{"id":"https://openalex.org/W2035303840","doi":"https://doi.org/10.1016/j.jalz.2014.04.284","title":"O3\u201003\u201005: LONGITUDINAL MRI AND NEUROPSYCHOLOGICAL CHANGES IN SYMPTOMATIC FRONTOTEMPORAL LOBAR DEGENERATION SUBJECTS WITH MUTATIONS IN MAPT, PGRN, AND C9ORF72","display_name":"O3\u201003\u201005: LONGITUDINAL MRI AND NEUROPSYCHOLOGICAL CHANGES IN SYMPTOMATIC FRONTOTEMPORAL LOBAR DEGENERATION SUBJECTS WITH MUTATIONS IN MAPT, PGRN, AND C9ORF72","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2035303840","doi":"https://doi.org/10.1016/j.jalz.2014.04.284","mag":"2035303840"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2014.04.284","doi":"https://doi.org/10.1016/j.jalz.2014.04.284","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.284","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2014.04.284","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2014.04.284","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005572080","display_name":"Jonathan Graff\u2010Radford","orcid":"https://orcid.org/0000-0003-2770-0691","observed_orcids":["https://orcid.org/0000-0003-2770-0691"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Graff\u2010Radford","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063489595","display_name":"David Thomas Jones","orcid":"https://orcid.org/0000-0002-4807-9833","observed_orcids":["https://orcid.org/0000-0002-4807-9833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Jones","raw_affiliation_strings":["Mayo Clinic Rochester Rochester Minnesota United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester Rochester Minnesota United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022452703","display_name":"Stephen D. Weigand","orcid":"https://orcid.org/0000-0002-4541-9011","observed_orcids":["https://orcid.org/0000-0002-4541-9011"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Weigand","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026250910","display_name":"Scott A. Przybelski","orcid":"https://orcid.org/0009-0009-3437-3773","observed_orcids":["https://orcid.org/0009-0009-3437-3773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Przybelski","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089684856","display_name":"Jennifer Louise Whitwell","orcid":"https://orcid.org/0000-0001-6914-1563","observed_orcids":["https://orcid.org/0000-0001-6914-1563"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Louise Whitwell","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050718938","display_name":"Matthew L. Senjem","orcid":"https://orcid.org/0000-0001-9308-9275","observed_orcids":["https://orcid.org/0000-0001-9308-9275"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew Senjem","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Knopman","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091046259","display_name":"Neill R. Graff\u2010Radford","orcid":"https://orcid.org/0000-0001-9847-9096","observed_orcids":["https://orcid.org/0000-0001-9847-9096"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neill R. Graff\u2010Radford","raw_affiliation_strings":["Mayo Clinic , Jacksonville, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Jacksonville, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007824103","display_name":"Keith A. Josephs","orcid":"https://orcid.org/0000-0003-2930-8634","observed_orcids":["https://orcid.org/0000-0003-2930-8634"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Josephs","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022481370","display_name":"Zbigniew K. Wszo\u0142ek","orcid":"https://orcid.org/0000-0001-5487-1053","observed_orcids":["https://orcid.org/0000-0001-5487-1053"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Wszolek","raw_affiliation_strings":["Mayo Clinic , Jacksonville, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Jacksonville, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043921358","display_name":"Prashanthi Vemuri","orcid":"https://orcid.org/0000-0003-4286-0589","observed_orcids":["https://orcid.org/0000-0003-4286-0589"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanthi Vemuri","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462803","display_name":"Julie A. Fields","orcid":"https://orcid.org/0000-0002-1282-9866","observed_orcids":["https://orcid.org/0000-0002-1282-9866"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Fields","raw_affiliation_strings":["Mayo Clinic College of