{"id":"https://openalex.org/W2035213629","doi":"https://doi.org/10.1176/appi.pn.2015.2a26","title":"The Ketamine Challenge: When Practice Leaps Ahead of Science","display_name":"The Ketamine Challenge: When Practice Leaps Ahead of Science","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2035213629","doi":"https://doi.org/10.1176/appi.pn.2015.2a26","mag":"2035213629"},"language":"en","primary_location":{"id":"doi:10.1176/appi.pn.2015.2a26","doi":"https://doi.org/10.1176/appi.pn.2015.2a26","is_oa":false,"landing_page_url":"https://doi.org/10.1176/appi.pn.2015.2a26","pdf_url":null,"source":{"id":"https://openalex.org/S4210208841","display_name":"Psychiatric News","issn_l":"0033-2704","issn":["0033-2704","1559-1255"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800570","host_organization_name":"American Psychiatric Association Publishing","host_organization_lineage":["https://openalex.org/P4320800570","https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association Publishing","American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric News","raw_type":"journal-article"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey Lieberman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075093461"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"3","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.4490000009536743},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.9049999713897705},{"id":"https://openalex.org/keywords/phencyclidine","display_name":"phencyclidine","score":0.6710000038146973},{"id":"https://openalex.org/keywords/pcp","display_name":"PCP","score":0.7850000262260437},{"id":"https://openalex.org/keywords/glutamate-receptor-antagonists","display_name":"glutamate receptor antagonists","score":0.6690000295639038},{"id":"https://openalex.org/keywords/recreational-drug-use","display_name":"recreational drug use","score":0.5950000286102295},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.3709999918937683},{"id":"https://openalex.org/keywords/psychiatric-drug-development","display_name":"psychiatric drug development","score":0.30300000309944153},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.37299999594688416},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.5910000205039978},{"id":"https://openalex.org/keywords/ketamine-side-effects","display_name":"ketamine side effects","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.78246009349823},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5879572033882141},{"id":"https://openalex.org/C2777705401","wikidata":"https://www.wikidata.org/wiki/Q6457570","display_name":"LEAPS","level":2,"score":0.501431941986084},{"id":"https://openalex.org/C2778851735","wikidata":"https://www.wikidata.org/wiki/Q407324","display_name":"Phencyclidine","level":4,"score":0.4781421422958374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46371057629585266},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4338931441307068},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4073338806629181},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.1446698009967804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1176/appi.pn.2015.2a26","doi":"https://doi.org/10.1176/appi.pn.2015.2a26","is_oa":false,"landing_page_url":"https://doi.org/10.1176/appi.pn.2015.2a26","pdf_url":null,"source":{"id":"https://openalex.org/S4210208841","display_name":"Psychiatric News","issn_l":"0033-2704","issn":["0033-2704","1559-1255"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800570","host_organization_name":"American Psychiatric Association Publishing","host_organization_lineage":["https://openalex.org/P4320800570","https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association Publishing","American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric