{"id":"https://openalex.org/W2034980488","doi":"https://doi.org/10.1158/1940-6207.prev-10-a49","title":"Abstract A49: Verification of two novel phytochemical inducers of phase II metabolic enzyme NQO1 in human lung cells","display_name":"Abstract A49: Verification of two novel phytochemical inducers of phase II metabolic enzyme NQO1 in human lung cells","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2034980488","doi":"https://doi.org/10.1158/1940-6207.prev-10-a49","mag":"2034980488"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.prev-10-a49","doi":"https://doi.org/10.1158/1940-6207.prev-10-a49","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-10-a49","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074527277","display_name":"Gaby Marquardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaby Marquardt","raw_affiliation_strings":["1Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100856608","display_name":"Xiang\u2010Lin Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianglin Tan","raw_affiliation_strings":["1Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087733435","display_name":"Simon D. Spivack","orcid":"https://orcid.org/0000-0002-8338-8906","observed_orcids":["https://orcid.org/0000-0002-8338-8906"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon D. Spivack","raw_affiliation_strings":["1Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"12_Supplement","first_page":"A49","last_page":"A49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nqo1-induction","display_name":"NQO1 induction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lung-cancer-chemoprevention","display_name":"lung cancer chemoprevention","score":0.8980000019073486},{"id":"https://openalex.org/keywords/human-bronchial-epithelial-cells","display_name":"human bronchial epithelial cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.777999997138977},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9980000257492065},{"id":"https://openalex.org/keywords/natural-product-screening","display_name":"natural product screening","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2780841255","wikidata":"https://www.wikidata.org/wiki/Q424489","display_name":"Sulforaphane","level":2,"score":0.818638265132904},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6570071578025818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5579568147659302},{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.4397680163383484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4360809326171875},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43458759784698486},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4315287470817566},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4226733446121216},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.42135557532310486},{"id":"https://openalex.org/C155701950","wikidata":"https://www.wikidata.org/wiki/Q14905165","display_name":"CYP1B1","level":4,"score":0.41428178548812866},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3933256268501282},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13591212034225464},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.11076933145523071}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.prev-10-a49","doi":"https://doi.org/10.1158/1940-6207.prev-10-a49","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-10-a49","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2314792707","https://openalex.org/W2086734293","https://openalex.org/W2000793531","https://openalex.org/W2171905533","https://openalex.org/W2064031744","https://openalex.org/W2118587710","https://openalex.org/W3203378594","https://openalex.org/W2051958922","https://openalex.org/W1982804638","https://openalex.org/W2103207990"],"abstract_inverted_index":{"Abstract":[0],"One":[1],"strategy":[2],"for":[3,126,176,240,331,338,371],"lung":[4,45,298],"cancer":[5],"chemoprevention":[6],"focuses":[7],"on":[8,76,281,349],"the":[9,15,67,78,131,275,350,353,363,374,380],"use":[10],"of":[11,19,27,151,