Medicine, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic College of Medicine, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036878959","display_name":"Tanis J. Ferman","orcid":"https://orcid.org/0000-0001-8377-6194","observed_orcids":["https://orcid.org/0000-0001-8377-6194"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanis J. Ferman","raw_affiliation_strings":["Mayo Clinic Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047885227","display_name":"John Alexander Lucas","orcid":"https://orcid.org/0000-0001-6756-1492","observed_orcids":["https://orcid.org/0000-0001-6756-1492"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lucas","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001313680","display_name":"Val J. Lowe","orcid":"https://orcid.org/0000-0002-5612-1667","observed_orcids":["https://orcid.org/0000-0002-5612-1667"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J. Lowe","raw_affiliation_strings":["Mayo Clinic Rochester Rochester Minnesota United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester Rochester Minnesota United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087352076","display_name":"Ralitza H. Gavrilova","orcid":"https://orcid.org/0000-0002-4942-6358","observed_orcids":["https://orcid.org/0000-0002-4942-6358"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralitza Gavrilova","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karen Kuntz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Kuntz","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110065538","display_name":"Mariely DeJesus Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariely DeJesus Hernandez","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064561010","display_name":"Matthew Baker","orcid":"https://orcid.org/0000-0002-0002-1907","observed_orcids":["https://orcid.org/0000-0002-0002-1907","https://orcid.org/0009-0001-2691-5757"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Baker","raw_affiliation_strings":["Mayo Clinic Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048408999","display_name":"Rosa Rademakers","orcid":"https://orcid.org/0000-0002-4049-0863","observed_orcids":["https://orcid.org/0000-0002-4049-0863"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Rademakers","raw_affiliation_strings":["Mayo Clinic Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Carl Petersen","raw_affiliation_strings":["Mayo Clinic Rochester Rochester Minnesota United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester Rochester Minnesota United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077933873","display_name":"Kejal Kantarci","orcid":"https://orcid.org/0000-0002-8001-2081","observed_orcids":["https://orcid.org/0000-0002-8001-2081"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kejal Kantarci","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Jack","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066352714","display_name":"Bradley F. Boeve","orcid":"https://orcid.org/0000-0002-4153-8187","observed_orcids":["https://orcid.org/0000-0002-4153-8187"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley F. Boeve","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.2039,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56359547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"4S_Part_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-frontotemporal-lobar-degeneration","display_name":"familial frontotemporal lobar degeneration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mapt-mutations","display_name":"MAPT mutations","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.8790780305862427},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.8245106935501099},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.4907022714614868},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4652795195579529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46164077520370483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4608537554740906},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4306516647338867},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3592034578323364},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26644524931907654},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2511645257472992},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.23353305459022522},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2014.04.284","doi":"https://doi.org/10.1016/j.jalz.2014.04.284","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.284","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2014.04.284","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2014.04.284","doi":"https://doi.org/10.1016/j.jalz.2014.04.284","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.284","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2014.04.284","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035303840.pdf","grobid_xml":"https://content.openalex.org/works/W2035303840.