{"id":"https://openalex.org/W2035230405","doi":"https://doi.org/10.1021/bi701682r","title":"Probing the Mechanism of Insulin Aggregation with Added Metalloporphyrins","display_name":"Probing the Mechanism of Insulin Aggregation with Added Metalloporphyrins","publication_year":2008,"publication_date":"2008-01-26","ids":{"openalex":"https://openalex.org/W2035230405","doi":"https://doi.org/10.1021/bi701682r","mag":"2035230405","pmid":"https://pubmed.ncbi.nlm.nih.gov/18220359"},"language":"en","primary_location":{"id":"doi:10.1021/bi701682r","doi":"https://doi.org/10.1021/bi701682r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701682r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014097990","display_name":"Scott P. Sibley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]},{"id":"https://openalex.org/I42321615","display_name":"Goucher College","ror":"https://ror.org/055ag3e81","country_code":"US","type":"education","lineage":["https://openalex.org/I42321615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott P. Sibley","raw_affiliation_strings":["Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081","institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057717995","display_name":"Katrina Sosinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]},{"id":"https://openalex.org/I42321615","display_name":"Goucher College","ror":"https://ror.org/055ag3e81","country_code":"US","type":"education","lineage":["https://openalex.org/I42321615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Sosinsky","raw_affiliation_strings":["Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081","institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034770023","display_name":"Lisa E. Gulian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]},{"id":"https://openalex.org/I42321615","display_name":"Goucher College","ror":"https://ror.org/055ag3e81","country_code":"US","type":"education","lineage":["https://openalex.org/I42321615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa E. Gulian","raw_affiliation_strings":["Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081","institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036685709","display_name":"Esther J. Gibbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]},{"id":"https://openalex.org/I42321615","display_name":"Goucher College","ror":"https://ror.org/055ag3e81","country_code":"US","type":"education","lineage":["https://openalex.org/I42321615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther J. Gibbs","raw_affiliation_strings":["Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081","institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037954508","display_name":"Robert F. Pasternack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]},{"id":"https://openalex.org/I42321615","display_name":"Goucher College","ror":"https://ror.org/055ag3e81","country_code":"US","type":"education","lineage":["https://openalex.org/I42321615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert F. Pasternack","raw_affiliation_strings":["Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Goucher College, Baltimore, Maryland 21204, and Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081","institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014097990"],"corresponding_institution_ids":["https://openalex.org/I118020396","https://openalex.org/I42321615"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7487,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.63655614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"47","issue":"9","first_page":"2858","last_page":"2865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.11699999868869781,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-aggregation","display_name":"insulin aggregation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/metalloporphyrins","display_name":"metalloporphyrins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tetrakis-4-sulfonatophenyl-porphyrin","display_name":"TPPS4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/porphyrin-dimers","display_name":"porphyrin dimers","score":0.8360000252723694},{"id":"https://openalex.org/keywords/amyloid-inhibition","display_name":"amyloid inhibition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/aggregation-kinetics","display_name":"aggregation kinetics","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.950877845287323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7796323299407959},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6522120237350464},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5380076766014099},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.5080990791320801},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.503020703792572},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.47859808802604675},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4146497845649719},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.339455246925354},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3099628686904907},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.181003600358963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.159174382686615},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1442379355430603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008665","descriptor_name":"Metalloporphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi701682r","doi":"https://doi.org/10.1021/bi701682r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701682r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18220359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18220359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:works.swarthmore.edu:fac-chemistry-1144","doi":null,"is_oa":false,"landing_page_url":"https://works.swarthmore.edu/fac-chemistry/145","pdf_url":null,"source":{"id":"https://openalex.org/S4377196506","display_name":"Works - Scholarship, Research, & Creative Expression (Swarthmore College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118020396","host_organization_name":"Swarthmore College","host_organization_lineage":["https://openalex.org/I118020396"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry & Biochemistry Faculty Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1968369580","https://openalex.org/W1983888048","https://openalex.org/W1992067976","https://openalex.org/W1999853753","https://openalex.org/W2001363066","https://openalex.org/W2014571034","https://openalex.org/W2018618746","https://openalex.org/W2028621029","https://openalex.org/W2030570316","https://openalex.org/W2032200978","https://openalex.org/W2034173757","https://openalex.org/W2043282395","https://openalex.org/W2043761562","https://openalex.org/W2049425597","https://openalex.org/W2055676171","https://openalex.org/W2057383918","https://openalex.org/W2059403208","https://openalex.org/W2064212761","https://openalex.org/W2067335071","https://openalex.org/W2070380111","https://openalex.org/W2092625134","https://openalex.org/W2095322530","https://openalex.org/W2096425372","https://openalex.org/W2096601751","https://openalex.org/W2110052787","https://openalex.org/W2134272142","https://openalex.org/W2162575609","https://openalex.org/W2163210644","https://openalex.org/W2169627384","https://openalex.org/W2316950343"],"related_works":["https://openalex.org/W2018618746","https://openalex.org/W2972897922","https://openalex.org/W3201987105","https://openalex.org/W4213373342","https://openalex.org/W3108971267","https://openalex.org/W2375874334","https://openalex.org/W4390796551","https://openalex.org/W2601216328","https://openalex.org/W2751234617","https://openalex.org/W1987734353"],"abstract_inverted_index":{"The":[0],"mechanism":[1],"of":[2,4,12,43,60,63,75,77,87,114,121],"inhibition":[3,76],"insulin-based":[5],"amyloid":[6,37,115],"gel":[7],"formation":[8],"by":[9],"metal":[10],"derivatives":[11],"tetrakis(4-sulfonatophenyl)porphyrin":[13],"has":[14],"been":[15],"investigated.":[16],"Time-course":[17],"UV/vis":[18],"measurements":[19],"in":[20,99],"conjunction":[21],"with":[22,65],"atomic":[23],"force":[24],"microscopy":[25],"(AFM)":[26],"were":[27],"used":[28],"to":[29,84,89,106],"study":[30],"the":[31,61,73,78,85,96,100,104,112,118,122],"correlation":[32],"between":[33],"observed":[34],"kinetics":[35],"and":[36,103,117],"structure":[38,113],"for":[39],"various":[40,79],"concentration":[41],"ranges":[42],"added":[44],"metalloporphyrins.":[45],"Observed":[46],"structures":[47,55],"include":[48],"fibrils":[49],"as":[50,52,57],"well":[51],"circular,":[53],"ring-like":[54],"formed":[56,116],"a":[58],"result":[59],"interaction":[62],"insulin":[64],"porphyrin.":[66],"In":[67],"addition,":[68],"binding":[69,88],"studies":[70],"demonstrate":[71],"that":[72,94],"effectiveness":[74],"metalloporphyrins":[80],"is":[81,92],"directly":[82],"related":[83],"strength":[86],"insulin.":[90],"It":[91],"suggested":[93],"both":[95,111],"electron":[97],"distribution":[98],"porphyrin":[101,108],"core":[102],"tendency":[105],"form":[107],"dimers":[109],"affect":[110],"kinetic":[119],"profile":[120],"reaction.":[123]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
