{"id":"https://openalex.org/W2035309552","doi":"https://doi.org/10.1016/s0194-5998(98)70071-3","title":"Age\u2010 and gender\u2010related elastin distribution changes in human vocal folds: Student Research Award 1997","display_name":"Age\u2010 and gender\u2010related elastin distribution changes in human vocal folds: Student Research Award 1997","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2035309552","doi":"https://doi.org/10.1016/s0194-5998(98)70071-3","mag":"2035309552","pmid":"https://pubmed.ncbi.nlm.nih.gov/9781983"},"language":"en","primary_location":{"id":"doi:10.1016/s0194-5998(98)70071-3","doi":"https://doi.org/10.1016/s0194-5998(98)70071-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0194-5998(98)70071-3","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103058626","display_name":"Thomas Hale Hammond","orcid":"https://orcid.org/0000-0002-4151-7845","observed_orcids":["https://orcid.org/0000-0002-4151-7845"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801996072","display_name":"LDS Hospital","ror":"https://ror.org/0360cq027","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2801996072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H. Hammond","raw_affiliation_strings":["L.D.S. Hospital Salt Lake City Utah","University of Utah Salt Lake City Utah","University of Utah, Salt Lake City 84113, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L.D.S. Hospital Salt Lake City Utah","institution_ids":["https://openalex.org/I2801996072"]},{"raw_affiliation_string":"University of Utah Salt Lake City Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah, Salt Lake City 84113, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544042","display_name":"Steven D. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Gray","raw_affiliation_strings":["University of Utah Salt Lake City Utah","Salt Lake City, Utah, and Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Salt Lake City Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Salt Lake City, Utah, and Bethesda, Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109011582","display_name":"John E. Butler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Butler","raw_affiliation_strings":["University of Utah Salt Lake City Utah","Salt Lake City, Utah, and Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Salt Lake City Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Salt Lake City, Utah, and Bethesda, Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655981","display_name":"Ruixia Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruixia Zhou","raw_affiliation_strings":["National Laboratory of Medicine Bethesda Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Medicine Bethesda Maryland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113547622","display_name":"Elizabeth Hammond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Hammond","raw_affiliation_strings":["Salt Lake City, Utah, and Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salt Lake City, Utah, and Bethesda, Maryland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":5.5426,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.95652174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"119","issue":"4","first_page":"314","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11260","display_name":"Tracheal and airway disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10403","display_name":"Phonetics and Phonology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vocal-fold","display_name":"vocal cords","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lamina-propria","display_name":"lamina propria","score":0.996999979019165},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.890999972820282},{"id":"https://openalex.org/keywords/laryngeal-biomechanics","display_name":"laryngeal biomechanics","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.9629278182983398},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.9313517212867737},{"id":"https://openalex.org/C2780336059","wikidata":"https://www.wikidata.org/wiki/Q215558","display_name":"Vocal folds","level":3,"score":0.5373998880386353},{"id":"https://openalex.org/C2777989353","wikidata":"https://www.wikidata.org/wiki/Q5985227","display_name":"Lamina","level":2,"score":0.5373861193656921},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5220413208007812},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.42742544412612915},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3997196555137634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39819252490997314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39379042387008667},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.3399440348148346},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3100011944770813},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.18557432293891907}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007454","descriptor_name":"Iodides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007821","descriptor_name":"Laryngeal