{"id":"https://openalex.org/W2035236156","doi":"https://doi.org/10.1164/ajrccm.155.4.9105068","title":"Quality of Life Changes in COPD Patients Treated With Salmeterol","display_name":"Quality of Life Changes in COPD Patients Treated With Salmeterol","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2035236156","doi":"https://doi.org/10.1164/ajrccm.155.4.9105068","mag":"2035236156","pmid":"https://pubmed.ncbi.nlm.nih.gov/9105068"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.155.4.9105068","doi":"https://doi.org/10.1164/ajrccm.155.4.9105068","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.155.4.9105068","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107387136","display_name":"Peter M. Jones","orcid":"https://orcid.org/0000-0003-1201-2335","observed_orcids":["https://orcid.org/0000-0003-1201-2335"]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P W Jones","raw_affiliation_strings":["Division of Physiological Medicine, St. George's Hospital Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiological Medicine, St. George's Hospital Medical School, London, United Kingdom","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034315954","display_name":"T K Bosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T K Bosh","raw_affiliation_strings":["Division of Physiological Medicine, St. George's Hospital Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiological Medicine, St. George's Hospital Medical School, London, United Kingdom","institution_ids":["https://openalex.org/I165862685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165862685"],"apc_list":null,"apc_paid":null,"fwci":16.6163,"has_fulltext":false,"cited_by_count":491,"citation_normalized_percentile":{"value":0.9937431,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"155","issue":"4","first_page":"1283","last_page":"1289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/salmeterol","display_name":"salmeterol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9010000228881836},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.8399999737739563},{"id":"https://openalex.org/keywords/st-george-s-respiratory-questionnaire","display_name":"St George's Respiratory Questionnaire","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/metered-dose-inhaler","display_name":"MDI","score":0.8299999833106995},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2776719499","wikidata":"https://www.wikidata.org/wiki/Q424333","display_name":"Salmeterol","level":3,"score":0.9847307205200195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9596557021141052},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8165280818939209},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7821232676506042},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6663992404937744},{"id":"https://openalex.org/C111278954","wikidata":"https://www.wikidata.org/wiki/Q17069312","display_name":"Minimal clinically important difference","level":3,"score":0.518858790397644},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.47770193219184875},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4651300609111786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4474411904811859},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.4227503836154938},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3963072597980499},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37150484323501587},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3557191789150238},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.17874285578727722},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068299","descriptor_name":"Salmeterol Xinafoate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.155.4.9105068","doi":"https://doi.org/10.1164/ajrccm.155.4.9105068","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.155.4.9105068","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},{"id":"pmid:9105068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9105068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W139152004","https://openalex.org/W787653148","https://openalex.org/W1572030781","https://openalex.org/W1583848026","https://openalex.org/W1831800100","https://openalex.org/W1933080793","https://openalex.org/W1939187171","https://openalex.org/W1955862611","https://openalex.org/W1972056918","https://openalex.org/W1983378915","https://openalex.org/W2002550127","https://openalex.org/W2005383122","https://openalex.org/W2006131537","https://openalex.org/W2008904736","https://openalex.org/W2009485602","https://openalex.org/W2028618548","https://openalex.org/W2052977441","https://openalex.org/W2059613978","https://openalex.org/W2083184394","https://openalex.org/W2083436606","https://openalex.org/W2084197879","https://openalex.org/W2097667004","https://openalex.org/W2139679062","https://openalex.org/W2148534399","https://openalex.org/W2336268573","https://openalex.org/W2419720582"],"related_works":["https://openalex.org/W2397999435","https://openalex.org/W2232672854","https://openalex.org/W2160431793","https://openalex.org/W2398092031","https://openalex.org/W2058584130","https://openalex.org/W2726836368","https://openalex.org/W2121211537","https://openalex.org/W2359241488","https://openalex.org/W4236205161","https://openalex.org/W2122235946"],"abstract_inverted_index":{"Changes":[0,151],"in":[1,9,68,74,88,98,104,125,152,176,186,190],"health-related":[2],"quality":[3],"of":[4,60,100],"life":[5],"(HRQoL)":[6],"were":[7,78,93],"evaluated":[8],"patients":[10,65,67],"with":[11,19,112,122,144,166,182],"chronic":[12],"obstructive":[13],"pulmonary":[14],"disease":[15],"(COPD)":[16],"following":[17],"treatment":[18,91],"placebo,":[20,113],"salmeterol":[21,76,114,145],"50":[22,115],"microg":[23,29,116,147],"twice":[24,30,117,148],"a":[25,31,85,118,136,149,161,173],"day":[26,32,119],"or":[27],"100":[28,146],"by":[33],"metered-dose":[34],"inhaler.":[35],"Patients":[36],"completed":[37],"the":[38,46,69,133],"disease-specific":[39],"St.":[40],"George's":[41],"Respiratory":[42],"Questionnaire":[43],"(SGRQ)":[44],"and":[45,56,72,108,128,154,188],"Medical":[47],"Outcomes":[48],"Study":[49],"Short":[50],"Form":[51],"36":[52],"(SF-36)":[53],"at":[54,96],"baseline":[55,97],"after":[57],"16":[58],"wk":[59],"treatment.":[61],"Data":[62],"from":[63,84],"283":[64],"(95":[66],"placebo":[70],"group":[71],"94":[73],"each":[75],"group)":[77],"available":[79],"for":[80,135],"HRQoL":[81,109],"analysis.":[82],"Apart":[83],"small":[86],"difference":[87],"ages,":[89],"all":[90],"groups":[92],"well":[94],"matched":[95],"terms":[99],"forced":[101],"expiratory":[102],"volume":[103],"one":[105],"second":[106],"(FEV1)":[107],"scores.":[110],"Compared":[111],"was":[120,141],"associated":[121,181],"significant":[123,138,164,184],"improvements":[124],"SGRQ":[126,153],"\"Total\"":[127],"\"Impacts\"":[129],"scores":[130,156],"which":[131],"exceeded":[132],"threshold":[134],"clinically":[137,183],"change.":[139],"This":[140,168],"not":[142],"seen":[143],"day.":[150],"SF-36":[155],"correlated.":[157],"They":[158],"also":[159],"showed":[160],"weak":[162],"but":[163],"relationship":[165],"FEV1.":[167],"study":[169],"has":[170],"shown":[171],"that":[172],"modest":[174],"change":[175],"lung":[177],"function":[178],"may":[179],"be":[180],"gain":[185],"health":[187],"well-being":[189],"COPD":[191],"patients.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