164,191,195,207,246,250,262,274,307,352],"agents":[12,39,167,345],"to":[13,35,57,73,136,148,197,209,221,228,252,264,297,391],"modulate":[14],"metabolism":[16],"and":[17,22,62,86,99,116,141,153,173,181,204,226,259,293,317,359,367,388],"disposition":[18],"tobacco,":[20],"environmental":[21],"endogenous":[23],"carcinogens":[24],"through":[25],"up-regulation":[26,190,206,245,261,351],"detoxifying":[28,354],"phase":[29,79],"II":[30,80],"enzymes.":[31],"However,":[32],"in":[33,43,66,91,134,144,200,212,224,231,255,267,284,312],"studies":[34],"date,":[36],"most":[37,381],"candidate":[38,383],"are":[40],"not":[41],"active":[42],"human":[44,94,101],"cells.":[46,215,234,286],"Therefore":[47],"we":[48],"previously":[49],"applied":[50],"a":[51,162,289,327],"gene":[52],"expression-based":[53],"high-throughput":[54],"screening":[55],"approach":[56],"investigate":[58],"n=800":[59],"plant-derived":[60,393],"polyphenolic-":[61],"flavenoid-":[63],"predominant":[64],"compounds":[65,277],"MicroSource":[68],"Natural":[69],"Products":[70],"Library":[71],"as":[72,123,159,161],"their":[74],"effect":[75,280,330,335,348,364],"inducing":[77],"metabolic":[81],"enzymes":[82],"glutathione":[83],"S-transferases":[84],"(GSTP1)":[85],"NAD(P)H:quinone":[87],"oxidoreductase":[88],"1":[89],"(NQO1)":[90],"primary":[92],"normal":[93],"bronchial":[95,102],"epithelial":[96,103],"(NHBE)":[97],"cells":[98,104,143,203,236,258,270,299],"immortalized":[100],"(HBEC).":[105],"We":[106,303],"had":[107,278,288],"identified":[108],"2,":[109],"3-dihydroxy-4-methoxy-4\u2019-ethoxybenzophenone":[110],"(DMEBP,":[111],"putative":[112,119],"source":[113,120],"arctic":[114],"sponge)":[115],"triacetylresveratrol":[117],"(TRES,":[118],"plant":[121],"myrtle)":[122],"new":[124,344],"inducers":[125],"NQO1":[127,192,216,247,356],"mRNA":[128,193,241,248,358],"expression.":[129],"In":[130],"current":[132],"study,":[133],"order":[135],"confirm":[137],"our":[138],"results,":[139],"NHBE":[140,202,214,233,313],"HBEC":[142,235,257,269,285],"culture":[145],"were":[146],"exposed":[147],"diet-achievable":[149],"levels":[150],"TRES":[152,378],"DMEBP":[154,287],"(0.5,":[155],"1.0,":[156],"2.0":[157],"\u00b5M),":[158],"well":[160],"panel":[163],"conventionally-recognized":[165],"phytopreventive":[166],"[epigallocatechin":[168],"gallate":[169],"(EGCG),":[170],"resveratrol":[171],"(RES)":[172],"sulforaphane":[174],"(SFN)]":[175],"24":[177],"h,":[178,180],"48":[179],"6":[182],"d,":[183],"respectively.":[184],"Quantitative":[185],"RNA-specific":[186],"RT-PCR":[187],"showed":[188,237],"an":[189,205,244,260,279],"expression":[194,218,242,249,283],"up":[196,208,220,227,251,263],"10.8":[198],"fold":[199,211,223,230,254,266],"DMEBP-treated":[201,225,256],"4.6":[210],"TRES-treated":[213,232,268],"protein":[217,282,360],"increased":[219],"3.4":[222],"1.8":[229],"similar":[238],"results":[239],"\u2014":[243,271],"9.7":[253],"3.1":[265],"whereas":[272],"none":[273,368],"tested":[276],"narrow":[290],"therapeutic":[291],"window,":[292],"was":[294,365,369],"notably":[295],"toxic":[296],"at":[300,357],"1-2":[301],"\u00b5M.":[302],"then":[304],"measured":[305],"accumulation":[306],"reactive":[308],"oxygen":[309],"species":[310],"(ROS)":[311],"cell":[314],"using":[315],"DFA,":[316],"total":[318],"GSH":[319],"assays.":[320],"Our":[321,340],"ROS":[322],"data":[323,341],"so":[324],"far":[325],"show":[326,342],"slight":[328],"anti-oxidant":[329],"DMEBP,":[332],"but":[333,362],"no":[334],"yet":[336],"found":[337],"TRES.":[339],"two":[343],"have":[346],"some":[347],"enzyme":[355],"levels,":[361],"modest,":[366],"observed":[370],"GSTP1.":[372],"Among":[373],"newly":[375],"discovered":[376],"agents,":[377],"is":[379],"plausible":[382],"resulting":[384],"from":[385],"this":[386],"search,":[387],"compares":[389],"favorably,":[390],"conventional":[392],"polyphenolics/flavenoids":[394],"tested.":[395],"Citation":[396],"Information:":[397],"Cancer":[398],"Prev":[399],"Res":[400],"2010;3(12":[401],"Suppl):A49.":[402]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
