{"id":"https://openalex.org/W2035361237","doi":"https://doi.org/10.1186/1868-7083-5-s1-s11","title":"Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice","display_name":"Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2035361237","doi":"https://doi.org/10.1186/1868-7083-5-s1-s11","mag":"2035361237"},"language":"en","primary_location":{"id":"doi:10.1186/1868-7083-5-s1-s11","doi":"https://doi.org/10.1186/1868-7083-5-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1868-7083-5-s1-s11","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/1868-7083-5-S1-S11","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/1868-7083-5-S1-S11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070610028","display_name":"Oliver M. Dovey","orcid":"https://orcid.org/0000-0003-3586-4813","observed_orcids":["https://orcid.org/0000-0003-3586-4813"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Oliver M Dovey","raw_affiliation_strings":["Department of Biochemistry, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK","The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","University of Leicester","Wellcome Trust Genome Campus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"University of Leicester","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Wellcome Trust Genome Campus","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033352497","display_name":"George S. Vasilliou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George Vasilliou","raw_affiliation_strings":["The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","Wellcome Trust Genome Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"Wellcome Trust Genome Campus;","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079556556","display_name":"Allan Bradley","orcid":"https://orcid.org/0000-0002-2349-8839","observed_orcids":["https://orcid.org/0000-0002-2349-8839"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Allan Bradley","raw_affiliation_strings":["The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","Wellcome Trust Genome Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"Wellcome Trust Genome Campus;","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029190361","display_name":"Shaun M. Cowley","orcid":"https://orcid.org/0000-0002-2510-1305","observed_orcids":["https://orcid.org/0000-0002-2510-1305"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shaun M Cowley","raw_affiliation_strings":["Department of Biochemistry, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK","University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070610028"],"corresponding_institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802476451","https://openalex.org/I87048295"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.447,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63963251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":1.0},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.902999997138977},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7870000004768372},{"id":"https://openalex.org/keywords/corepressor-complex","display_name":"corepressor complex","score":0.7269999980926514},{"id":"https://openalex.org/keywords/sin3a","display_name":"SIN3A","score":0.7799999713897705},{"id":"https://openalex.org/keywords/corest","display_name":"CoREST","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8040000200271606},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8650000095367432},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.7570000290870667},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7978712320327759},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.6513398885726929},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.5219811201095581},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.5059365630149841},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46187567710876465},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.44188374280929565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42419975996017456},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.42238667607307434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3563493490219116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3422788679599762},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3409808874130249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32340872287750244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12922599911689758}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1868-7083-5-s1-s11","doi":"https://doi.org/10.1186/1868-7083-5-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1868-7083-5-s1-s11","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/1868-7083-5-S1-S11","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2745536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3751628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3751628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3751628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Epigenetics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1868-7083-5-s1-s11","doi":"https://doi.org/10.1186/1868-7083-5-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1868-7083-5-s1-s11","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/1868-7083-5-S1-S11","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035361237.pdf","grobid_xml":"https://content.openalex.org/works/W2035361237.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2156876163","https://openalex.org/W7064255641","https://openalex.org/W1987147220","https://openalex.org/W2588623689","https://openalex.org/W1493306111","https://openalex.org/W2071962829","https://openalex.org/W2036700704","https://openalex.org/W313927091","https://openalex.org/W4285733755","https://openalex.org/W1994746194"],"abstract_inverted_index":{"The":[0],"highly":[1],"related":[2],"enzymes,":[3],"histone":[4],"deacetylase":[5],"1":[6],"and":[7,21,35,93,126],"2":[8],"(HDAC1/2),":[9],"regulate":[10],"chromatin":[11],"structure":[12],"as":[13,39],"the":[14,18,31,81,115,131,158,186],"catalytic":[15],"core":[16],"of":[17,51,56,104,110,124,130,150,171,188],"Sin3A,":[19],"NuRD":[20],"CoREST":[22],"co-repressor":[23],"complexes.":[24],"To":[25],"better":[26],"understand":[27],"their":[28,37],"role":[29],"in":[30,69,73,114,153,167],"adaptive":[32],"immune":[33],"system":[34],"inform":[36],"exploitation":[38],"drug":[40],"targets,":[41],"we":[42],"have":[43],"generated":[44],"mice":[45],"with":[46,87,157,191],"a":[47,70,94,99,164],"T-cell":[48],"specific":[49],"inactivation":[50,67],"both":[52],"Hdac1/2":[53],"genes.":[54],"Loss":[55],"either":[57],"HDAC1":[58],"or":[59],"HDAC2":[60],"alone":[61],"has":[62,139],"little":[63],"effect,":[64],"while":[65],"dual":[66],"results":[68],"5-fold":[71],"reduction":[72,166],"thymocyte":[74],"cellularity,":[75],"accompanied":[76],"by":[77,102,107],"developmental":[78],"arrest":[79],"at":[80],"double-negative":[82],"to":[83,155],"double-positive":[84],"transition.":[85],"Mice":[86],"reduced":[88],"HDAC1/2":[89,168],"activity":[90,169],"(Hdac1":[91],"deleted":[92],"single":[95],"Hdac2":[96],"allele)":[97],"develop":[98],"lethal":[100],"pathology":[101],"3-months":[103],"age,":[105],"caused":[106],"neoplastic":[108],"transformation":[109],"immature":[111],"T":[112],"cells":[113,118,146,190],"thymus.":[116],"Tumor":[117],"become":[119],"aneuploid,":[120],"express":[121],"increased":[122,148],"levels":[123,129,149],"c-Myc":[125],"show":[127,147],"elevated":[128],"DNA":[132],"damage":[133],"marker,":[134],"\u03b3H2AX.":[135],"Intriguingly,":[136],"recent":[137],"data":[138],"shown":[140],"that":[141],"these":[142],"same":[143],"hypomorphic":[144],"tumour":[145,176],"cell":[151],"death":[152],"response":[154],"treatment":[156,187],"HDAC":[159,193],"inhibitor,":[160],"SAHA.":[161],"Therefore,":[162],"although":[163],"partial":[165],"(>60%":[170],"WT)":[172],"could":[173],"potentially":[174],"encourage":[175],"growth,":[177],"it":[178],"may":[179],"also":[180],"be":[181],"an":[182],"Achilles":[183],"heel":[184],"for":[185],"cancer":[189],"standard":[192],"inhibitor":[194],"therapy.":[195]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