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102960012","https://openalex.org/W4205868473","https://openalex.org/W2220252304","https://openalex.org/W4410764613","https://openalex.org/W3112317484","https://openalex.org/W2538981190","https://openalex.org/W2593764924","https://openalex.org/W4389464262","https://openalex.org/W2533175030","https://openalex.org/W2010503517"],"abstract_inverted_index":{"Familial":[0],"frontotemporal":[1,56,358],"lobar":[2],"degeneration":[3],"(f-FTLD)":[4],"is":[5,320,337],"commonly":[6],"caused":[7],"by":[8,365],"mutations":[9,292],"in":[10,55,63,120,197,216,239,260,272,293,304,357],"MAPT,":[11,65,294],"progranulin":[12],"(PGRN)":[13],"and":[14,22,47,59,67,95,115,134,140,177,223,270,296,301,307,327,341],"C9ORF72.":[15],"Our":[16],"objectives":[17],"were":[18,45,258],"to":[19,30,51,84,136,200,207,220,267,280],"compare":[20,52],"imaging":[21,141],"neuropsychological":[23,233,354],"progression":[24],"among":[25,124,251,287],"these":[26],"three":[27,253],"mutation":[28,69,122,189,229,329,343,347],"groups":[29],"prepare":[31],"for":[32,79,155,322,325,362],"clinical":[33,139],"trials.":[34],"Available":[35],"neuroimaging":[36],"data":[37,97,142,152],"on":[38,98,232,245,263,275,352],"f-FTLD":[39,121,289],"patients":[40],"evaluated":[41],"at":[42],"Mayo":[43],"Clinic":[44],"reviewed":[46],"analyzed.":[48],"In":[49],"order":[50],"longitudinal":[53,96,138],"changes":[54,257],"volume":[57,61,318,335],"(FTV)":[58],"ventricular":[60],"(VV)":[62],"symptomatic":[64,288],"PGRN":[66,168,188,217,261,295,323],"C9ORF72":[68,179,208,224,281,328,342],"carriers,":[70,269,330,344],"the":[71,99,148,246,252,264,276,315,332],"Symmetric":[72],"Diffeomorphic":[73],"Image":[74],"Normalization":[75],"method":[76],"was":[77,153,214,236],"used":[78,127],"normalization":[80],"of":[81,195,243,256,317,334],"serial":[82],"scans":[83],"obtain":[85],"Tensor":[86],"Based":[87],"Morphometry":[88],"(TBM-SyN)":[89],"maps.":[90],"We":[91,126],"also":[92],"compared":[93,199,206,219,266,279],"baseline":[94,146,240],"Controlled":[100],"Oral":[101],"Word":[102],"Association":[103],"Test":[104,107,113],"(COWAT),":[105],"Trailmaking":[106],"B":[108,278],"(TMT":[109],"B),":[110],"Boston":[111],"Naming":[112],"(BNT)":[114],"Category":[116],"Fluency":[117],"(Cat":[118],"Fl)":[119],"carriers":[123,190,230,262,274,348],"subjects.":[125,282],"linear":[128,309],"mixed":[129],"models":[130],"with":[131,143,203,291],"random":[132],"slopes":[133],"intercepts":[135],"analyze":[137],"years":[144],"from":[145],"as":[147],"time":[149,361],"scale.":[150],"MR":[151],"available":[154],"21":[156],"MAPT":[157,201,221,268,273,326,340],"kindred":[158],"subjects":[159,169,180,218,225,290,364],"(age":[160,170,181],"50":[161],"\u00b1":[162,172,183],"12":[163],"years,":[164,174,185],"57%":[165],"male),":[166],"11":[167,178],"64":[171],"9":[173],"45%":[175],"male)":[176],"62":[182],"10":[184],"55%":[186],"male).":[187],"had":[191],"a":[192,204,305],"greater":[193,215,259,271,321],"rate":[194,242,316,333],"change":[196,213,244,319,336],"FTV":[198,299],"(p=0.01);":[202],"trend":[205],"(p=0.07).":[209],"(Figure":[210],"1)":[211,298],"VV":[212,302],"(p<0.001);":[222],"(p=0.003).":[226],"While":[227],"all":[228,346],"declined":[231],"measures,":[234],"there":[235],"no":[237],"difference":[238],"or":[241,248],"COWAT":[247],"Cat":[249],"Fl":[250],"groups.":[254],"Rates":[255],"BNT":[265],"TMT":[277],"These":[283],"findings":[284],"suggest":[285],"that":[286],"C9ORF72:":[297],"decreases":[300],"increases":[303],"measurable":[306],"relatively":[308],"fashion":[310],"using":[311],"TBM-SyN":[312],"maps,":[313],"2)":[314],"than":[324],"3)":[331],"similar":[338],"between":[339],"4)":[345],"have":[349],"declining":[350],"performance":[351],"key":[353],"measures.":[355],"Volume":[356],"region":[359],"over":[360],"individual":[363],"group.":[366]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}