{"id":"https://openalex.org/W2034737494","doi":"https://doi.org/10.3923/pjbs.2007.4246.4250","title":"Frequent Homozygous Deletion of p16/CDKN2A Gene in Malignant Gliomas of Iranian Patients","display_name":"Frequent Homozygous Deletion of p16/CDKN2A Gene in Malignant Gliomas of Iranian Patients","publication_year":2007,"publication_date":"2007-11-15","ids":{"openalex":"https://openalex.org/W2034737494","doi":"https://doi.org/10.3923/pjbs.2007.4246.4250","mag":"2034737494","pmid":"https://pubmed.ncbi.nlm.nih.gov/19086579"},"language":"en","primary_location":{"id":"doi:10.3923/pjbs.2007.4246.4250","doi":"https://doi.org/10.3923/pjbs.2007.4246.4250","is_oa":false,"landing_page_url":"https://doi.org/10.3923/pjbs.2007.4246.4250","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mohammad Dilmaghani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Dilmaghani","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box 14155-5983, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box 14155-5983, Tehran, Iran","institution_ids":["https://openalex.org/I161106909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108644821","display_name":"Reza Amini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reza Amini .","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068751020","display_name":"Mohsen Firoozrai","orcid":"https://orcid.org/0000-0001-6544-5519","observed_orcids":["https://orcid.org/0000-0001-6544-5519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohsen Firoozray .","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Pupak Derakhshandeh- .","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pupak Derakhshandeh- .","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"23","first_page":"4246","last_page":"4250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9620000123977661},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/exon-2-deletion","display_name":"exon 2 deletion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/iranian-patients","display_name":"Iranian patients","score":0.6060000061988831},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.9409846067428589},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8343813419342041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5925691723823547},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.5853231549263},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.502530574798584},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.49982166290283203},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4873571991920471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41056564450263977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4032214283943176},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3231278955936432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2495429515838623}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3923/pjbs.2007.4246.4250","doi":"https://doi.org/10.3923/pjbs.2007.4246.4250","is_oa":false,"landing_page_url":"https://doi.org/10.3923/pjbs.2007.4246.4250","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:19086579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19086579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of biological sciences : PJBS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2413132787"],"related_works":["https://openalex.org/W4379334224","https://openalex.org/W1560647015","https://openalex.org/W2038174146","https://openalex.org/W1497143324","https://openalex.org/W1972122268","https://openalex.org/W6921338034","https://openalex.org/W2057110340","https://openalex.org/W1514125758","https://openalex.org/W4392606884","https://openalex.org/W2074730382"],"abstract_inverted_index":{"Homozygous":[0],"deletion":[1,27,69],"is":[2],"the":[3,25,35],"main":[4],"mechanism":[5],"of":[6,37,73,77,83,87,94,98],"CDKN2A":[7,38,105,111],"gene":[8,39],"inactivation":[9],"in":[10,40,70,90],"malignant":[11,42,99],"gliomas.":[12,100],"However":[13],"different":[14],"frequencies":[15],"were":[16,108],"reported":[17],"for":[18],"its":[19],"deletion.":[20],"In":[21],"order":[22],"to":[23],"find":[24],"homozygous":[26,68],"frequency":[28],"among":[29],"Iranian":[30],"patients,":[31],"we":[32],"have":[33],"analyzed":[34],"status":[36],"40":[41,95],"gliomas":[43],"and":[44,48,80,114],"examined":[45],"their":[46],"lalpha":[47],"2":[49,117],"exons":[50],"by":[51],"comparative":[52],"multiplex":[53],"Polymerase":[54],"Chain":[55],"Reaction":[56],"(PCR),":[57],"using":[58],"D9S171":[59],"chromosomal":[60],"marker":[61],"as":[62],"an":[63],"internal":[64],"control.":[65],"We":[66,101],"found":[67,103],"6":[71],"out":[72,82,93],"7":[74],"cases":[75,85,96],"(85.7%)":[76],"anaplastic":[78],"astrocytomas":[79],"20":[81],"33":[84],"(60.6%)":[86],"glioblastoma":[88],"multiforme,":[89],"total":[91],"26":[92],"(65%)":[97],"also":[102],"that":[104,115],"deleted":[106,119],"patients":[107,113],"younger":[109],"than":[110,121],"non-deleted":[112],"exon":[116,122],"was":[118],"more":[120],"1alpha.":[123]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
