{"id":"https://openalex.org/W2035358971","doi":"https://doi.org/10.1016/0168-9525(87)90268-x","title":"Fragile sites in human chromosomes as regions of late-replicating DNA","display_name":"Fragile sites in human chromosomes as regions of late-replicating DNA","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2035358971","doi":"https://doi.org/10.1016/0168-9525(87)90268-x","mag":"2035358971"},"language":"en","primary_location":{"id":"doi:10.1016/0168-9525(87)90268-x","doi":"https://doi.org/10.1016/0168-9525(87)90268-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-9525(87)90268-x","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108483670","display_name":"Charles D. Laird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Laird","raw_affiliation_strings":["C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007669600","display_name":"Elizabeth Jaffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Jaffe","raw_affiliation_strings":["E. Jaffe and G. Karpen are at the Dept of Genetics, University of Washington, NJ-15, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E. Jaffe and G. Karpen are at the Dept of Genetics, University of Washington, NJ-15, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003859020","display_name":"Gary H. Karpen","orcid":"https://orcid.org/0000-0003-1534-0385","observed_orcids":["https://orcid.org/0000-0003-1534-0385"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Karpen","raw_affiliation_strings":["E. Jaffe and G. Karpen are at the Dept of Genetics, University of Washington, NJ-15, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E. Jaffe and G. Karpen are at the Dept of Genetics, University of Washington, NJ-15, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111995637","display_name":"Mary M. Lamb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Lamb","raw_affiliation_strings":["C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015635289","display_name":"Rebecca Nelson","orcid":"https://orcid.org/0000-0002-9026-7803","observed_orcids":["https://orcid.org/0000-0002-9026-7803"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Nelson","raw_affiliation_strings":["C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Laird, M. Lamb and R. Nelson are at the Dept of Zoology, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":2.4617,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.89781022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":null,"first_page":"274","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.1826999932527542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fragile-sites","display_name":"fragile sites","score":0.9819999933242798},{"id":"https://openalex.org/keywords/human-chromosomes","display_name":"human chromosomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/fragile-x-syndrome","display_name":"fragile X syndrome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C60449816","wikidata":"https://www.wikidata.org/wiki/Q5113903","display_name":"Chromosomal fragile site","level":4,"score":0.9255640506744385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9203387498855591},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6094830632209778},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6016621589660645},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4970586597919464},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4711310565471649},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3263125419616699},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1734611988067627}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0168-9525(87)90268-x","doi":"https://doi.org/10.1016/0168-9525(87)90268-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-9525(87)90268-x","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W68196593","https://openalex.org/W202113929","https://openalex.org/W230152137","https://openalex.org/W1217246038","https://openalex.org/W1498462216","https://openalex.org/W1519629411","https://openalex.org/W1606947195","https://openalex.org/W1636503892","https://openalex.org/W1875189464","https://openalex.org/W1967048018","https://openalex.org/W1967260949","https://openalex.org/W1968071813","https://openalex.org/W1969883059","https://openalex.org/W1974993967","https://openalex.org/W1978416076","https://openalex.org/W1981136338","https://openalex.org/W1982124514","https://openalex.org/W1983080694","https://openalex.org/W1987063512","https://openalex.org/W2000974408","https://openalex.org/W2004498792","https://openalex.org/W2005721080","https://openalex.org/W2011678356","https://openalex.org/W2029146706","https://openalex.org/W2031844390","https://openalex.org/W2034536281","https://openalex.org/W2036074921","https://openalex.org/W2038108954","https://openalex.org/W2044428132","https://openalex.org/W2044838776","https://openalex.org/W2046530033","https://openalex.org/W2047390971","https://openalex.org/W2047636749","https://openalex.org/W2051406511","https://openalex.org/W2051947938","https://openalex.org/W2052028037","https://openalex.org/W2053766378","https://openalex.org/W2060097002","https://openalex.org/W2080501447","https://openalex.org/W2081084277","https://openalex.org/W2085837106","https://openalex.org/W2088736383","https://openalex.org/W2092299362","https://openalex.org/W2092441446","https://openalex.org/W2093896423","https://openalex.org/W2093999606","https://openalex.org/W2102858539","https://openalex.org/W2113051345","https://openalex.org/W2120890729","https://openalex.org/W2162778136","https://openalex.org/W2180937206","https://openalex.org/W2192853686","https://openalex.org/W2235495502","https://openalex.org/W2269048888","https://openalex.org/W2305925046","https://openalex.org/W2320083580","https://openalex.org/W2332810361","https://openalex.org/W4211087645","https://openalex.org/W4243520112"],"related_works":["https://openalex.org/W7067366116","https://openalex.org/W2126555879","https://openalex.org/W2123586144","https://openalex.org/W7005861971","https://openalex.org/W119566334","https://openalex.org/W289587567","https://openalex.org/W2056946366","https://openalex.org/W2047579772","https://openalex.org/W4246379650","https://openalex.org/W2108556453"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