Muscles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007821","descriptor_name":"Laryngeal Muscles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0194-5998(98)70071-3","doi":"https://doi.org/10.1016/s0194-5998(98)70071-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0194-5998(98)70071-3","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:9781983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9781983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5734492535","display_name":"NATIONAL CENTER FOR VOICE AND SPEECH","funder_award_id":"P60DC000976","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W297918892","https://openalex.org/W581636683","https://openalex.org/W1497272095","https://openalex.org/W1984564748","https://openalex.org/W1985542043","https://openalex.org/W1993491380","https://openalex.org/W2028726438","https://openalex.org/W2043117150","https://openalex.org/W2065177895","https://openalex.org/W2085944634","https://openalex.org/W2147681357","https://openalex.org/W2273898196","https://openalex.org/W2317198665","https://openalex.org/W2332674344","https://openalex.org/W2424876848","https://openalex.org/W4205916881"],"related_works":["https://openalex.org/W2038736029","https://openalex.org/W129994538","https://openalex.org/W2147681357","https://openalex.org/W2007566658","https://openalex.org/W2613559418","https://openalex.org/W2000083364","https://openalex.org/W2191035430","https://openalex.org/W2065177895","https://openalex.org/W2084366251","https://openalex.org/W2321338432"],"abstract_inverted_index":{"The":[0,53,124,179],"composition":[1],"of":[2,26,43,85,95,121,151,163,170,196],"the":[3,23,27,35,48,61,70,104,119,136,152,164,187,197,201,220],"lamina":[4,28,105,188],"propria":[5,106,189],"in":[6,22,60,132,155,167,200,208,212,227,244],"human":[7],"vocal":[8,15,71,110],"folds":[9,72,147],"has":[10],"been":[11],"shown":[12],"to":[13,47,101,109,224],"affect":[14],"performance.":[16],"Elastin":[17],"plays":[18],"a":[19,191],"significant":[20,175],"role":[21],"biomechanical":[24],"effects":[25],"propria.":[29],"We":[30,68,217],"obtained":[31],"19":[32],"larynges":[33],"from":[34,39,99,135],"state":[36],"medical":[37],"examiner":[38],"subjects":[40,59,159,210,229],"whose":[41],"cause":[42],"death":[44],"was":[45,129,206],"unrelated":[46],"trachea":[49],"and":[50,57,64,80,157,214],"laryngeal":[51],"regions.":[52],"sample":[54],"contained":[55],"male":[56],"female":[58],"infant,":[62],"adult,":[63],"geriatric":[65,139,158,209,228],"age":[66],"groups.":[67],"stained":[69],"for":[73,91],"elastin":[74,96,113,133,153,165,198],"with":[75,83,118,183,194,236],"Verhoeff's":[76],"elastic":[77],"tissue":[78],"stain":[79],"studied":[81],"them":[82],"use":[84,120],"an":[86,130],"image":[87],"analysis":[88],"system":[89],"configured":[90],"light":[92],"microscopy.":[93],"Distributions":[94],"were":[97,115,144,173,181],"measured":[98],"superficial":[100],"deep":[102],"within":[103],"(from":[107],"epithelium":[108],"muscle).":[111],"These":[112],"distributions":[114,180],"then":[116],"compared":[117],"statistical":[122],"software.":[123],"data":[125],"showed":[126],"that":[127,186,219],"there":[128],"increase":[131],"content":[134],"infant":[137],"through":[138],"stages.":[140],"No":[141],"gender-related":[142],"differences":[143],"found.":[145],"Infant":[146],"had":[148,160],"about":[149,161],"23%":[150],"found":[154,166],"adults,":[156],"879%":[162],"adults.":[168],"Both":[169],"these":[171],"results":[172],"statistically":[174],"(p":[176],"<":[177],"0.05).":[178],"consistent":[182],"previous":[184],"observations":[185],"is":[190,232],"layered":[192],"structure":[193],"most":[195],"present":[199],"intermediate":[202],"layer.":[203],"This":[204],"layer":[205],"larger":[207,226],"than":[211],"adult":[213],"pediatric":[215,245],"subjects.":[216,246],"observed":[218],"fiber":[221],"diameter":[222],"appeared":[223,243],"be":[225],"(this":[230],"observation":[231],"currently":[233],"being":[234],"verified":[235],"electron":[237],"microscopy)":[238],"whereas":[239],"smaller,":[240],"spiraled":[241],"fibers":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}