News","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402041934","https://openalex.org/W7215047767","https://openalex.org/W3010611789","https://openalex.org/W4221152597","https://openalex.org/W4240874715","https://openalex.org/W4390059368","https://openalex.org/W2095362576","https://openalex.org/W2488684598","https://openalex.org/W2474890852","https://openalex.org/W4399611354"],"abstract_inverted_index":{"Back":[0],"to":[1,52,103,150,156,180,258,389,399,415,425,463,496,504,521,529,573,595,608,644],"table":[2],"of":[3,15,58,108,130,173,272,302,370,378,475,488,637,663,672],"contents":[4],"Previous":[5],"article":[6],"ViewpointsFull":[7],"AccessThe":[8],"Ketamine":[9],"Challenge:":[10],"When":[11],"Practice":[12],"Leaps":[13],"Ahead":[14],"ScienceJeffrey":[16],"Lieberman,":[17,659],"M.D.Jeffrey":[18],"LiebermanSearch":[19],"for":[20,39,63,70,84,92,444,461,509,557,564],"more":[21,160],"papers":[22],"by":[23,168,239,436],"this":[24,408,531],"author,":[25],"M.D.Published":[26],"Online:3":[27],"Feb":[28],"2015https://doi.org/10.1176/appi.pn.2015.2a26AbstractWhen":[29],"is":[30,45,121,154,178,325,332,344,433,447,518,661],"a":[31,35,40,46,61,142,191,224,290,345,349,419,669],"promising":[32,47,506],"new":[33,409,507,585],"drug":[34,158,304,335],"medically":[36],"valid":[37],"treatment":[38,50,62,379],"diagnosed":[41],"disorder?":[42],"And":[43,118,525],"when":[44],"but":[48,289,599],"unproven":[49],"liable":[51],"be":[53,412,602,626],"used":[54,97,448],"prematurely?The":[55],"growing":[56],"popularity":[57],"ketamine":[59,136,283,360,478],"as":[60,112,141,151,163,223,422,588,590,633],"mental":[64,109,631],"disorders":[65,110],"poses":[66],"an":[67,77],"interesting":[68],"challenge":[69],"clinicians,":[71],"patients,":[72,467],"and":[73,91,114,133,183,199,208,212,247,282,314,339,355,391,395,430,454,491,500,541,545,570,623,625,628,647,668],"policymakers.":[74],"The":[75,458],"drug,":[76],"anesthetic":[78],"that":[79,147,280,296,315,372,581],"has":[80,95,137,278],"traditionally":[81],"been":[82,96,515],"prescribed":[83],"pediatric":[85],"patients":[86,230,387,417],"undergoing":[87],"minor":[88],"surgical":[89],"procedures":[90],"burn":[93],"victims,":[94],"over":[98,566],"the":[99,123,126,157,170,174,187,196,202,210,236,253,297,300,303,334,368,393,403,442,473,485,534,552,560,567,574,621],"last":[100,568],"few":[101],"years":[102],"treat":[104],"severe,":[105,211],"difficult-to-treat":[106],"cases":[107],"such":[111],"depression":[113,371],"obsessive-compulsive":[115],"disorder":[116],"(OCD).":[117],"its":[119,131,206,428,431],"use":[120,400,505],"on":[122,262],"rise.":[124],"At":[125],"same":[127,553],"time,":[128],"because":[129],"mind-bending":[132],"euphoriant":[134],"effects,":[135],"also":[138],"found":[139],"favor":[140],"recreational":[143,193,266],"or":[144,241,322,523,533],"\u201cclub":[145],"drug\u201d":[146],"some":[148],"refer":[149],"\u201cSpecial":[152],"K.\u201dKetamine":[153],"related":[155],"phencyclidine,":[159],"commonly":[161],"known":[162],"PCP.":[164],"Both":[165],"medications":[166,256],"act":[167],"blocking":[169],"excitatory":[171],"effects":[172,313,324,354],"neurotransmitter":[175],"glutamate,":[176],"which":[177,306,317,445],"integral":[179],"information":[181],"processing":[182],"memory":[184],"formation":[185],"in":[186,195,299,366,418,438,466,559,578,615,634],"brain.":[188],"PCP":[189,233,281],"was":[190],"popular":[192],"hallucinogen":[194],"late":[197,561],"1970s":[198],"1980s":[200],"before":[201,512],"medical":[203],"community":[204],"recognized":[205],"toxicity":[207],"understood":[209],"sometimes":[213],"psychotic,":[214],"reactions":[215],"it":[216,307,318,446],"caused.I":[217],"vividly":[218],"remember":[219],"my":[220],"own":[221],"experience":[222],"psychiatric":[225],"resident":[226],"seeing":[227],"desperate,":[228],"maniacal":[229],"intoxicated":[231],"with":[232,359,477,555],"brought":[234],"into":[235,593],"emergency":[237],"room":[238],"police":[240],"ambulance.":[242],"Many":[243],