tokyo Metropolitan Institute of Public Health","Tokyo University of Agriculture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Institute of Public Health","institution_ids":["https://openalex.org/I4210099527"]},{"raw_affiliation_string":"Tokyo University of Agriculture","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111820781","display_name":"Yoichi Konishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoichi Konishi","raw_affiliation_strings":["International Federation of Societies of Toxicologic Pathologists"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Federation of Societies of Toxicologic Pathologists","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3956,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78723147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"77","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9049999713897705},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.968999981880188},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ogg1","display_name":"OGG1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8420000076293945},{"id":"https://openalex.org/keywords/methionine-adenosyltransferase","display_name":"methionine adenosyltransferase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/adenosylmethionine","display_name":"adenosylmethionine","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dna-mutations","display_name":"DNA mutations","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6444980502128601},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5555875897407532},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5418028235435486},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5412530303001404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48022112250328064},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46851491928100586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46182116866111755},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.44964537024497986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44712740182876587},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.42632508277893066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3526490330696106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2939140498638153},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23046785593032837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12509992718696594},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.07831448316574097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1293/tox.20.77","doi":"https://doi.org/10.1293/tox.20.77","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.20.77","pdf_url":"https://www.jstage.jst.go.jp/article/tox/20/2/20_2_77/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1293/tox.20.77","doi":"https://doi.org/10.1293/tox.20.77","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.20.77","pdf_url":"https://www.jstage.jst.go.jp/article/tox/20/2/20_2_77/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"},{"id":"https://openalex.org/F4320327762","display_name":"Japan Food Chemical Research Foundation","ror":"https://ror.org/039wkaa17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035371806.pdf","grobid_xml":"https://content.openalex.org/works/W2035371806.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W73794745","https://openalex.org/W143623266","https://openalex.org/W174805935","https://openalex.org/W198097152","https://openalex.org/W1487052925","https://openalex.org/W1488173460","https://openalex.org/W1488493608","https://openalex.org/W1507841416","https://openalex.org/W1538545565","https://openalex.org/W1560524291","https://openalex.org/W1565012681","https://openalex.org/W1583052190","https://openalex.org/W1588425240","https://openalex.org/W1593692115","https://openalex.org/W1594268419","https://openalex.org/W1607494622","https://openalex.org/W1617191665","https://openalex.org/W1837660224","https://openalex.org/W1844185706","https://openalex.org/W1870025411","https://openalex.org/W1936054911","https://openalex.org/W1952735225","https://openalex.org/W1955547739","https://openalex.org/W1964935829","https://openalex.org/W1965097080","https://openalex.org/W1966849581","https://openalex.org/W1967132242","https://openalex.org/W1968826518","https://openalex.org/W1970449040","https://openalex.org/W1972415066","https://openalex.org/W1973115046","https://openalex.org/W1973401456","https://openalex.org/W1975043122","https://openalex.org/W1976887945","https://openalex.org/W1976981858","https://openalex.org/W1979012323","https://openalex.org/W1979388174","https://openalex.org/W1983880247","https://openalex.org/W1983974200","https://openalex.org/W1984135951","https://openalex.org/W1986776963","https://openalex.org/W1988461310","https://openalex.org/W1988801216","https://openalex.org/W1992694192","https://openalex.org/W1993987368","https://openalex.org/W1994094908","https://openalex.org/W1994389040","https://openalex.org/W1994837448","https://openalex.org/W1996672418","https://openalex.org/W1997332857","https://openalex.org/W1998038367","https://openalex.org/W1998052180","https://openalex.org/W2000780971","https://openalex.org/W2001581515","https://openalex.org/W2003971447","https://openalex.org/W2004879262","https://openalex.org/W2005278329","https://openalex.org/W2006641024","https://openalex.org/W2007737411","https://openalex.org/W2008448580","https://openalex.org/W2008748288","https://openalex.org/W2011625357","https://openalex.org/W2011776951","https://openalex.org/W2012901811","https://openalex.org/W2013328489","https://openalex.org/W2015783063","https://openalex.org/W2018404966","https://openalex.org/W2018935928","https://openalex.org/W2019752563","https://openalex.org/W2020891498","https://openalex.org/W2021163501","https://openalex.org/W2021346058","https://openalex.org/W2022595505","https://openalex.org/W2024306318","https://openalex.org/W2025106039","https://openalex.org/W2026207397","https://openalex.org/W2028316654","https://openalex.org/W2029219396","https://openalex.org/W2029411685","https://openalex.org/W2030105653","https://openalex.org/W2030573603","https://openalex.org/W2031084249","https://openalex.org/W2031365339","https://openalex.org/W2032445137","https://openalex.org/W2033019269","https://openalex.org/W2033062161","https://openalex.org/W2037075775","https://openalex.org/W2037551696","https://openalex.org/W2041033997","https://openalex.org/W2042961772","https://openalex.org/W2043415570","https://openalex.org/W2048101787","https://openalex.org/W2048240260","https://openalex.org/W2049046201","https://openalex.org/W2049740690","https://openalex.org/W2049767638","https://openalex.org/W2049876383","https://openalex.org/W2050054971","https://openalex.org/W2051430097","https://openalex.org/W2051746356","https://openalex.org/W2052689575","https://openalex.org/W2052781542","https://openalex.org/W2053693562","https://openalex.org/W2055147450","https://openalex.org/W2055354965","https://openalex.org/W2057025197","https://openalex.org/W2057059727","https://openalex.org/W2059349192","https://openalex.org/W2062289394","https://openalex.org/W2062445457","https://openalex.org/W2063078080","https://openalex.org/W2063650074","https://openalex.org/W2064874096","https://openalex.org/W2065431785","https://openalex.org/W2066849422","https://openalex.org/W2068345721","https://openalex.org/W2069720095","https://openalex.org/W2070069178","https://openalex.org/W2071367819","https://openalex.org/W2074967054","https://openalex.org/W2075712201","https://openalex.org/W2076304231","https://openalex.org/W2082424920","https://openalex.org/W2083038958","https://openalex.org/W2084198174","https://openalex.org/W2085343899","https://openalex.org/W2086948980","https://openalex.org/W2090046344","https://openalex.org/W2092145002","https://openalex.org/W2092184603","https://openalex.org/W2096324550","https://openalex.org/W2097767970","https://openalex.org/W2101734234","https://openalex.org/W2103983480","https://openalex.org/W2104944130","https://openalex.org/W2109413027","https://openalex.org/W2109523254","https://openalex.org/W2109677325","https://openalex.org/W2111681808","https://openalex.org/W2111752734","https://openalex.org/W2112853026","https://openalex.org/W2113462457","https://openalex.org/W2115446921","https://openalex.org/W2118294469","https://openalex.org/W2119369177","https://openalex.org/W2121371218","https://openalex.org/W2122886873","https://openalex.org/W2123582755","https://openalex.org/W2127102352","https://openalex.org/W2127281349","https://openalex.org/W2128215408","https://openalex.org/W2129512464","https://openalex.org/W2129664952","https://openalex.org/W2130867126","https://openalex.org/W2131088173","https://openalex.org/W2134081782","https://openalex.org/W2134760535","https://openalex.org/W2134815136","https://openalex.org/W2135746637","https://openalex.org/W2136391397","https://openalex.org/W2138397971","https://openalex.org/W2140520987","https://openalex.org/W2140807512","https://openalex.org/W2142041118","https://openalex.org/W2145183598","https://openalex.org/W2145518097","https://openalex.org/W2146616032","https://openalex.org/W2150006377","https://openalex.org/W2150829690","https://openalex.org/W2151381531","https://openalex.org/W2152688294","https://openalex.org/W2154700985","https://openalex.org/W2155203442","https://openalex.org/W2155547047","https://openalex.org/W2158356057","https://openalex.org/W2160173410","https://openalex.org/W2160284047","https://openalex.org/W2161810908","https://openalex.org/W2161949681","https://openalex.org/W2163608951","https://openalex.org/W2164915678","https://openalex.org/W2167853271","https://openalex.org/W2169713067","https://openalex.org/W2171217796","https://openalex.org/W2405171099","https://openalex.org/W2413169435","https://openalex.org/W2471460321","https://openalex.org/W4246973877","https://openalex.org/W4249445847"],"related_works":["https://openalex.org/W105907814","https://openalex.org/W197858118","https://openalex.org/W1498056856","https://openalex.org/W2126105922","https://openalex.org/W4306909234","https://openalex.org/W1969635156","https://openalex.org/W2210670953","https://openalex.org/W3113109430","https://openalex.org/W2053025379","https://openalex.org/W88373577"],"abstract_inverted_index":{"The":[0,106,185],"role":[1,28],"of":[2,21,29,34,61,74,109,113,122,128,134,187],"nitric":[3,52],"oxide":[4,53],"(NO)":[5],"in":[6,31,39,56,70,102,155],"cancer":[7,78,89,194],"development":[8,33,117,150],"has":[9,64,99],"become":[10],"a":[11,141],"very":[12],"active":[13,120],"research":[14,123],"area.":[15],"This":[16,96],"review":[17],"presents":[18],"an":[19,26,119],"overview":[20],"many":[22,45,103],"studies":[23],"that":[24,69],"implicate":[25],"important":[27],"NO":[30,49,75,87,114,131],"the":[32,62,126,158,163,171,179],"cancer.":[35],"These":[36],"include":[37,151],"results":[38],"experimental":[40,104],"models":[41],"as":[42,44],"well":[43],"observations":[46],"made":[47],"on":[48],"and":[50,92,124,137,175,197],"inducible":[51],"synthase":[54],"(iNOS)":[55],"human":[57],"cancers.":[58],"Our":[59],"survey":[60],"literature":[63],"allowed":[65],"us":[66],"to":[67,84],"conclude":[68],"general":[71],"large":[72],"levels":[73,86,112],"will":[76],"kill":[77],"cells":[79],"but":[80],"paradoxically":[81],"at":[82],"intermediate":[83,111],"lower":[85],"prevents":[88,193],"cell":[90,195,200],"apoptosis":[91,196],"enhances":[93,190,198],"tumor":[94,116,149,159],"growth.":[95,201],"basic":[97],"tenet":[98],"been":[100],"demonstrated":[101],"models.":[105],"mechanistic":[107],"basis":[108],"how":[110],"mediate":[115],"is":[118,125],"area":[121],"subject":[127],"this":[129],"review.":[130],"mediated":[132],"S-nitrosylation":[133,186],"key":[135],"enzymes":[136],"regulatory":[138],"proteins":[139,145,189],"plays":[140],"critical":[142],"role.":[143],"Key":[144],"S-nitrosylated":[146],"which":[147,166,182],"enhance":[148],"several":[152],"caspases":[153],"involved":[154],"apoptosis,":[156,169],"PTEN":[157],"suppressor":[160],"protein,":[161],"Bcl-2":[162],"mitochondrial":[164],"protein":[165,174,181],"protects":[167],"from":[168],"OGG1":[170],"DNA":[172,191],"repair":[173],"methionine":[176],"adenosyl":[177],"transferase":[178],"liver":[180],"synthesizes":[183],"adenosylmethionine.":[184],"these":[188],"mutations,":[192],"oncogenic":[199]},"counts_by_year":[{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}