{"id":"https://openalex.org/W2034896261","doi":"https://doi.org/10.1097/01.qai.0000351081.04956.24","title":"124 NK cells: friends or foes?","display_name":"124 NK cells: friends or foes?","publication_year":2009,"publication_date":"2009-05-25","ids":{"openalex":"https://openalex.org/W2034896261","doi":"https://doi.org/10.1097/01.qai.0000351081.04956.24","mag":"2034896261"},"language":"en","primary_location":{"id":"doi:10.1097/01.qai.0000351081.04956.24","doi":"https://doi.org/10.1097/01.qai.0000351081.04956.24","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000351081.04956.24","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059371880","display_name":"Galit Alter","orcid":"https://orcid.org/0000-0002-7680-9215","observed_orcids":["https://orcid.org/0000-0002-7680-9215","https://orcid.org/0000-0002-9221-6735","https://orcid.org/0000-0003-1570-9445"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galit Alter","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109351623","display_name":"Daniel G. Kavanagh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kavanagh","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082442388","display_name":"Suzannah J. Rihn","orcid":"https://orcid.org/0000-0001-9495-4056","observed_orcids":["https://orcid.org/0000-0001-9495-4056"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzannah Rihn","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007653095","display_name":"Maureen P. Martin","orcid":"https://orcid.org/0000-0002-0990-3500","observed_orcids":["https://orcid.org/0000-0002-0990-3500"]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen Martin","raw_affiliation_strings":["Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, Frederick, MD","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015541994","display_name":"Mary N Carrington","orcid":"https://orcid.org/0000-0002-2692-2180","observed_orcids":["https://orcid.org/0000-0002-2692-2180"]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Carrington","raw_affiliation_strings":["Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, Frederick, MD","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042817775","display_name":"Marcus A. Altfeld","orcid":"https://orcid.org/0000-0001-5972-2997","observed_orcids":["https://orcid.org/0000-0001-5972-2997"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Altfeld","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1738741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"Supplement 2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/acute-hiv-1-infection","display_name":"acute HIV-1 infection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/kir3ds1","display_name":"KIR3DS1","score":0.847000002861023},{"id":"https://openalex.org/keywords/hla-bw4","display_name":"HLA-Bw4","score":0.8500000238418579},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6549999713897705},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8579999804496765},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7978841066360474},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7194937467575073},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.6720490455627441},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6304780840873718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5802247524261475},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5740503668785095},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4970431625843048},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.47620996832847595},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.47277405858039856},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4273199439048767},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38517454266548157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2366567850112915},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18866252899169922},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1292697787284851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08204391598701477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08056363463401794}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.qai.0000351081.04956.24","doi":"https://doi.org/10.1097/01.qai.0000351081.04956.24","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000351081.04956.24","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2128306333","https://openalex.org/W2300525012","https://openalex.org/W1997851714","https://openalex.org/W2067165659","https://openalex.org/W1965805920","https://openalex.org/W2058321555","https://openalex.org/W1979465331","https://openalex.org/W1971768704","https://openalex.org/W2579450476","https://openalex.org/W2133372274"],"abstract_inverted_index":{"Decline":[0],"of":[1,13,20,26,53,74,108,124,158],"peak":[2],"viremia":[3],"during":[4,114],"acute":[5,115],"HIV-1":[6],"infection":[7,116],"occurs":[8],"prior":[9],"to":[10,93,120],"the":[11,18,34,50,75,125,156],"development":[12],"vigorous":[14,66],"adaptive":[15,68,126],"immunity":[16],"and":[17,81,112],"level":[19],"decline":[21],"correlates":[22],"inversely":[23],"with":[24,90,101],"rate":[25],"AIDS":[27],"progression,":[28],"implicating":[29],"a":[30,60,65,141],"potential":[31],"role":[32,62,142],"for":[33],"innate":[35],"immune":[36,69,127],"response":[37],"in":[38,49,63,122,143,155,162],"determining":[39],"disease":[40,153],"outcome.":[41],"Natural":[42],"Killer":[43],"(NK)":[44],"cells":[45,139],"are":[46],"critical":[47,61],"both":[48,144],"early":[51],"control":[52],"various":[54],"viral":[55],"infections":[56],"but":[57],"also":[58],"play":[59,140],"inducing":[64],"antiviral":[67],"response.":[70,128],"The":[71],"combined":[72],"expression":[73],"activating":[76],"NK":[77,109,138],"cell":[78,110],"receptor":[79],"KIR3DS1":[80],"its":[82],"presumed":[83],"ligand":[84],"HLA-B":[85],"Bw4-80I":[86],"has":[87],"been":[88],"associated":[89],"slow":[91],"progression":[92,154],"AIDS,":[94],"however":[95],"it":[96],"is":[97],"uncertain":[98],"whether":[99],"subjects":[100],"this":[102],"genotype":[103],"exhibit":[104],"qualitatively":[105],"different":[106],"patterns":[107],"expansions":[111],"contractions":[113],"that":[117,137],"may":[118],"contribute":[119],"differences":[121],"patterning":[123],"This":[129],"presentation":[130],"will":[131],"highlight":[132],"our":[133],"recent":[134],"findings":[135],"demonstrating":[136],"promoting":[145],"pathogenic":[146],"events":[147],"as":[148,150],"well":[149],"protecting":[151],"against":[152],"presence":[157],"protective":[159],"KIR/HLA":[160],"genotypes":[161],"HIV":[163],"infection.":[164]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