"were":[244,265,397],"wildly":[245],"agitated":[246],"completely":[248,613],"detached":[249],"from":[250,539],"reality.":[251],"Even":[252],"most":[254,648],"potent":[255],"seemed":[257],"have":[259,285,514],"no":[260,656],"effect":[261],"them.":[263],"Most":[264],"users":[267],"who,":[268],"through":[269],"their":[270],"abuse":[271],"PCP,":[273],"had":[274,373],"developed":[275],"psychotic":[276],"behaviors.Research":[277],"shown":[279],"do":[284,655],"genuine":[286],"therapeutic":[287,292,310,364,410],"uses":[288],"narrow":[291],"index.":[293],"This":[294],"means":[295],"difference":[298],"dosage":[301],"at":[305,316,665],"will":[308,319],"produce":[309],"(beneficial":[311],"medical)":[312],"cause":[320,337],"adverse":[321],"toxic":[323,356],"very":[326],"small.":[327],"So":[328],"if":[329],"too":[330,606],"much":[331,499],"taken,":[333],"can":[336,407,592],"adverse,":[338],"potentially":[340],"disastrous,":[341],"consequences.":[342],"There":[343],"fine":[346],"line":[347],"between":[348],"medicinal":[350],"substance":[351],"producing":[352],"salutary":[353],"effects.When":[357],"research":[358,476,586],"first":[361],"showed":[362],"dramatic":[363],"potential":[365,429],"alleviating":[367],"symptoms":[369],"resisted":[374],"all":[375],"approved":[376],"forms":[377],"(psychotherapy,":[380],"antidepressant":[381],"medications,":[382],"even":[383],"electroshock":[384],"therapy),":[385],"desperate":[386],"began":[388],"seek":[390],"demand":[392],"treatment,":[394],"clinicians":[396],"eager":[398],"it.":[401],"But":[402],"question":[404],"is,":[405],"how":[406,498,501],"option":[411],"best":[413],"applied":[414],"serve":[416],"beneficial":[420],"way":[421],"we":[423,481,582,591,600,611,640],"continue":[424],"learn":[426],"about":[427,604],"consequences?Ketamine":[432],"usually":[434],"given":[435],"injection":[437],"single":[439],"doses.":[440],"Yet":[441],"conditions":[443],"(depression,":[449],"OCD,":[450],"etc.)":[451],"require":[452],"ongoing":[453],"often":[455,542],"lifelong":[456],"therapy.":[457],"dosing":[459],"intervals":[460],"ketamine,":[462],"maintain":[464],"improvement":[465],"are":[468,487,537],"not":[469,519,527],"yet":[470],"understood.":[471],"Although":[472],"results":[474],"appear":[479],"promising,":[480],"must":[482,583,601,619,641],"determine":[483],"what":[484],"consequences":[486],"repeated":[489],"administrations":[490],"long-term":[492],"use.":[493],"We":[494,550,618],"need":[495],"know":[497],"often.The":[502],"pressure":[503,532,624],"treatments":[508,556,563,594],"clinical":[510,616],"purposes":[511],"they":[513,546],"fully":[516],"tested":[517],"unique":[520],"psychiatry":[522,664],"ketamine.":[524],"it\u2019s":[526],"hard":[528],"understand":[530,614],"urgency.":[535],"People":[536],"suffering":[538],"disabling":[540],"life-threatening":[543],"conditions,":[544],"want\u2014and":[547],"deserve\u2014appropriate":[548],"treatment.":[549],"experienced":[551],"phenomenon":[554],"HIV/AIDS":[558],"1980s,":[562],"cancer":[565],"half-century,":[569],"recent":[571],"responses":[572],"devastating":[575],"Ebola":[576],"outbreak":[577],"Africa.I":[579],"believe":[580],"translate":[584],"findings":[587],"rapidly":[589],"improve":[596],"patients\u2019":[597],"lives,":[598],"cautious":[603],"moving":[605],"quickly":[607],"apply":[609],"therapies":[610],"don\u2019t":[612],"practice.":[617],"resist":[620],"temptation":[622],"deliberate":[627],"careful.":[629],"In":[630],"illness,":[632],"every":[635],"form":[636],"human":[638],"disease,":[639],"stay":[642],"true":[643],"our":[645],"oldest":[646],"essential":[649],"principle:":[650],"primum":[651],"non":[652],"nocere.":[653],"First,":[654],"harm.":[657],"\u25a0Jeffrey":[658],"M.D.,":[660],"chair":[662],"Columbia":[666],"University":[667],"past":[670],"president":[671],"APA.":[673],"ISSUES":[674],"NewArchived":[675]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
